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    Çölyak Hastalarında D Vitamini Eksikliği ve Osteoporoz Sıklığı
    (2019) Kaya, Muhammed; Şipal, Selen; Polat, Umut; Sezikli, Mesut
    GİRİŞ ve AMAÇ: Çölyak Hastalığı genetiği yatkın bireylerde diyette gluten proteininin alımıyla ortaya çıkan, ince barsaklarda inflamasyonla seyreden otoimmün bir hastalıktır. Vitamin eksiklikleri ve osteoporoz da önemli bulgularındandır. Çalışmamızda takipli çölyak hastalarında vitamin D eksikliği ve osteoporoz sıklığını değerlendirmek amaçlanmıştır. YÖNTEM ve GEREÇLER: Çalışmamıza kliniğimizde çölyak tanısıyla takip edilen 18-65 yaş arası 80 hasta ve kontrol grubu olarak 45 sağlıklı birey dâhil edilmiştir. Her iki grubun demografik özellikleri, antropometrik ölçümleri, hemogram, biyokimya, vitamin B12, folat, ferritin, vitamin D düzeyleri ile hasta gruba ait TTG IgA, TTG IgG ve KMD sonuçları sistemde kayıtlı verilerden elde edilmiştir. Çölyak hastaları TTG antikor pozitifliğine göre glutensiz diyete uyumlu ve uyumsuz olarak iki gruba ayrılmıştır. Diyete uyumlu ve uyumsuz çölyak hastaları ile sağlıklı kontrol grubuna ait veriler karşılaştırılarak SPSS 22 istatistik programı ile analiz edilmiştir. BULGULAR: Diyete uyumlu ve uyumsuz hasta grupları ile kontrol grubu yaş cinsiyet ve sigara kullanımı açısından benzer özelliklerdedir. Diyete uyumsuz çölyak hastalarında vücut ağırlığı, karaciğer fonksiyon testleri, hemogram ve anemi parametrelerinin kötüleştiği, diyete uyum gösteren hastalarda ise sağlıklı popülasyona benzer olduğu görülmektedir. Çalışmamızda çölyaklılarda vitamin D eksikliği yüksek oranda (%73,8) saptanmış, ancak sağlıklı kontrollerden farksız bulunmuştur. Çölyak hastalarının %55,1’inde osteopeni, %17,9’unda osteoporoz saptanmıştır. Glutensiz diyete uyumlu hastalarda %8,9 olan osteoporoz oranı diyete uymayan hastalarda %30,3 olarak saptanmış ve anlamlı ölçüde artış görülmüştür. TARTIŞMA ve SONUÇ: Diyete uyumsuz hastalarda hemogram, biyokimya, folat ve ferritin parametreleri anlamlı ölçüde bozulmaktadır. Vitamin D eksikliği hem çölyaklılarda hem de sağlıklı popülasyonda sık görülmektedir ancak çölyak hastalığı ve diyet uyumu ile ilişkisi saptanamamıştır. Osteoporoz, çölyak hastalarında sık görülmekte olup diyete uyumsuz hastalarda anlamlı ölçüde artmaktadır
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    Öğe
    Evaluation of YouTube Videos as a Source of Information on Hepatosteatosis
    (CUREUS INC, 2023) Tutan, Duygu; Kaya, Muhammed
    Introduction Individuals frequently turn to YouTube as a source of information about their medical conditions and potential treatment options. Among the common ailments affecting the general population, hepatosteatosis stands out due to its severe consequences in the absence of proper treatment. The primary objective of this study is to evaluate the quality of hepatosteatosis-related videos available on the YouTube platform, and the secondary objective is to determine if there is a difference in video quality between videos uploaded by medical professionals and other sources. Methods The process of selecting videos for this study involved evaluating their relevance after conducting a search using the keywords "hepatosteatosis," "fatty liver," and "hepatic steatosis" on YouTube. This search was conducted on August 18, 2023. From the search results, we identified and selected the top 50 most-watched videos in the English language. These selected videos were then rigorously assessed for their relevance and content by three independent medical professionals. Additionally, various descriptive attributes of each video, such as the upload date, subscriber count, view count, likes, dislikes, and comments, were meticulously recorded in the dataset. To determine the quality of these videos, we utilized three evaluation tools: the DISCERN Score, the Global Quality Score (GQS), and the Journal of the American Medical Association (JAMA) rating scales. We have used the median±interquartile range (IQR), mean±standard deviation (SD), and the range of minimum to maximum values to convey descriptive statistics. The distribution was evaluated with the Shapiro-Wilks test. Spearman correlation analysis was used to identify relationships between variables. The association between quality indicators and data was examined using multiple regression analysis. The Mann-Whitney U test was used to determine significant differences between groups. A statistical significance level of 0.05 was considered significant. Results Our study revealed notable statistical differences in DISCERN scores when