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Öğe Is thyroid function associated with masked hypertension?(Turkish Society of Cardiology, 2016) Ateş, İhsan; Altay, Mustafa; Kaplan, Mustafa; Arıkan, Mehmet Fettah; Özkayar, Nihal; Alagüney, Mehmet Erdem; Dede, Fatih; Özkara, AdemMasked hypertension (MHT) was first defined by Pickering in 1992, and its importance is progressively increasing (1). MHT is a condition wherein blood pressure measured according to hypertension guidelines in office is normal, whereas the mean 24-h ambulatory blood pressure measurement or blood pressure measurement out of office is high (2). Studies relating to the etiology of MHT is limited, and possible etiological factors include work stress, smoking, alcohol use, male sex, and excessive physical activity (3, 4). The association between MHT and thyroid hormone, which has major effects on the cardiovascular system, is not known. This study aims to investigate the association between thyroid hormone and blood pressure in newly diagnosed MHT patientsÖğe Subclinical Cardiovascular Risk Factors in Chronic Kidney Disease: Abnormal Heart Rate Recovery(2020) Turgut, Didem; Yenigün, Ezgi Coşkun; Kundi, Harun; Özyakar, Nihal; Dede, FatihObjective: Chronic kidney disease (CKD) is associated with increased mortality and high cardiovascular (CV) risk. Slow heart rate recovery (HRR) is an index of cardiac autonomic dysfunction and also a prognostic tool for cardiac and all-cause mortality in high-risk groups. In this study, we aimed to investigate the subclinical CV risk factor in different stages of CKD. Materials and Methods: Fifty-one patients with stage 1–5 CKD (mean age, 42.5±8.1 years) and 42 healthy individuals (mean age, 36.0±7.9 years) were included in the study. The HRR was calculated by subtracting the heart rates in the 1st, 2nd, and 3rd minute of the recovery period from the maximum heart rate attained during the exercise stress test. Results: The HRR in the 1st minute was significantly slower in the CKD group compared with that in the control group (22.4±11.3 and 32.4±11.1, respectively; p<0.001). The HRR in the 2nd and 3rd minute was also slower in the patient group, but the difference was not statistically significant. Seventeen patients with the 1st minute HRR ?18 beats/min were mainly distributed in CKD stages 4 and 5. Conclusion: Patients with CKD with no known cardiac disease and no structural cardiac changes were at risk of CV events with a slow HRR in the exercise test. Clinicians should be careful not to underestimate CV events in this group of patients.Öğe The association between hope, anxiety, depression, coping strategies and perceived social support in patients with chronic kidney disease(Yerkure Tanitim ve Yayincilik Hizmetleri A.S., 2019) Yücens, Bengü; Kotan, Vahap Ozan; Özkayar, Nihal; Kotan, Zeynep; Yüksel, Rabia Nazik; Bayram, Şenol; Dede, Fatih; Göka, ErolObjective: Patients with chronic kidney disease (CKD) may experience psychiatric problems while having to cope with the various characteristics of the disease. Identifying the level of hope, coping strategies, and perceived social support may provide valuable information to improve treatment plans and the response to treatment. This study aimed to evaluate the association between hope, anxiety, depression, coping strategies, and perceived social support in patients with CKD. Method: A total of 65 grade 3 or 4 CKD patients and a healthy control group (51 volunteers) with matched baseline sociodemographic characteristics were included. The participants were evaluated using a sociodemographic data form, the Herth Hope Scale (HHS), Hospital Anxiety Depression Scale (HADS), COPE Inventory, and the Multidimensional Scale of Perceived Social Support (MSPSS). Results: The level of hope was lower, depression scores were higher and non-functional coping strategies were observed more often in patients with CKD compared to the healthy control group. In multiple linear regression analysis, anxiety and depression levels were found to have a negative effect and perceived social support by the family a positive effect on the level of hope in patients with CKD. Conclusion: Anxiety, depression, and perceived social support by the family predict the hope level of patients with CKD. A multidisciplinary approach including psychiatric consultation should be adopted in the treatment of patients with CKD as hope plays an important role in treatment compliance. © 2019 Yerkure Tanitim ve Yayincilik Hizmetleri A.S. All Rights Reserved.Öğe THE RELATIONSHIP BETWEEN PHYSICAL ACTIVITY STATUS AND SERUM IRISIN AND MYOSTATIN LEVELS IN PATIENTS WITH NON-DIALYSIS CHRONIC KIDNEY DISEASE(Oxford Univ Press, 2017) Bayrakci, Nergiz; Tasoglu, Ozlem; Ozkayar, Nihal; Ada, Bilge; Turhan, Turan; Ates, Ihsan; Dede, Fatih[Abstract Not Available]Öğe Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems(Tubitak Scientific & Technical Research Council Turkey, 2020) Turgut, Didem; Piskinpasa, Serhan Vahit; Yenigun, Ezgi Coskun; Aydemir, Nihal; Dede, FatihBackground/aim: Neutrophil gelatinase-associated lipocalin (NGAL) is used previously to estimate the etiology, severity, and clinical outcomes of acute kidney injury (AKI). However, the role of urinary NGAL (uNGAL) in the postrenal setting is not clear. In our study, we aimed to discover the cut-off value of uNGAL that can be used in the differential diagnosis of underlying AKI etiologies. Materials and methods: In this prospective cross-sectional study, we examined 82 subjects in four groups: patients that had (1) postrenal AKI; (2) AKI other than postrenal etiologies; (3) stable chronic kidney disease; and (4) healthy subjects. A renal function assessment was carried out by measuring serum creatininc (sCr) and uNGAL at the time of diagnosis [0th min (T0)]. We followed the study group for three months. Results: At the time of diagnosis, sCr (T0) was highest in the postrenal AKI and AKI groups in contrast to stable chronic kidney disease patients and healthy subjects (P < 0.001), as expected. T0 median uNGAL was highest in the postrenal group (P < 0.001). Area under curve (AUC) of uNGAL to estimate postrenal AKI presence was 0.957 (95% CI, 0.897-1.000; P < 0.001). The cut-off point of uNGAL was 42.625 ng/mL for this estimation. Conclusion: Patients with AKI must be classified according to the underlying etiologies as soon as possible. uNGAL may be useful to estimate the etiologies, and whether the problem is acute or chronic in the course. In postrenal kidney problems, to plan the urgency of the urologic procedures, it is crucial.
