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  • Küçük Resim
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    Comparison of Preoperative and Postoperative Antioxidant Levels in Patients with Adenotonsillar Hypertrophy
    (2020) Ekinci, Adnan; Dağıstan, Hakan; Aksoy, Ahmet; Ekinci, Halil
    Objective: This study aimed to compare the serum oxidative stress levels of patients with adenotonsillar hypertrophy (ATH) with those of controls and to investigate the effects of adenotonsillectomy on the oxidative stress levels. Material and Methods: Thirty healthy children (mean age, 6 years) and 30 patients with ATH (mean age, 7 years) aged 2-12 years were included in the study. Serum total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase (PON) levels were compared between the patient and control groups. The preoperative and postoperative levels were also compared within the patient group. Results: The TOS and OSI levels were significantly higher in the patient group than in the control group (p=0.007 and p=0.027, respectively). There was no significant difference between the patient and control groups in terms of the TAS and PON levels (p=0.399 and p=0.237, respectively). The TOS and OSI levels in the patient group were significantly higher in the preoperative than in the postoperative period (p=0.005 and p=0.023, respectively), whereas there were no significant differences in the TAS and PON levels between the preoperative and postoperative period (p=0.192 and p=0.262, respectively). Conclusion: These findings demonstrate that patients with ATH are exposed to high levels of oxidative stress and that adenotonsillectomy normalizes the oxidative stress.
  • Küçük Resim
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    Serum prolidase and oxidative stress levels in patients with recurrent aphthous stomatitis: a prospective, controlled study
    (Wolters Kluwer Medknow Publications, 2020) Ekinci, Adnan; Demir, Emre; Ekinci, Halil
    Background: Recurrent aphthous stomatitis is a common disease characterized by single or multiple, self-healing, well-circumscribed, periodic ulcers occurring in the oral cavity. Although the relationship between recurrent aphthous stomatitis and oxidative stress has been extensively reviewed in the past, its relationship with prolidase enzyme levels has not been previously investigated. Aim: The aim of this study is to investigate plasma antioxidant status and prolidase enzyme levels in patients with recurrent aphthous stomatitis. Methods: The serum total oxidant status, total antioxidant status, oxidative stress index, prolidase and paraoxonase levels of 34 recurrent aphthous stomatitis patients (mean age 35.1) and 34 healthy controls (mean age 37.7) were compared in this study.Results: Total oxidant status was significantly higher in the recurrent aphthous stomatitis group (P < 0.005). The mean total oxidant status value was 5.19 mmol/L in the recurrent aphthous stomatitis group, while it was 2.90 mmol/L in the control group. Oxidative stress index was significantly higher in the recurrent aphthous stomatitis group (P = 0.016*). The mean oxidative stress index level was 0.28 AU in the recurrent aphthous stomatitis group, while it was 0.18 AU in the control group. When control and patient groups were compared, there was no significant difference between groups with regard to the total antioxidant status (P = 0.343). The total antioxidant status levels were 1.09 and 1.14 mmol/L in control and patient groups, respectively. There was no statistically significant difference between PON1 levels of recurrent aphthous stomatitis and control groups (P = 0.218). Mean PON1 levels were 326 /L in the recurrent aphthous stomatitis group and 381 U/L in the control group. Prolidase levels were not significantly different between recurrent aphthous stomatitis and control groups (P = 0.955). The mean prolidase level was 219.79 U/L in the recurrent aphthous stomatitis group and 219.26 U/Lin the control group Limitations: The limitation of this study is the small size of both patient and control groups and exclusion of pediatric patients., Similar studies performed in pediatric patient populations with a comparison to adults may be useful in providing meaningful results.Conclusions: We detected that the total oxidant status and oxidative stress index was higher in patients with recurrent aphthous stomatitis as compared to healthy controls. We could not demonstrate a significant difference in total antioxidant status, PON1 and prolidase values.