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    Assessment of the Relationship Between C-Reactive Protein to Albumin Ratio and New-Onset Atrial Fibrillation in Patients with ST Elevation Myocardial Infarction
    (2019) Yesin, Mahmut; Çağdaş, Metin; Karabağ, Yavuz; Rencüzoğulları, İbrahim; Kalçık, Macit; Burak, Cengiz; Tanboğa, İbrahim Halil
    Introduction: Previous studies reported that inflammatory markers are associated with the development of new-onset atrial fibrillation (NOAF) in patients with coronary artery disease. However, the predictive value of serum C-reactive protein (CRP) to serum albumin ratio (CAR) for the development of NOAF in patients with ST elevation myocardial infarction (STEMI) has not been investigated yet. Hence, the aim of the present study was to evaluate the potential utility of the CAR in predicting NOAF in patients with STEMI who underwent primary percutaneous coronary intervention (pPCI). Patients and Methods: The present study was a retrospective analysis of the data related to 1153 patients with STEMI who underwent pPCI. CRP levels were measured according to the immunoturbidimetric method, and serum albumin levels were analyzed by the bromocresol green method. The CAR was defined as the serum CRP level divided by the serum albumin level. Results: The incidence of NOAF during in-hospital stay was 5.2% (n= 62 patients). Patients with NOAF had higher CAR values than those without NOAF. Multivariate logistic regression analyses revealed that elevated CAR value was an independent predictor of NOAF (odds ratio 3.280, 95% confidence interval 1.564-6.878; p= 0.002). Furthermore, comparison of receiver operating characteristic curves yielded that the predictive performance of CAR was higher than CRP and albumin alone, respectively. Conclusion: In the present study, we observed that elevated CAR values were independently associated with NOAF development in patients with STEMI treated with pPCI.
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    Öğe
    Assessment of the relationship between C-reactive protein-to-albumin ratio and slow coronary flow in patients with stable angina pectoris
    (Lippincott Williams & Wilkins, 2019) Yesin, Mahmut; Çağdaş, Metin; Karabağ, Yavuz; Rencuzoğulları, İbrahim; Burak, Cengiz; Kalçık, Macit; Karakoyun, Süleyman
    Background The relationship between severity of coronary artery disease and inflammatory parameters has been previously demonstrated. However, there is a lack of data regarding the role of C-reactive protein-to-albumin ratio (CAR) in slow coronary flow (SCF) in patients with stable angina pectoris (SAP). In this study, we aimed to investigate the relationship between CAR and presence of SCF in patients with SAP. Patients and methods This study enrolled 217 patients undergoing coronary angiography for SAP. SCF was detected in 81 (37.3%) patients, and the control group included 136 patients. All clinical, demographical, and laboratory parameters were entered into a dataset and compared between SCF group and the controls. Results The mean age of the patients was 66.1 +/- 12.1 years (male: 57.1%). C-reactive protein and CAR were significantly higher in patients with SCF compared with controls (P = 0.004 and < 0.001, respectively). Logistic regression analysis demonstrated that high CAR level was an independent determinant of SCF (odds ratio: 1.023; 95% confidence interval: 1.013-1.034; P < 0.001). Conclusion Higher CAR level may be a valuable predictor of SCF in patients with SAP who undergo coronary angiography. Inflammation may play an important role in the pathogenesis of SCF.