Yazar "Karabulut, Alpaslan" seçeneğine göre listele
Listeleniyor 1 - 6 / 6
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A Prospective Noninterventional, Observational Study to Describe the Effectiveness and Safety of Trandolapril and Verapamil Single-Pill Combination in the Management of Patients with Hypertension and Type 2 Diabetes Mellitus: A Harvest TR Study(Hindawi Ltd, 2020) Atalar, Enver; Eskin, Fatih; Tugtekin, Haci Bayram; Karabulut, Alpaslan; Kanyilmaz, Suleyman; Kirbiyik, Halil; Ozyildiz, Ali GokhanMaintaining regular blood pressure control usually requires multidrug regimens rather than monotherapy. The objective of this study was to describe the effectiveness and safety of an angiotensin-converting enzyme inhibitor and a nondihydropyridine calcium channel blocker in a single-tablet combination in patients with hypertension, a heart rate higher than 70 beats/min, and type 2 diabetes mellitus (T2DM). This study was conducted in Turkey as a prospective, noninterventional, observational study. At 22 clinical sites, the data of 200 patients with hypertension were used for efficacy analysis; however, 262 patients received at least one dose of trandolapril/verapamil fixed-dose combination at two dose strengths. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, PR interval, glycated haemoglobin (HbA1c), and albumin/creatinine ratios were recorded during 8 weeks of treatment. With treatment, the mean (+/- SD) SBP that was recorded as 162.8 (+/- 14.642) mm Hg at baseline was reduced to131.7 +/- 11.1 mm Hg at week 8 (p<0.05). Similarly, the mean DBP was reduced from93.76 +/- 9.16 mm Hg to77.6 +/- 7.6 mm Hg (p<0.001). Following 8 weeks of treatment, SBP and DBP values were reduced below 140 mm Hg and 90 mm Hg in most patients (81.5%), respectively. The mean heart rate as evaluated using electrocardiography measurements was reduced to 78.25 beats/min at week 8 as compared with baseline during trandolapril/verapamil single-pill combination treatment (p<0.001). Treatment with trandolapril and verapamil was well tolerated over 8 weeks with no unexpected safety signals. In conclusion, the single-pill combination of trandolapril and verapamil was considered effective in reducing and controlling blood pressure in patients with hypertension and T2DM. There was a significant improvement in HbA1c and ACR levels in a smaller subgroup of the patient cohort. The trandolapril/verapamil combination was evaluated as being safe and well-tolerated following a treatment period of 8 weeks. This trial was registered with NCT02298556.Öğe CRUCIAL MARKERS SHOWING THE RISK OF CORONARY ARTERY DISEASE IN OBESITY: ADMA AND NEOPTERIN(Soc Medical Biochemists Serbia, 2020) Avci, Emre; Karabulut, Alpaslan; Avci, Avci Alp; Baba, Burcu; Bilgi, CumhurBackground: Obesity is responsible for high morbidity and mortality, both in developed and developing countries. It is associated with many chronic and metabolic diseases. Asymmetric dimethylarginine (ADMA) has been demonstrated to be a biomarker of endothelial dysfunction in humans and increased ADMA associated with cardiovascular disease (CVD) risk has been reported in many states. Neopterin (NP) produced by monocytes/macrophages in response to stimulation by interferon-gamma (IFN-gamma) is emphasized in recent findings. The current study aims to investigate ADMA and NP levels which may assume a role in guiding the early diagnosis of coronary artery disease in obesity. Methods: This is an original research study in which ADMA and NP levels of 50 patients (25 male/25 female) diagnosed with obesity were compared with those of 30 healthy individuals (15 male/15 female) as control. The high-performance liquid chromatography (HPLC) method was used while determining parameters. Results: ADMA and NP levels in obese individuals were found to be significantly higher than in those enrolled in the control. ADMA values were found to be higher in obese subjects (0.71 +/- 0.24 mu mol/L) as compared with levels found in healthy subjects (0.58 +/- 0.16 mu mol/L) (p<0.05). A significant increase of serum neopterin levels was found in obese subjects (8.8 +/- 3.5 mu mol/L) as compared with controls (4.9 +/- 1.69 mu mol/L) (p<0.05). Also, there was a strong positive correlation between NP and ADMA values in obese individuals (r=0.954). Conclusions: Our study revealed that obese subjects have higher ADMA and neopterin levels. These results demonstrated that both ADMA and NP levels may be potential risk factors for coronary heart disease in obesity.