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Öğe A case of asymptomatic ileal duplication cyst associated with acute appendicitis(Elsevier Inc., 2017) İpek, Hülya; Doğan, Gül; Yılmaz, Dilek; Metin , Mehmet; Afşarlar, Çağatay EvrimDuplications of the alimentary tract are infrequent anomalies. They are most frequently located in the terminal ileum, and majority of them became symptomatic before the age of 2. Presenting symptoms may include abdominal mass, intestinal obstruction, intussusception, rectal bleeding, and abdominal pain. Preoperative diagnosis is usually difficult, intra-abdominal duplications are usually diagnosed during surgical explorations of above complications. We presented a 12-year-old girl with asymptomatic ileal duplication cyst associated with non-complicated acute appendicitis, whose imaging studies at admission were compatible with complicated perforated appendicitis. © 2017 The AuthorsÖğe Comparison of the effects of Neostigmine and Sugammadex on Colonic Anastomotic Strength in Rats(Academic Press Inc., 2020) Doğan, Gül; Doğan, Güvenç; Kayır, Selçuk; Yağan, Özgür; Hancı, VolkanBackground:After colorectal surgery, anastomotic leakage is a major cause of mortality andmorbidity. There are many factors affecting anastomotic leakage. It is known that agentssuch as neostigmine that is used to reverse neuromuscular blockade have certain effectson anastomosis. In our study, in which we planned to test this hypothesis, we aimed tocompare the possible effects of different doses of sugammadex and neostigmine on colonanastomosis strength in a colonic resection anastomosis model in rats.Materials and methods:Forty adult Wistar albino male rats were divided into five groups ascontrol (group C), Sugammadex 16 mg/kg (group SL), sugammadex 96 mg/kg (group SH),neostigmine 0.3mmol/kg (group NL), and neostigmine 1.5mmol/kg (group NH). The trans-verse colons of all rats were resected, and colonic anastomosis was performed. Appropriatedrug doses according to the groups were given on the postoperative seventh day, and tissuehydroxyproline (TH) level and anastomotic bursting pressure were measured.Results:Anastomotic bursting pressure values were statistically significantly different be-tween the groups (P¼0.001). The bursting pressure in group SH was significantly highercompared with group C, group NL, and group NH. The hydroxyproline values were sta-tistically significantly different between the groups (P¼0.015). According to the post hoctest results, the difference was between group SH and group C (P¼0.007). There were nosignificant differences between the other groups (P>0.05). There was no significant dif-ference in terms of intra-abdominal adhesion rates between the groups.Conclusions:In our study, we found that low and high doses of neostigmine had no variableeffect on anastomosis, but high dose of sugammadex (96 mg/kg) had an increasing effecton intestinal anastomosis strengthÖğe Cutaneous Ciliated Cyst in an Unusual Location: Between Two Scapulas(Hindawi Ltd, 2018) Doğan, Gül; İpek, Hülya; Metin, Mehmet; Özkayar, Özgür; Afşarlar, Çağatay EvrimCutaneous ciliated cyst is defined as a rare, painless lesion frequently encountered on the lower extremities of young girls after puberty. The cyst is surrounded by the columnar ciliary epithelium. Apart from the lower extremities of girls, they may be localized on the scalp, scapula, thumb, abdomen, umbilicus, thigh, heel, knee, and gluteal region. There are two theories to explain this localization. The first is that they are mullerian heterotrophy, while the other is that they are ciliated metaplasia of eccrine glands. In this paper, we described a cutaneous ciliated cyst, which was observed with a previously undescribed localization on the back of a 13-year-old female patient.Öğe Effects of caffeic acid phenethyl ester on testicular torsion/detorsion injury in rats(Science Printers and Publishers Inc., 2018) İpek, Hülya; Doğan, Gül; Doğan, Güvenç; Deveci, EnginOBJECTIVE: To investigate the protective effect of caffeic acid phenethyl ester (CAPE) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury. STUDY DESIGN: Thirty male Wistar albino rats were randomly categorized into 3 groups: Sham, torsiondetorsion (T/D), and T/D+CAPE. Malondialdehyde (MDA), SOD, CAT, GSH levels, histopathological damage, and expression levels of endothelin-1 and ADAM-15 were examined in testicular tissue. RESULTS: The MDA level in the T/D group testes were significantly higher than those in the sham group. MDA levels of testes were lower in the CAPE-treated group than those in the T/D group. The T/D group had significantly lower SOD, CAT, and GSH levels in the testes than did the sham group. SOD, CAT, and GSH levels of the testes were lower in the CAPE-treated group than in the T/D group. In T/D group the thickness of the basal membrane in the tubules was increased, and degeneration and apoptosis in spermatogenetic cells, organization disorder in Sertoli cells, and sperm cells in the lumen were observed. The CAPE-treated group showed less atrophy and degeneration of the tubule epithelium than did the T/D group. CONCLUSION: It has been thought that CAPE administration after T/D testis damage may affect spermatogenesis development by inducing cell-cell junction by reducing apoptotic development which can regulate blood flow and microcirculation in testes. © 2018 Science Printers and Publishers, Inc.