Yazar "Ersoy, Osman" seçeneğine göre listele

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    Association of Low Fecal Elastase-1 and Non-Ulcer Dyspepsia
    (Mdpi, 2018) Tahtaci, Mustafa; Koseoglu, Huseyin; Alisik, Murat; Yurekli, Oyku Tayfur; Tahtaci, Gozde; Erel, Ozcan; Ersoy, Osman
    Non-ulcer dyspepsia (NUD) is a term used to define a set of symptoms that are believed to originate from the gastroduodenal region, and no underlying organic, systemic, or metabolic reason can be found. The majority of patients suffer from chronic symptoms although half of the patients report improvement in symptoms with time. The potential role exocrine pancreatic insufficiency in NUD patients has not been clarified yet. We aimed to identify exocrine pancreas function with pancreatic fecal elastase-1 in patients diagnosed with non-ulcer dyspepsia and no typical exocrine pancreatic insufficiency (EPI) symptoms. Thirty-five patients referred to gastroenterology clinics with NUD and 35 people with no dyspeptic symptoms as a control group were included in this prospective study. Non-ulcer dyspepsia patients were classified as group 1 and control subjects classified as group 2. Upper gastrointestinal endoscopies were performed in both groups. Assessment of exocrine pancreatic function was performed by measuring fecal elastase-1 concentration with a commercial ELISA kit using polyclonal antibodies (BioServ Diagnostics) in NUD patients compared to control subjects. Mean fecal elastase-1 levels were significantly lower in group 1 patients compared with group 2 (367.47 +/- 43.27; 502.48 +/- 50.94 respectively; p = 0.04). The percentage of the patients with EPI was significantly higher in group 1 (p = 0.02). Patients with NUD should be re-evaluated if they do not show satisfactory improvement with treatment. Exocrine pancreatic insufficiency was significantly higher in patients with NUD in our study. Evaluation for the presence of EPI can be a cost effective approach in management of refractory patients during the process of ruling out organic reasons.
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    Öğe
    The predictive value of neutrophil-lymphocyte ratio and mean platelet volume in patients with colorectal carcinoma
    (2020) Köseoğlu, Hüseyin; Akar, Mustafa; Sarı, Sevil Özer; Solakoğlu, Tevfik; Polat, Yunus Halil; Tahtacı, Mustafa; Ersoy, Osman
    Aim: This study aimed to investigate neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV) for predicting colorectal cancer (CRC). Material and Methods: We investigated retrospectively patients who underwent colonoscopy. The study consisted of 75 patients with CRC and 91 study participants with normal colonoscopy as control group, and MPV and NLR were compared between groups. MPV and NLR were also investigated for tumor stage and metastasis. Results: Among the CRC patients the mean NLR value (3.09 vs 2.26) and PLT count (287080 vs 251857) were significantly higher, whereas the mean MPV (9.62 vs 10.68 fL) and hemoglobin level (11.62 vs 14.18 g/dl) were significantly lower in the CRC group. WBC count was not significantly different between the groups. Mean NLR in metastatic patients and non-metastatic patients were 3.56 and 2.73, respectively (p:0.01). Conclusion: We showed that high NLR and low MPV are associated with CRC. Elevated NLR is related with presence of CRC and it can be used for risk prediction. Although we found lower MPV levels, conflicting results about MPV in CRC prevents it from using as a marker in CRC.