Öğe Increased oxidative stress in adult women with iron deficiency anemia(TRISAKTI UNIV, FAC MEDICINE, 2022) Karabulut, Alpaslan; Alp Avcı, Gülçin; Avcı, EmreBACKGROUND Iron deficiency anemia (IDA), a type of anemia with an increasing global frequency, is more common in women than men in the population. In IDA, the sensitivity of erythrocytes to oxidants is increased and their lifespan is shortened. Oxidative stress is an imbalance between free radicals and antioxidant molecules which is one of the potential biochemical mechanisms involved in the pathogenesis of IDA. In our study, we aimed to determine the levels of oxidant and antioxidant markers by assessing the levels of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 (PON-1), and myeloperoxidase (MPO) in women with IDA. METHODS This was a cross-sectional study involving 47 women with IDA aged ?40 years and 47 women volunteers. The levels of TAS, TOS, OSI, PON-1, and MPO were determined spectrophotometrically using appropriate kits. Nonparametric Mann Whitney-U tests were used to analyze the data. RESULTS The levels of antioxidants TAS (1.42 mmol Trolox equiv./L) and MPO (54.00 U/L) in the IDA group were significantly lower than in the control group [TAS (1.67 mmol Trolox equiv./L) and MPO (89.00 U/L)] (p=0.000 and p= 0.019, respectively). However, TOS (6.25 ?mol H2O2 equiv./L) level in the IDA group was significantly higher than in the control group (4.13 ?mol H2O2 equiv./L) (p=0.000), but PON-1 was not significantly different between the two groups (p=0.375). CONCLUSION In women with IDA, the oxidant-antioxidant balance is impaired, resulting in oxidative stress. Therefore, IDA in adult women must receive adequate attention in clinical practice.Öğe Investigation of the distribution of thyroid dysfunction in the geriatric patient population in Corum province(2019) Şahin, Mustafa; Karabulut, Alpaslan; Kayadibi, HüseyinObjectives: The aim of this study was to identify and analyze the incidence of thyroid dysfunction in geriatric patients in Corum province, Turkey. Methods: The results of thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) tests, as well as the demographic characteristics of 220 randomized patients were retrospectively investigated. Patients who had a total or partial thyroidectomy surgery and those receiving any medical thyroid treatment were not included in the study. The patients were divided into 5 groups: subclinical hypothyroidism, hypothyroidism, euthyroid, subclinical hyperthyroidism, and hyperthyroidism. Results: In the group, 114 were male and 106 were female. The mean age of the male and female patients was 74±7 years and 75±7 years, respectively. The entire study group had a median TSH of 0.94 ?IU/mL (25th-75th percentile, interquartile range [IQR] 0.33-1.86 ?IU/mL), a median FT4 of 1.14 ng/dL (IQR: 1.02-1.33 ng/dL), and a median FT3 of 2.73 pg/mL (IQR: 2.25-3.11 pg/mL). For male patients, the median TSH was 0.87 ?IU/mL (IQR: 0.36-1.66 ?IU/mL), the median FT4 was 1.14 ng/dL (IQR: 1.02-1.29 ng/dL), and the median FT3 was 2.74 pg/mL (IQR: 2.18-3.15 pg/mL), while for female patients the median TSH was 0.95 ?IU/mL (IQR: 0.20-2.21 ?IU/mL), the median FT4 was 1.17 ng/dL (IQR: 1.06-1.38 ng/ dL), and the median FT3 was 2.72 pg/mL (2.31-3.10 pg/mL). Of the males, 1.8% had subclinical hypothyroidism, another 1.8% had hypothyroidism, 72.8% were euthyroid, 19.3% had subclinical hyperthyroidism, and 4.4% had hyperthyroidism. Among the females, there were findings of 2.8% subclinical hypothyroidism, 