comparing videos uploaded by medical doctors to those uploaded by individuals without medical qualifications (p < 0.001). Likewise, in the comparisons between these two groups, videos created by healthcare professionals consistently demonstrated significantly higher quality scores in both the JAMA and GQS evaluations (p < 0.001 for both comparisons). This suggests that videos uploaded by medical professionals tend to provide higher-quality information on the topic of hepatosteatosis compared to those uploaded by non-medical individuals. Video length and comment counts were also found to be significant in the multivariate linear regression analysis and were predictive of the DISCERN score (p = 0.047 and p = 0.037, respectively). Conclusions The quality of information related to hepatosteatosis on YouTube varies significantly. Surprisingly, there is no noticeable difference in terms of views and popularity between helpful and potentially misleading videos. For individuals seeking reliable information, it is advisable to prioritize videos uploaded by medical professionals. Paying attention to the qualifications of the content creator rather than the video's popularity or view count is crucial when seeking accurate and trustworthy information on hepatosteatosis.
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    Global Publication Trends and Research Hotspots of the Gastric Neuroendocrine Neoplasms: A Bibliometric Analysis of the Current Situation
    (Pera Yayincilik Hizmetleri, 2024) Köseoğlu, Hüseyin; Kaya, Muhammed; Durak, İbrahim; Düzenli, Tolga; Kaymazlı, Mustafa; Sezikli, Mesut
    Objective: Gastric neuroendocrine neoplasms (gNENs) are uncommon tumors, with growing understandings about the disease. Bibliometric analyzes have the advantage of visually depicting the dynamic evaluation of scientific knowledge of a specific topic. The aim of this study was to perform and report bibliometric analysis of gNENs, which was not formerly studied in the literature. Methods: Articles published between 1980 and 2022 within the database of Web of Science Core Collection were included in this bibliometric analysis. Vosviewer package program and Datawrapper were used for bibliometric data interpretation. Results: A total of 2270 articles about gNENs was detected with 63240 citations and an H index of 103. A remarkable increase was detected among the articles for years. Research have focused on gastroenterology and hepatology, endocrinology and metabolism, oncology, general medicine, pathology and surgery areas. Norwegian University of Science Technology was the leading institution about gNENs literature. Modlin IM, had the highest number of articles and citations among the authors. United States, Japan and Italy were the top three countries with the most published articles. Conclusion: This bibliometric study provides an engrossing, insightful conclusion to the research and development trajectory in gNENs with a future perspective.
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    The Effect of Switch Treatment on Liver Fibrosis and qHBsAg Levels in Patients with Chronic Hepatitis B
    (2020) Yeşilyurt, Esra; Kaya, Muhammed; Dindar, Gökhan; Açıkgöz, Seyyid Bilal; Güzelbulut, Fatih; Sezikli, Hayrunnisa; Sezikli, Mesut
    Objectives: The aim of this study was to evaluate the relationship between clinical, biochemical, serological parameters, fibroscan imaging in terms of fibrosis and quantitative hepatitis B surface antigen (qHBsAg) levels in patients with chronic hepatitis B (CHB) infection whose treatment has been switched from LAM to TDF. Materials and Methods: The study included 19 patients with CHB and under the LAM treatment. The gender, age, comorbidity, medications, routine laboratuary, creatinine clearance, bone mineral density, transient elastography for stage of liver fibrosis and qHBsAg level were examined. Results: Ten of 19 patients were female and 9 were male. When the qHBsAg titers of the patients at $6^th$ and $12^th$ months were compared, there was a statistically significant decrease in qHBsAg titers of the patients after the $12^th$ month. There was a significant decrease in liver fibrosis measurements at the $12^th$ month of treatment change. There was a statistically significant positive correlation between qHBsAg titers and fibroscan values at baseline and $12^th$ month Conclusion: In this study, the replacement of LAM with TDF may prevent the resistance problem, and also the decrease in fibrosis values and/or qHBsAg levels may contribute to the prevention of HCC and cirrhosis have been showed