Öğe Effects of Pelargonium sidoides (UMCA ®) on pulmonary contusion from blunt thoracic trauma in rats(2020) Doğan, Gül; Doğan, Güvenç; Karaca, Onur; Ayaz, ErcanAim: The aim of the present study was to evaluate the effect of Pelargonium sidoides (UMCA ®) which was antibacterial, antiviral, anti-inflammatory and antioxidant, on pulmonary contusion (PC) caused by isolated blunt thoracic trauma (BTT) in an experimental rat model. Material and Methods: A total of 24 rats were divided into three groups: control group (CG), sham group (SG), and Pelargonium sidoidesgroup (PSG). PC was induced by isolated BTT for all the groups except the control group. Pelargonium sidoidestreatment was performed by gavage for 72 hours to the PSG after truma. Blood and tissue samples were collected from the groups. Malondialdehyde (MDA), superoxide dismutase (SOD),glutathione (GSH) and arterial blood gas parameters were measured. Lung tissue samples were collected for histopathology. Results: Histopathologically, alveolar congestion, hemorrhage,edema,disruption and neutrophil infiltrationwere significantly higher in SG when compared with CG(p<0.001, p=0.007, p=0.040, p=0.003, p=0.001). Leukocyte infiltration was significantly decreased in PSG when compared with SG (p=0.025). Biochemically, MDA level was significantly higher in SG than in CG (p<0.001) and GSH level was significantly lower in SG than in CG (p<0.001). MDA level was significantly lower in PSG than in SG (p=0.002). In blood gas parameters PH and PO2 level was significantly higher in PSG than in SG (p=0.013, p<0.001) and PCO2 level was significantly lower in PSG than in SG (p<0.001). Conclusion: PS prevents further injury by decreasing leukocyte infiltration,MDAand regulating ventilation -perfusion in lung contusions. PS may have a role in the progression of inflammation but not in preventing the pathologic disruption of pulmonary parenchyma exactly.Öğe Experimental study on prophylactic effects of vardenafil in ischemia–reperfusion model with intestinal volvulus injury in rats(W.B. Saunders, 2019) Doğan, Gül; İpek, Hülya; Baş, Yılmaz; Doğan, Güvenç; Kayır, SelçukAim: An experimental study was performed to evaluate the effects of Vardenafil on ischemia–reperfusion (I/R) injury in an experimental volvulus model by histochemical and biochemical methods. Materials and methods: Thirty-five male Wistar rats were divided in five groups (n = 7). In Group 1, a 5 cm segment of small intestine 2 cm proximal to cecum was excised to have a control group. In the second group, 5 cm segment of small intestine 2 cm proximal to cecum was rotated 360° clockwise direction and sutured with 4/0 polyglactin to generate an experimental model of volvulus. At the end of 2 h of ischemia, the same intestinal segment was sampled. In group 3, after achieving ischemia similar to group 2, two hours of reperfusion injury was obtained by removing the sutures. Rats in Group 4 received vardenafil after 1.5 h of ischemia and then 2 h of reperfusion. And finally, in Group 5, vardenafil was administered 2 h before laparotomy and 5 cm of intestine was removed without I/R injury. Intestinal segments were evaluated for total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) with biochemical and histopathological analysis. Results: Serum TOS levels and OSI were not significantly different between groups (p = 0.910, P = 0,43 respectively). The serum TAS level was decreased in group 3 as compared to vardenafil groups 4 and 5, without a statistical significance (p = 0.428). In histopathologic analysis, we found that vardenafil, partially reduced I/R injury. The villus structure was preserved but, congestion and inflammation were moderate. Conclusion: Vardenafil partially reduced I/R injury histopathologically on intestine. Our study shows that it does not have statistically antioxidant effect on intestinal I/R injury in experimental model of volvulus. However, effects of vardenafil in I/R injury of liver, kidney, heart, testis, over and brain which were cited in literature were not confirmed with I/R injury on intestine. © 2019 Elsevier Inc.