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Öğe CRUCIAL MARKERS SHOWING THE RISK OF CORONARY ARTERY DISEASE IN OBESITY: ADMA AND NEOPTERIN(Soc Medical Biochemists Serbia, 2020) Avci, Emre; Karabulut, Alpaslan; Avci, Avci Alp; Baba, Burcu; Bilgi, CumhurBackground: Obesity is responsible for high morbidity and mortality, both in developed and developing countries. It is associated with many chronic and metabolic diseases. Asymmetric dimethylarginine (ADMA) has been demonstrated to be a biomarker of endothelial dysfunction in humans and increased ADMA associated with cardiovascular disease (CVD) risk has been reported in many states. Neopterin (NP) produced by monocytes/macrophages in response to stimulation by interferon-gamma (IFN-gamma) is emphasized in recent findings. The current study aims to investigate ADMA and NP levels which may assume a role in guiding the early diagnosis of coronary artery disease in obesity. Methods: This is an original research study in which ADMA and NP levels of 50 patients (25 male/25 female) diagnosed with obesity were compared with those of 30 healthy individuals (15 male/15 female) as control. The high-performance liquid chromatography (HPLC) method was used while determining parameters. Results: ADMA and NP levels in obese individuals were found to be significantly higher than in those enrolled in the control. ADMA values were found to be higher in obese subjects (0.71 +/- 0.24 mu mol/L) as compared with levels found in healthy subjects (0.58 +/- 0.16 mu mol/L) (p<0.05). A significant increase of serum neopterin levels was found in obese subjects (8.8 +/- 3.5 mu mol/L) as compared with controls (4.9 +/- 1.69 mu mol/L) (p<0.05). Also, there was a strong positive correlation between NP and ADMA values in obese individuals (r=0.954). Conclusions: Our study revealed that obese subjects have higher ADMA and neopterin levels. These results demonstrated that both ADMA and NP levels may be potential risk factors for coronary heart disease in obesity.Öğe Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure(Informa Healthcare, 2014) Avcı, Emre; Çakır, Erdinç; Coşkun Cevher, Şule; Yaman, Halil; Ağıllı, Mehmet; Bilgi, CumhurObjectives: We aimed to evaluate oxidative stress [8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA)] endothelial damage [asymmetric dimethylarginine (ADMA)] and markers of cellular inflammation [interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-?), neopterin (NP) and high-sensitivity C-reactive protein (hsCRP)] in patients with diabetic nephropathy (DN) and non-diabetic nephropathy who were being administered hemodialysis treatment because of chronic renal failure. Methods: In determining 8-OHdG, IL-6 and TNF-? levels, Enzyme-Linked Immuno-Sorbent Assay method was used. Serum MDA, ADMA and NP levels were determined by using high performance liquid chromatography (HPLC). And hs-CRP values were measured with nephelometric method. Results: Serum 8-OHdG and MDA levels were found statistically to have increased when compared with those of the control group in patients groups after dialysis. However, serum ADMA and neopterin levels were observed statistically to have decreased when compared with those of the control group in patients groups after dialysis. But, decreases on ADMA and neopterin levels are still much higher than those of control. IL-6 and TNF-? levels were found to have increased when compared with those of control group in patients groups before dialysis. Conclusion: The oxidative stress in patients with DN, who were being treated with hemodialysis due to chronic renal failure, was higher than that of non-DN patients who were being treated with hemodialysis. In contrast with this, inflammation occurring in non-DN patients was found to have been higher than that of in patients with DN.Öğe Evaluation of cytokines concentrations and oxidative DNA damage in patients with diabetic nephropathy and non- diabetic nephropathy undergoing hemodialysis(Wiley-Blackwell, 2012) Avcı, Emre; Coşkun Cevher, Şule; Çakır, Erdinç; Yaman, Halil; Ağıllı, Mehmet; Bali, Musa; Bilgi, Cumhur[Abstract Not Available]Öğe Malondialdehyde, an indicator of lipid peroxidation, concentrations in patients with diabetic nephropathy and non-diabetic nephropathy undergoing hemodialysis(Wiley-Blackwell, 2011) Avcı, Emre; Coşkun Cevher, Şule; Çakır, Erdinç; Yaman, Halil; Bilgi, Cumhur[Abstract Not Available]
