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Öğe A Clinical Research on the Impact of Dexamethasone Versus Dexamethasone-Metoclopramide Combination in Reducing Postoperative Vomiting and Nausea After Cranial Surgery(Cureus Inc, 2021) Eryilmaz, Fahri; Farooque, UmarIntroduction This brief study shows the consumption of two medications that are related to those patients who have gone through the complicated procedure of craniotomy. The basic aim of these drugs is to subside the aftereffects of the procedure like postoperative nausea and vomiting in patients. Hereby, the study outlines the functional efficiency of dexamethasone along with the metoclopramide and dexamethasone alone. Materials and methods Randomly two groups were listed of 120 patients that have undergone elective craniotomy with ASA I-II. These groups were called out as group A and group B. Group A was under the medication of combination of dexamethasone and metoclopramide 8 mg and 10 mg, respectively, induced separately while group B was induced with 8 mg of dexamethasone along with 2 ml of normal saline. These drugs were induced right before anesthesia. The procedure from here on gets the same for both groups. After the surgical approach, a verbal evaluation was taken from the members of each group to collect specific data accordingly within the first 24 hours. As the method is double-blinded thus the patients were unaware of the ongoing research study. In any case of a mishap, rescue antiemetic drugs were also considered for the patients who would have experienced uncontrolled nausea and vomiting in the timeframe. Results The results show that only 16.7% of the patients from group A showed signs of nausea and only 5% showed vomiting while 31.7% of the patients from group B showed signs of nausea and 11.7% showed vomiting. It clearly showed that the patients tend to have either no sign of nausea and vomiting or showed little controllable nausea and vomiting when induced with dexamethasone and metoclopramide compared to those who were induced with the dexamethasone alone. Conclusions Postoperative nausea and vomiting are studied in terms of those who had undergone craniotomy. This study shows the prophylaxis of adverse effects of postoperative nausea and vomiting between the two groups under the influence of altered drugs. Thus, the results were noticeably in the favor of the combination treatment of dexamethasone and metoclopramide.Öğe Convalescent plasma therapy and donor selection for COVID-19 outbreak: A help from survivors to patients(Lahore Medical & Dental Coll, 2020) Sahin, Havva Hande Keser; Eryilmaz, Fahri; Sahin, MustafaThe Coronavirus pandemic, which began in Wuhan-China in December 2019, was evaluated with WHO data. The effectiveness of convalescent plasma therapy in the pandemic was discussed in the present review. The importance of donor selection for this treatment method was emphasized. We offer the world that convalescent plasma therapy should be developed to combat the pandemic. But not all cases have closed, and new cases continue to be diagnosed around the world. The pandemic is very aggressive, and the world is under serious threat. No vaccine or antiviral agent effective on Coronavirus has yet been produced. Each country can combine survivor-induced convalescent plasma treatment into existing treatments until the Coronavirus vaccine and antiviral agent are produced. This method can offer a time-saving treatment option for every country with its advantages such as easy applicability, low cost and limited medical equipment requirements, but vaccine-drug researches should be accelerated internationally. We believe that target donor selection will determine success in convalescent plasma treatment. Multicenter international clinical trials are needed to combat the COVID-19 pandemic and to develop convalescent plasma therapy.Öğe Scoliosis and Gastroesophageal Reflux Disease in Adults(Cureus Inc, 2021) Eryilmaz, Fahri; Ahmed, Faheem; Rehmani, Asim K.; Karimi, Sundas; Qazi, Aamna; Mustafa, Sufyan; Farooque, UmarIntroduction Degenerative scoliosis most commonly presents with lower back pain. Literature suggests that adults who have degenerative scoliosis are at greater risk of both hiatal hernia and gastroesophageal reflux disease (GERD). The objective of this study was to evaluate scoliosis as being the risk factor of GERD in adults. Materials and methods This prospective study was conducted at Dow University of Health Sciences over a period of two years (May 2018 to April 2020). The investigation included 210 participants with spinal disorders. The mean age was 71.6 +/- 9.6 years. The X-rays of the participants' whole spine were taken in a standing position, in the sagittal and corona' planes. Symptoms of GERD were measured through the quality of life and utility evaluation survey technology (QUEST) score, taking six points as cutoff values. The evaluation was done using radiographs to determine any relationship between spinal disorders and GERD. Negative values were analyzed in a right-sided convex curve while positive values in the left-sided convex curve were viewed in the coronal plane. Degenerative scoliosis was explained as a lumbar/thoracolumbar Cobb angle of more than 10 degrees. Univariate and multivariate logistic regression analyses were done to assess the risk factors related to GERD. Results Out. of 210 patients, 146 were found to have degenerative scoliosis at the level of the lumbar and thoracolumbar spine. Fifty-two patients had a right convex curve, and 94 had a left convex curve. Sixty-nine patients had GERD. According to the analysis of the multivariate logistic regression, the Cobb angle was highly related to GERD (p-value <0.05 and odds ratio of 1.031). The participants were grouped according to the Cobb angle of curve at the lumbar spine (less than 30 degrees with a large right-sided convex curve, 30 and more with a small curve, and more than 30+ degrees with a large left-sided convex curve). The study revealed that a large left-sided convex curve was highly related to GERD, with a p-value <0.05 and odds ratio of 10.935. Conclusions The left-sided large convex curve at the thoracolumbar or lumbar spine, especially when the Cobb angle was more than 30 degrees, was highly associated with GERD. Therefore, the symptoms of GERD should he monitored in the elderly population with degenerative scoliosis.Öğe Study to Determine the Significant Prognostic Factors Related with Better Clinical Outcome in Glioblastoma Multiforme Patients(Lahore Medical & Dental Coll, 2020) Eryilmaz, Fahri; Raza, Muhammad AsifAim: In adults glioblastoma multiforme (GBM) is the deadly and utmost communal brain tumor. GBM has poor prognosis and the median general endurance hardly surpasses one-year. In this study, we retrospectively assessed the demographic and clinical characteristics of patients with GBM and to recognize significant prognostic factors that may be associated with better results in our population. Material and Methods: The clinicopathological, treatment parameters (ie, chemotherapy, radiotherapy and the surgical resection extent) and demographic parameters were attained from medical records. SPSS version 23.0 was applied for all statistical analyzes. The overall survival and median progression-free survival was 14.1 and 10 months; correspondingly. Results: In the subjects with the longest overall survival group, a tumor was found in the frontotemporal area, and then in the frontal area. In a univariate analysis, age, co-administration of adjuvant temozolomide (TMZ) and chemoradiotherapy were prognosticators of both overall survival (OS) and progression-free survival (PFS). Though, in multivariate analysis, radiotherapy and age were important determinants of endurance. Subjects who received the cyber-knife after relapse had a lengthier operating system. Conclusion: The patients were retrospectively assessed with GBM in the facility, and the outcomes confirmed formerly testified factors influencing GBM endurance.
