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    Rare case of dysphagia in an elderly patient
    (Blackwell Publishing, 2015) Demirci, Hakan; Kekilli, Murat; Polat, Zülfikar; Kantarcıoğlu, Murat; Uygun, Ahmet; Bağcı, Sait
    Dear Editor, Dysphagia is common in the general population, and is mostly a result of mechanical obstruction and motility disorders.1 Dysphagia is an increasing health concern in older individuals. Dysphagia risk increases with progressing age. Adults aged older than 65 years show an increased prevalence of complications, such as malnutrition and aspiration pneumonia. The prevalence of swallowing disorders, or dysphagia, in older individuals ranges from 7% to 22%, and dramatically increases to 40–50% in older individuals who reside in long-term care facilities.
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    Reply to: Renal impairment during the treatment of telaprevir with peginterferon and ribavirin in patients with chronic hepatitis C
    (Blackwell Publishing Ltd, 2014) Sakin, Yusuf Serdar; Polat, Zülfikar; Demirci, Hakan; Kekilli, Murat; Uygun, Ahmet; Bağcı, Sait
    Dear Editor, We read with great interest the recently published article by Fukuda et al. 1 The authors indicate that there is significant correlation between serum telaprevir (TVR) level and bodyweight and suggest that adjustment of TVR dose according to bodyweight would avoid renal impairment during treatment. Herein, we want to present a case in which renal impairment completely reversed after discontinuation of TVR, and ribavirin dose reduction seemed to be important in improving renal impairment until therapy.
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    The efficacy of mesenchymal stem cell transplantation in caustic esophagus injury: an experimental study
    (SAGE Publications Inc., 2014) Kantarcıoğlu, Murat; Çalışkan, Bahadır; Demirci, Hakan; Karacalioğlu, Özgür; Kekilli, Murat; Polat, Zülfikar; Günal, Armağan; Akıncı, Melih; Uysal, Çağrı; Eksert, Sami; Gürel, Hasan; Çelebi, Gürkan; Avcu, Ferit; Ural, Ali Uğur; Bağcı, Sait
    Introduction. Ingestion of corrosive substances may lead to stricture formation in esophagus as a late complication. Full thickness injury seems to exterminate tissue stem cells of esophagus. Mesenchymal stem cells (MSCs) can differentiate into specific cell lineages and have the capacity of homing in sites of injury. Aim and Methods. We aimed to investigate the efficacy of MSC transplantation, on prevention of esophageal damage and stricture formation after caustic esophagus injury in rats. 54 rats were allocated into four groups; 4 rats were sacrificed for MSC production. Group 1, untreated controls (n: 10). Group 2, membrane labeled MSCs-treated rats (n: 20). Group 3, biodistribution of fluorodeoxyglucose labeled MSCs via positron emission tomography (PET) imaging (n: 10). Group 4, sham operated (n: 10). Standard caustic esophageal burns were created and MSCs were transplanted 24 hours after. All rats were sacrificed at the 21st days. Results. PET scan images revealed the homing behavior of MSCs to the injury site. The histopathology damage score was not significantly different from controls. However, we demonstrated Dil labeled epithelial and muscle cells which were originating from transplanted MSCs. Conclusion. MSC transplantation after caustic esophageal injury may be a helpful treatment modality; however, probably repeated infusions are needed. © 2014 Murat Kantarcioglu et al.