Yazar "Karadeniz, TB" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Recurrent aphthous stomatitis, oxidative stress, and ischemia modified albumin: A cross-sectional study
    (LIPPINCOTT WILLIAMS & WILKINS, 2025) Öztekin, A; Öztekin, C; Şahin, HN; Karadeniz, TB; Şenel, E; Ataç, DC; Savcı, U; Neşelioğlu, S; Erel, Ö
    Recurrent aphthous stomatitis is an inflammatory disease characterized by painful ulcers on the oral mucosa. Oxidative stress is held responsible for the pathogenesis of this disease of unknown etiology. In oxidative stress, the balance between oxidant-antioxidant substances changes in favor of the oxidative side. Ischaemia modified albumin (IMA) is a new type of albumin. It occurs as a result of factors such as ischemic attacks and oxidative stress. The aim of the study was to compare IMA levels in patients with recurrent aphthous stomatitis with healthy volunteers and to investigate whether IMA has a diagnostic value in the disease. This cross-sectional study included 32 patients with recurrent aphthous stomatitis and 34 healthy volunteers of similar age and sex. Albumin and IMA levels were determined by spectrophotometric albumin cobalt binding assay in venous blood samples on the same day. IMA was expressed as absorbance unit. Receiver operating characteristic analysis was used to determine whether IMA values could be a diagnostic marker for prediction of disease. IMA values of the patient group were significantly higher than IMA values of the control group (P < .001). IMA was statistically significant in the prediction of recurrent aphthous stomatitis (P < .001). The discrimination power for IMA was very good (area under the receiver operating characteristic curve 95% CI = 0.952 [0.897-1.000]). Recurrent aphthous stomatitis, in which oxidative stress plays a role in the etiopathogenesis, is closely associated with high IMA levels. IMA levels may have diagnostic value as an indicator of oxidative stress in the disease.
  • [ X ]
    Öğe
    Thiol-disulfide parameters in recurrent aphthous stomatitis: A cross-sectional study
    (BMC, 2025) Karadeniz, TB; Öztekin, A; Öztekin, C; Şenel, E; Savcı, Ü; Neşelioğlu, S; Erel, Ö
    Background Recurrent aphthous stomatitis (RAS) is an idiopathic inflammatory condition of the oral mucosa, affecting approximately one-fifth of the population. Oxidative stress (OS) has recently been suggested to contribute to the etiopathogenesis of RAS. Thiols are potent antioxidants that play vital roles against oxidation. This study aimed to determine how OS contributes to the pathophysiology of RAS by analyzing the thiol/disulfide parameters. Methods This cross-sectional study was conducted with a total of 67 participants (31 patients with clinically diagnosed RAS and 36 healthy, age- and gender- matched controls) at a university hospital from January 2022 to June 2023. Blood samples were taken from patients during the active ulcer phase. Native thiol, total thiol, and disulfide levels were measured in the serum of patients and controls. The ratios of disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol were calculated. The parameters were compared between the groups. Results No significant differences were found between the patient and control groups regarding the calculated thiol/disulfide homeostasis parameters. A significant negative correlation was observed between age and total thiol (P < .001, r = - .572). Conclusions Although OS is widely believed to play a pivotal role in the pathogenesis of RAS, conflicting findings in the literature suggest that the underlying mechanisms may be more complex and multifaceted. Therefore, more comprehensive studies are needed to clarify the oxidant and antioxidant mechanisms in RAS.