Yazar "Kekilli, Murat" seçeneğine göre listele
Listeleniyor 1 - 12 / 12
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Dasatinib-induced severe hemorrhagic colitis in chronic myeloid leukemia(Akademi Doktorlar Yayınevi, 2016) Kekilli, Murat; Tanoğlu, Alpaslan; Kızıl Çakar, Merih; Güney, Güven; Haznedaroğlu, İbrahim C.Dear Editor, Dasatinib is an orally administered, potent, secondline tyrosine kinase inhibitor which is used for treating imatinib resistant or intolerant chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia.Öğe Esomeprazole: A safe alternative to lansoprazole allergy?(Iranian Journal of Allergy, Asthma and Immunology, 2014) Kara, Muammer; Tanoğlu, Alpaslan; Kutlu, Ali; Sirkeci, Özgür; Kekilli, MuratProton pump inhibitors (PPIs) are widely prescribed drugs in daily practice. Allergic reactions, even small number of anaphylactic reactions to PPIs have been reported. Omeprazole, lansoprazole, pantoprazole, rapeprazol and esomeprazole are classified in the same group. Despite the similarity of biochemical structures among these drugs, presence of cross-reactivity between PPIs is controversial.1,2 In this letter, we present 3 lansoprazole allergy cases, who were prescribed and took esomeprazole safely after allergic reactions to lansoprazole.Öğe Geçirilmiş adenotonsillektomi öyküsü helicobacter pylori gastriti için koruyucu bir etken midir?(Bilimsel Tıp Yayınevi, 2019) Güney, Güven; Baş, Yılmaz; Kekilli, Murat; Demir, EmreGiriş: Helicobacter pylori tüm dünyada görülen, dünya nüfusunun yaklaşık yarısını etkileyen gram-negatif bir basildir. Yapılan çalışmalarda adenotonsiller bölgenin H. pylori için bir kolonizasyon alanı olduğu ve bulaşta etkili olduğu ileri sürülmüştür. Bu hipotezden hareketle, geçirilmiş adenotonsillektomi öyküsü (ATÖ)’nün midede H. pylori kolonizasyonu için koruyucu bir etken olabileceğini belirten çalışmalar mevcuttur. Bu çalışmamızda geçirilmiş ATÖ’nün H. pylori gastriti açısından koruyucu bir etken olup olmadığını belirlemeye çalıştık. Materyal ve Metod: Çalışmaya, Hitit Üniversitesi Çorum Erol Olçok Eğitim ve Araştırma Hastanesi Gastroenteroloji Kliniğine dispeptik şikayetlerle ilk kez başvuran ve antrumdan endoskopik biyopsi alınan (75’inde ATÖ olan, 75’inde ATÖ olmayan) toplam 150 hasta dahil edildi. Hastalardan alınan endoskopik biyopsiler hematoksilen eozin (HE) ve H. pylori varlığını saptamak için doku Giemsası ile boyanarak bütün olgular aynı patolog tarafından Sydney Update sistemine göre değerlendirildi. Bulgular: ATÖ olan hastaların yaşı 22-80 arasında değişmekte olup ortalaması 46.5 (± 17.5 SS) yıl iken, ATÖ olmayan grubun yaşları ise 24-75 yıl arasında değişmekte olup ortalaması 38.3 (± 14.0 SS) yıl idi. Yaş açısından saptanan fark istatistiksel olarak anlamlı bulunmuştur. ATÖ olmayan 75 hastanın 52 (%69)’sinde H. pylori gastriti saptanırken, ATÖ olan 33 (%44) hastada H. pylori gastriti saptanmış ve bu fark istatistiksel olarak anlamlı bulunmuştur (p= 0.021). Her iki gruptaki tüm hastaların dahil edildiği karşılaştırmada ATÖ öyküsü olmayan grupta H. pylori yoğunluğu ortalaması 1.6 iken, olan grupta H. pylori yoğunluğu ortalaması 0.8 olarak saptanmış ve bu fark istatistiksel olarak anlamlı bulunmuştur (p= 0.012). Her iki gruptaki sadece H. pylori gastriti saptanan hastalardaki H. pylori yoğunluğu karşılaştırıldığında ise ATÖ öyküsü olmayan grubun ortalaması 2.3 iken, olan grubun ortalaması 1.8 olarak saptanmış ve bu fark da istatistiksel olarak anlamlı bulunmuştur (p= 0.022). Sonuç: H. pylori için adenotonsiller bölgenin bir kolonizasyon alanı olduğu birçok çalışmada değişik yöntemler kullanılarak gösterilmiştir. Çalışmamızda ATÖ’nün bu bölgedeki kolonizasyonu engelleyeceği için H. pylori bulaşını azaltacağı ve H. pylori gastriti açısından koruyucu bir rol oynayabileceği sonucuna varılmıştır.Öğe Idiopathic varicosity of the abdominal wall(Journal of Clinical and Analytical Medicine, 2015) Diken, Adem İlkay; Yalçınkaya, Adnan; Kekilli, MuratSıklıkla inferior vena kavanın patolojilerine eşlik eden abdominal kollateral venöz yapılara klinikte sıklıkla rastlanmaktadır. Olgumuz olan 73 yaşında bayan hasta genel durum bozukluğu nedeniyle hastaneye başvurdu...Öğe Is Computerized Tomography better than fiberoptic gastroscopy for early detecting of gastric varices ?(Wiley-Blackwell, 2013) Kekilli, Murat; Suvak, Burak; Okten, Sarper[Abstract Not Available]Öğe Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?