Öğe Foreign body aspirations in children- it is a single center experience(2020) Doğan, Gül; İpek, HülyaAim: Foreign body aspiration causes serious mortality in children and is an important emergency condition requiring early diagnosis and bronchoscopy in the childhood period. In our research, we evaluated data from cases treated with the diagnosis of foreign body aspiration within 9 years in our clinic in terms of the complications during and after the procedures. This study aimed to determine the demographic and clinical characteristics of patients admitted for foreign body aspiration, to evaluate bronchoscopy findings, and to compare early and late-diagnosed patients. Material and Methods: The files of cases that underwent bronchoscopy for a suspected foreign body aspiration in our hospital from January 2010 to September 2019 were investigated retrospectively. A total of 54 children were evaluated. All the bronchoscopies were performed with general anesthesia. The patients were evaluated in terms of clinical and examination findings, radiological findings, and complications that developed during and after anesthesia. Results: Of all the patients, 63% were boys. The most common findings on admission were cough in 96.3% and respiratory problems in 33.3%. Of all the patients, 40.7% had reduced respiratory sounds on the right and 44.4% had foreign objects removed from the right main bronchus. The most commonly aspirated object was walnut. During anesthesia, the most commonly observed complication was low saturation, and laryngeal edema was most common after anesthesia. Conclusion: Rapid and systematic evaluation and referral to a center with bronchoscopy experience are considered life-saving factors for children with a suspected aspiration of a foreign body.Öğe Investigating AXIN1 gene polymorphisms in Turkish children with cryptorchidism: A pilot study(ELSEVIER SCI LTD, 2024) Doğan, Gül; Yılmaz, Akın; İpek, Hülya; Metin, Mehmet; Peltek Kendirci, Havva Nur; Afşarlar, Çağatay EvrimIntroduction Cryptorchidism is one of the most common congenital anomalies in male children, occurring in 2e5% of full-term male infants. Both genetic and environmental factors are observed to play a role in its etiology. A study conducted in Japan identified the AXIN1 gene as being associated with cryptorchidism. Objective We aimed to conduct a pilot study on AXIN1 gene polymorphism in Turkish children with cryptorchidism, and whether AXIN1 gene polymorphism is a risk factor for cryptorchidism. Study design Between January 2023 and December 2023, we have planned a prospective controlled study including 84 boys operated for cryptorchidism as study group, and 96 boys operated for circumcision as control group. The remaining blood samples of preoperative laboratory tests in ethylenediamine tetraacetic acid (EDTA) tubes were kept at 20 Co freezer for genomic studies. Patient demographics, physical examination and operative findings were recorded, study patients were grouped according to testis localization. After collecting all samples, genomic DNA isolation procedure was done, and analysis of the 3 polymorphisms (rs12921862, rs1805105 and rs370681) of AXIN1 gene was performed using conventional Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) method. Genotype and allele frequencies of each group was analyzed and compared. Results The most common location of cryptorchid testis was proximal inguinal (53%), followed by distal inguinal (25.3%), bilateral (13.3%), and intra-abdominal (8.4%). Regarding the 3 polymorphisms of AXIN1 gene, there was no significant difference between study and control groups, in terms of genotype and allele frequencies (P > 0.05). Eight haplotype blocks were estimated for 3 polymorphisms of AXIN1. However, no significant difference was observed between study and control groups regarding haplotype distributions (P > 0.05). In addition, the comparison of the localization of testis with AXIN1 gene polymorphism did not show any significant difference among cryptorchid testis groups (P > 0.05). Discussion The AXIN1 gene is located on chromosome 16p and its polymorphisms have been associated with various diseases. In a Chinese study, the rs370681 polymorphism was found to be associated with cryptorchidism. However, our results showed no association between the AXIN1 gene haplotypes for the studied polymorphisms and cryptorchidism. Conclusion In this study we have investigated the AXIN1 gene polymorphism in Turkish children with cryptorchidism as a pilot study. Although we could not identify any difference as compared to control group, further research is necessary to uncover the underlying molecular mechanisms contributing to the development of cryptorchidism.