Yazar "Karadurmus, Leyla" seçeneğine göre listele

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    A Review: New Trends in Electrode Systems for Sensitive Drug and Biomolecule Analysis
    (Taylor & Francis Inc, 2020) Ozcelikay, Goksu; Karadurmus, Leyla; Kaya, S. Irem; Bakirhan, Nurgul K.; Ozkan, Sibel A.
    Drug and biomolecule analysis with high precision, fast response, not expensive, and user-friendly methods have been very important for developing technology and clinical applications. Electrochemical methods are highly capable for assaying the concentration of electroactive drug or biomolecule and supply excellent knowledge concerning its physical and chemical properties such as electron transfer rates, diffusion coefficients, electron transfer number, and oxidation potential. Electrochemical methods have been widely applied because of their accuracy, sensitivity, cheapness, and can applied on-site determinations of various substances. The progress on electronics has allowed developing reliable, more sensitive and less expensive instrumentations, which have significant contribution in the area of drug development, drug and biomolecule analysis. The developing new sensors for electrochemical analysis of these compounds have growing interest in recent years. Screen-printed based electrodes have a great interest in electrochemical analysis of various drugs and biomolecules due to their easy manufacturing procedure of the electrode allow the transfer of electrochemical laboratory experiments for disposable on-site analysis of some compounds. Paper based electrodes are also fabricated by new technology. They can be preferred due to their easy, cheap, portable, disposable, and offering high sensitivity properties for many application field such as environmental monitoring, food quality control, clinical diagnosis, drug, and biomolecules analysis. In this review, the recent electrochemical drug and biomolecule (DNA, RNA, mu RNA, Biomarkers, etc.) studies will be presented that involve new trend disposable electrodes.
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    Development of a Surfactant/Platinum Composite for Sensitive Cardio-selective Beta Blocker Detection and their Theoretical Studies
    (Wiley-V C H Verlag Gmbh, 2019) Zahid, Anum; Bakirhan, Nurgul K.; Karadurmus, Leyla; Shah, Afzal; Ozkan, Sibel A.
    An electrooxidative behavior of beta-blocker drug esmolol was thoroughly investigated by using glassy carbon electrode modified with sodium dodecyl sulfate-based platinum nanoparticles. The designed nanosensor exhibited remarkable electro-catalytic effect by dramatically boosting the signal of the esmolol as compared to the bare electrode with detection limit up to picomolar. The effects of pH, scan rate, temperature, deposition potential, deposition time, effect of electrolyte and interfering agents were investigated to optimize conditions for getting intense signal of the analyte. Under optimized experimental conditions, a linear calibration plot for esmolol with a detection limit of 60 pM was obtained. The analyte sensing ability of the modified electrode was supported by the application of theoretical studies that showed favorable interaction between sodium dodecyl sulfate/platinum nanoparticles composite and esmolol. In this study, our aim was to developed a nanosensor for the sensitive detection of esmolol by electrochemical assay. We tried a lot of different modification style and modifiers for creating a sensitive nanosensor for esmolol. This nanosensor can be applied to the esmolol in serum sample without using any further separation, evaporation or precipitation steps. Application could apply in serum sample to test accuracy of our sensor and method. The high recovery results were observed in serum study.
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    Recent Electrochemical Assays on Cephalosporins
    (Bentham Science Publ Ltd, 2020) Karadurmus, Leyla; Esme, Kaan; Bakirhan, Nurgul K.; Ozkan, Sibel A.
    Antibiotics are an important class among drugs because they are a significant agent to deal with infections. Cephalosporins are a very important group of antibiotics in the beta-lactam class. The cephalosporins are semisynthetic antibiotics derived from products of the fungus Cephalo-sporium. Cephalosporins are classified as first, second, third, fourth, and advanced generation, based largely on their antibacterial spectrum and stability to beta-lactamases. Electrochemical methods have been used for the determination of cephalosporin just as used in the determination of many antibiotic drugs. Electroanalytical methods present generally high sensitivity, low cost, low requirements, ease of preparation of the samples in a very short time, and a short analysis time. The most commonly used types are cyclic voltammetry, differential pulse voltammetry, square wave voltammetry and linear sweep voltammetry. The aim of this review is to evaluate the advantages and uses of electroanalytical methods used in the determination of cephalosporins. In addition, current applications of the methods to the pharmaceutical analysis of cephalosporins will also be summarized in a table.