(Baishideng Publishing Group Inc., 2015) Kekilli, Murat; Tanoğlu, Alpaslan; Sakin, Yusuf Serdar; Kurt, Mevlüt; Öcal, Serkan; Bağcı, SaitAIM: To determine the association between the neutrophil to lymphocyte (N/L) ratio and the degree of liver fibrosis in patients with chronic hepatitis B (CHB) infection. METHODS: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver fibrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the "no/minimal liver fibrosis" group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the "advanced liver fibrosis" group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically significant. RESULTS: Three experienced and blinded pathologists evaluated the fibrotic status and inflammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the "no/minimal fibrosis" group included 79 individuals, while the "advanced fibrosis" group included 50 individuals. Mean (N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal fibrosis. CONCLUSION: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB. © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.Öğe Nitric oxide is a potential mediator of hepatic inflammation and fibrogenesis in autoimmune hepatitis(Informa Healthcare, 2015) Beyazıt, Yavuz; Efe, Cumali; Tanoğlu, Alpaslan; Purnak, Tuğrul; Sayılır, Abdurrahim; Taşkıran, İsmail; Kekilli, Murat; Turhan, Turan; Özaslan, Ersan; Wahlin, StaffanBackground. Despite advances in the understanding of the pathophysiological basis of autoimmune hepatitis (AIH), it is still difficult to delineate the mechanisms involved in progression from hepatic inflammation toward fibrosis. Our aim was to study serum concentrations of NO in AIH of different histological severity and possible effects of immunosuppressive therapy on NO production. Materials and methods. We studied serum NO metabolites (NOx) in 47 consecutive patients with AIH and in 28 age- and sex-matched controls. Results. Serum NOx concentrations were higher in AIH patients than in controls (10.3 (4.5-27.3 µmol/L) vs. 4.3 (1.6-14.3 µmol/L), p < 0.001). According to liver histology, median NOx concentrations were significantly higher in patients with severe interface hepatitis compared to patients with mild-moderate interface hepatitis (12.3 (4.5-27.3 µmol/L) vs. 9.3 (4.6-20.3 µmol/L), p = 0.029). Similarly, serum NOx concentrations were significantly higher in patients with advanced fibrosis than in those with early fibrosis (12.2 (4.6-27.3 µmol/L) vs. 9.3 (6.6-12.8 µmol/L), p = 0.018). NOx concentrations decreased in 16 AIH patients who were tested also after biochemical remission was achieved (12.6 (4.5-22.8 µmol/L) at baseline and 5.9 (2.8-10.5 µmol/L) after remission, p = 0.001). Conclusion. This study shows that serum NOx levels are associated with the histological severity of AIH. Hepatocyte inflammation and injury may activate hepatic stellate cells and kupffer cells, and the consequences may include release of NO, which ultimately promotes hepatic fibrosis. Immunosuppressive therapy inhibits this process and the production of NO. © 2015 Informa Healthcare.Öğe Rabeprazole-induced tinnitus(SAGE Publications Inc., 2014) Kekilli, Murat; Tanoğlu, Alpaslan; Özal, Serkan; Beyazıt, YavuzTO THE EDITOR: Tinnitus could be defined as perception of noise sensation of sound in the absence of a corresponding external acoustic stimulus.1 Rabeprazole is a proton pump inhibitor used to treat acid-related gastrointestinal disorders including esophagitis, peptic ulcer, and gastroesophageal reflux disease (GERD). As a class of proton pump inhibitors, it has been implicated in several case reports as a cause of colestatic liver injury2 and acute interstitial nephritis.3 To date, rabeprazole-induced tinnitus has not been described.Öğe Rare case of dysphagia in an elderly patient(Blackwell Publishing, 2015) Demirci, Hakan; Kekilli, Murat; Polat, Zülfikar; Kantarcıoğlu, Murat; Uygun, Ahmet; Bağcı, SaitDear Editor, Dysphagia is common in the general population, and is mostly a result of mechanical obstruction and motility disorders.1 Dysphagia is an increasing health concern in older individuals. Dysphagia risk increases with progressing age. Adults aged older than 65 years show an increased prevalence of complications, such as malnutrition and aspiration pneumonia. The prevalence of swallowing disorders, or dysphagia, in older individuals ranges from 7% to 22%, and dramatically increases to 40–50% in older individuals who reside in long-term care facilities.