Öğe Statistical Analysis Of Covid-19 Publications In The Fields Of Pediatrics(2020) Doğan, Gül; Doğan, GüvençObjective: This study aims to conduct the statistical analysis of the scientific outputs about COVID-19 in the field of Pediatrics, identify the top effective studies, and reveal the trend topics. Material and Methods: Statistical analysis was performed for all the publications published between 2019 and 2020 in the “Pediatrics” research area in the Web of Science database and included the “COVID-19”, “SARS-CoV-2”, “2019-nCoV”, “n- CoV”, and “coronavirus” keywords in their title. Results: The literature review indicated 15140 publications, 397 (2.62%) of which were in the “Pediatrics” research area. The top 3 journals that had the highest number of publications were Pediatric Blood & Cancer, Lancet Child & Adolescent Health, Pediatric Pulmonology. The top-cited 3 articles were published in the journals of Translational Pediatrics, Pediatric Pulmonology, Acta Paediatrica. According to the trend analysis results, the trend topics included the keywords such as pregnancy, neonate(s), newborn(s), adolescents, breastfeeding, treatment, epidemiology, pneumonia, vertical transmission, asthma, breast milk, clinical characteristics, computed tomography, diagnosis, human milk, infant, myocarditis, survey, and symptoms. Conclusion: The pandemic affecting the whole world has also changed the course of academic publications. This bibliometric study provided a summary of the publications about COVID-19 in the field of Pediatrics.Öğe The effect of religious beliefs on the publication productivity of countries in circumcision: A comprehensive bibliometric view(Springer, 2020) Doğan, GülCircumcision is one of the most common surgical operations in newborns, babies, and children due to cultural, religious, and medical reasons. Religious beliefs are known to have an important role in circumcision. Although bibliometric analyses have been performed about several topics with a lot of publications in literature, no studies in the literature were found to focus on male circumcision. This study aims to make a comprehensive bibliometric analysis of circumcision and investigate the relationship between publication productivity and religious beliefs of the countries. Web of Science was utilized to obtain the documents needed for bibliometric analyses. “Circumcision” keyword was used for search. The search included studies published between 1980 and 2018. The literature review indicated that there were 3694 publications about circumcision published between 1980 and 2018. Of these publications, 1770 (47.9%) were articles. This study provided a bibliometric summary of 1770 articles. The top five active countries about circumcision were the USA, England, South Africa, Turkey, and Kenya. The present study found that the religious beliefs of a country were directly related to publication productivity about circumcision. The top-cited study was the article entitled “Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomized controlled trial” written by Bailey et al. and published in the journal of Lancet. The keyword analysis results showed that HIV was the top keyword used in all articles about circumcision. This study is believed to help researchers interested in circumcision topic to access a summary of the literature, see contemporary and more important topics, and discover new ideas about the issue.Öğe The Use of Machine Learning Approaches for the Diagnosis of Acute Appendicitis(Hindawi Ltd, 2020) Akmeşe, Ömer Faruk; Doğan, Gül; Kör, Hakan; Erbay, Hasan; Demir, EmreAcute appendicitis is one of the most common emergency diseases in general surgery clinics. It is more common, especially between the ages of 10 and 30 years. Additionally, approximately 7% of the entire population is diagnosed with acute appendicitis at some time in their lives and requires surgery. The study aims to develop an easy, fast, and accurate estimation method for early acute appendicitis diagnosis using machine learning algorithms. Retrospective clinical records were analyzed with predictive data mining models. The predictive success of the models obtained by various machine learning algorithms was compared. A total of 595 clinical records were used in the study, including 348 males (58.49%) and 247 females (41.51%). It was found that the gradient boosted trees algorithm achieves the best success with an accurate prediction success of 95.31%. In this study, an estimation method based on machine learning was developed to identify individuals with acute appendicitis. It is thought that this method will benefit patients with signs of appendicitis, especially in emergency departments in hospitals.