1.9% hypothyroidism, 64.2% euthyroid, 26.4% subclinical hyperthyroidism, and 4.7% hyperthyroidism. No statistically significant difference was observed when the diagnosis incidence was compared according to gender (p=0.696). Conclusion: Independent of gender, the geriatric patient population had a high incidence of subclinical hyperthyroidism, which often has a delayed diagnosis. This can complicate the prompt diagnosis of other metabolic diseases. As thyroid function affects the metabolism of the entire body, thyroid hormone status should be investigated when considering other metabolic diseases in geriatric patients. Excluding thyroid disfunction could save time in making an accurate diagnosis and providing treatment. Furthermore, since thyroid diseases are influenced by environmental iodine, regional thyroid disease incidence studies should be performed.Öğe Relationship between liver histology and platelet parameters in patients with chronic hepatitis B(2019) Çoşgun, Cihat; Karabulut, Alpaslan; Yılmaz, Barış; Köseoğlu, Hüseyin; Demir, EmrePurpose: Many noninvasive tests have been studied for the diagnosis and determining the liver fibrosis score. In this study, we aimed to research the correlation of platelet parameters and stage of liver fibrosis in patients with chronic hepatitis B (CHB). Materials and Methods: A total of 140 biopsy-proven naive CHB cases were included in the study. HBV-DNA level, liver enzymes and function tests, white blood cell count, platelet parametres, hemoglobin, histological activity index (HAI) and other routine biochemical parameters were tested. Patients were divided into two groups as F0-2 and F3-6 with Ishak scoring system according to the severity of liver fibrosis. Results: There was no significant difference between the groups F0-2 and F3-6 in terms of, platelet (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT). There was a significant difference between these two groups for HAI, aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), age and lymphocyte (LYM) parameters. The formulation of (AST x Age x LYM) / ?PLT)which was formed from many different combinations, was investigated in order to be used in predicting the liver fibrosis stage. Conclusion: Although our new index is more sensitivitythan other noninvasive scoring systems, it is needed to have a larger sample size in patients with severe stage liver fibrosis in order to be used safely as a noninvasive marker.Öğe The association between plasma concentration of pigment epithelium-derived factor and diabetic retinopathy(WALTER DE GRUYTER GMBH, 2023) Şahin, Tayfun; Karabulut, AlpaslanObjectives Diabetic retinopathy (DRP) is one of the most common microvascular complications of diabetes. The pigment epithelium-derived factor (PEDF) is a protein that is one of the most potent angiogenesis inhibitors. The effect of blood PEDF concentration on DRP formation remains unclear. The present study aimed to determine whether the plasma concentration of PEDF is effective on the appearance of DRP. Methods The present study consisted of 62 patients with diabetes mellitus and 20 healthy participants. The patient group included 28 patients with non-proliferative DRP, 13 with proliferative DRP, and 21 diabetic patients without DRP. The PEDF levels in patient serum samples were detected through the ELISA method. The body mass index of the participants was calculated. Results Serum PEDF levels of diabetic patients (1.533 ± 0.233??g/mL) were found to be lower (2.163 ± 0.343??g/mL) than healthy participants (p=0.002). The PEDF levels were similar in the DRP and non-DRP groups (p=0.337). The plasma PEDF level decreased along with the progression of DRP (p=0.001). Conclusions The PEDF concentration in the blood decreases along with the increase of DRP grade. Decreased blood concentration of PEDF may be important to predict microvascular complications. Agents containing PEDF may be used intraocularly/systemically for therapeutic purposes to prevent vascular complications of diabetes in the near future.