Öğe Reply to: Renal impairment during the treatment of telaprevir with peginterferon and ribavirin in patients with chronic hepatitis C(Blackwell Publishing Ltd, 2014) Sakin, Yusuf Serdar; Polat, Zülfikar; Demirci, Hakan; Kekilli, Murat; Uygun, Ahmet; Bağcı, SaitDear Editor, We read with great interest the recently published article by Fukuda et al. 1 The authors indicate that there is significant correlation between serum telaprevir (TVR) level and bodyweight and suggest that adjustment of TVR dose according to bodyweight would avoid renal impairment during treatment. Herein, we want to present a case in which renal impairment completely reversed after discontinuation of TVR, and ribavirin dose reduction seemed to be important in improving renal impairment until therapy.Öğe The efficacy of mesenchymal stem cell transplantation in caustic esophagus injury: an experimental study(SAGE Publications Inc., 2014) Kantarcıoğlu, Murat; Çalışkan, Bahadır; Demirci, Hakan; Karacalioğlu, Özgür; Kekilli, Murat; Polat, Zülfikar; Günal, Armağan; Akıncı, Melih; Uysal, Çağrı; Eksert, Sami; Gürel, Hasan; Çelebi, Gürkan; Avcu, Ferit; Ural, Ali Uğur; Bağcı, SaitIntroduction. Ingestion of corrosive substances may lead to stricture formation in esophagus as a late complication. Full thickness injury seems to exterminate tissue stem cells of esophagus. Mesenchymal stem cells (MSCs) can differentiate into specific cell lineages and have the capacity of homing in sites of injury. Aim and Methods. We aimed to investigate the efficacy of MSC transplantation, on prevention of esophageal damage and stricture formation after caustic esophagus injury in rats. 54 rats were allocated into four groups; 4 rats were sacrificed for MSC production. Group 1, untreated controls (n: 10). Group 2, membrane labeled MSCs-treated rats (n: 20). Group 3, biodistribution of fluorodeoxyglucose labeled MSCs via positron emission tomography (PET) imaging (n: 10). Group 4, sham operated (n: 10). Standard caustic esophageal burns were created and MSCs were transplanted 24 hours after. All rats were sacrificed at the 21st days. Results. PET scan images revealed the homing behavior of MSCs to the injury site. The histopathology damage score was not significantly different from controls. However, we demonstrated Dil labeled epithelial and muscle cells which were originating from transplanted MSCs. Conclusion. MSC transplantation after caustic esophageal injury may be a helpful treatment modality; however, probably repeated infusions are needed. © 2014 Murat Kantarcioglu et al.Öğe The use of prealbumin as a predictor of malnutrition in cirrhotic patients and the effect of nutritional support in patients with low prealbumin levels(2020) Dağ, Zuhal; Köseoğlu, Hüseyin; Kekilli, MuratBackground/aim: Malnutrition is an important and commonly seen prognostic factor in patients with cirrhosis. The diagnosis of malnutrition in cirrhosis patients may be challenging, and an easily measured and widely usable marker is lacking. Prealbumin, however, is an easily measured marker. In the current study we measured prealbumin levels in cirrhotic patients with no clinically apparent malnutrition and used it as a malnutrition marker. Another aim of this study was to evaluate the effect of nutritional support on patient with low prealbumin levels. Materials and methods: Fifty-two patients with Child A and Child B cirrhosis were selected for the study. Prealbumin levels were studied, and Child and MELD scores were calculated. Patients with prealbumin levels ?180 mg/L were considered to have malnutrition, and two different types of nutritional products were given to these patients. The patients given nutritional support were investigated a month later, and parameters were compared. Results: According to the prealbumin threshold of 180 mg/L, malnutrition frequencies were 59.3% for Child A and 95% for Child B cirrhosis. After the provision of nutritional support statistically significant improvements in albumin and INR levels were detected. In addition, the MELD score decreased; however, it was not statistically significant (P: 0.088). A statistically significant decrease in the MELD score was only obtained in patients with Child B cirrhosis (P: 0.033). When the oral replacement therapies were investigated separately, a statistically significant decrease in MELD scores was detected with product 1 (P: 0.043). Conclusion: Prealbumin can be used as an easily measured parameter for earlier detection of malnutrition in patients with cirrhosis and without clinically apparent malnutrition. Oral nutritional support, especially with products containing relatively high carbohydrate levels and low protein, may have a favorable effect on MELD scores.
