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    Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine
    (2019) Bakırhan, Nurgül Karadaş; Akmeşe, Bediha; Göver, Tuğçe; Imanzadeh, Hamideh; Özkan, Sibel Ayşıl
    The degradation of daunorubicin (DNR), doxorubicin (DXR) and vincristine (VCR) as chemotherapeutic agents was investigated under stress conditions such as acidic and alkaline media, oxidation, photolytic and heating. The degradation pathway determined by high-performance liquid chromatography (HPLC). Daunorubicin, doxorubicin and vincristine completely disintegrated in the basic medium. It has been determined that these drugs are resistant to heat. Daunorubicin and doxorubicin are resistant to UV light. However, vincristine is not very stable such as the other two compounds against UV light. The kinetic and thermodynamic parameters of daunorubicin, doxorubicin and vincristine were investigated in neutral media with different temperatures by electrochemical technique. Enthalpy, entropy and Gibbs free energy parameters were investigated in pH 7.4 phosphate buffer (PB) solution due to stability of these drugs at this pH. The studied chemotherapeutic agents showed endothermic process on glassy carbon-based electrode surface. Daunorubicin, doxorubicin and vincristine showed strongly adsorption process in room temperature. However, it showed diffusion property from electrode to solution with increasing the temperature values.
  • [ X ]
    Öğe
    Magnetic Nanosensor Design and Assay of an Anti-Tuberculosis Drug
    (Electrochemical Soc Inc, 2019) Imanzadeh, Hamideh; Bakirhan, Nurgul K.; Habibi, Biuck; Ozkan, Sibel A.
    In the present work, an anti-tuberculosis drug, morphazinamide HCl (MRA) was investigated at ultra-trace level in real sample for the first time. Iron (III) oxide nanoparticles (Fe(2)O(3)NPs) were casted on a glassy carbon electrode (GCE) for the determination of MRA. Cyclic voltammetry, electrochemical impedance spectroscopy, transmission electron microscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy were employed for morphological characterization of the electrode surface. The results displayed a higher surface area and greater conductivity for the Fe(2)O(3)NPs modified glassy carbon electrode (Fe(2)O(3)NPs/ GCE) than bare GCE. The square wave voltammetry response of the Fe(2)O(3)NPs/GCE was linear with MRA concentration in the range of 1 mu M to 100 mu M under optimized conditions (0.1M phosphate buffer solution at pH 3.0; drop-casting volume 10 mu L; accumulation time 15 s; accumulation potential -0.3 V), with a detection limit of 0.21 nM. Also, the proposed procedure was very efficient for MRA determination from human serum sample with high recoveries. (C) 2019 The Electrochemical Society.