Yazar "Kendirci, M" seçeneğine göre listele

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    Exploring resveratrol-enriched collagen dressings for diabetic foot ulcers: A retrospective study of wound healing outcomes
    (ELSEVIER SCI LTD, 2025) Sezikli, I; Kendirci, M
    Background: Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes mellitus, often leading to prolonged hospitalization, high treatment costs, and potential amputations. Despite advances in wound care, current dressing materials often lack bioactive properties to modulate chronic wound environments. Aim: To evaluate the clinical efficacy of resveratrol-enriched collagen dressings compared to standard collagen dressings in the management of Wagner grade 2 diabetic foot ulcers. Methods: This retrospective study included 41 patients with Wagner grade 2 DFUs treated at a diabetic foot clinic. Nineteen patients received resveratrol-enriched collagen dressings, while 22 received standard collagen dressings. Patients were matched based on age, glycemic control (HbA1c), and arterial supply (ABPI). Primary and secondary outcomes included wound size reduction, hospitalization duration, and dressing frequency. Statistical analyses included Student's t-test, Mann-Whitney U test, and Kaplan-Meier survival analysis. Results: The resveratrol group demonstrated significantly greater wound size reduction (49.2 % f 9.1 vs. 32.8 % f 8.5; p = 0.021), shorter hospital stay (12.3 f 2.8 vs. 14.5 f 3.2 days; p = 0.045), and fewer dressing changes (19.8 f 5.2 vs. 24.3 f 6.7; p = 0.038). No adverse events were reported. Improved outcomes were attributed to resveratrol's antioxidant, anti-inflammatory, and antimicrobial effects. Conclusions: Resveratrol-enriched collagen dressings significantly improved clinical outcomes in DFUs, suggesting a promising adjunctive treatment strategy. Further prospective studies are warranted to confirm these findings and explore long-term benefits.
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    Negative pressure wound therapy in high-risk gastrointestinal surgery: a retrospective cohort study on postoperative complications
    (BMC, 2025) Sezikli, I; Topçu, R; Kendirci, M
    BackgroundSurgical site infections (SSIs) are a significant cause of morbidity in colorectal surgeries, mainly due to the contaminated nature of these procedures. Traditional wound management techniques have limitations, leading to prolonged hospital stays and increased healthcare costs. Negative pressure wound therapy (NPWT) has emerged as an advanced method for managing surgical wounds, promoting faster healing by enhancing tissue perfusion, reducing edema, and managing wound exudate. This retrospective cohort study aims to compare the outcomes of NPWT with those of conventional wound care in patients undergoing high-risk gastrointestinal surgeries.MethodsA total of 141 patients classified as having contaminated or dirty wounds were divided into two groups: the NPWT group (47 patients) and the conventional wound care group (94 patients). Postoperative outcomes, including SSIs, wound healing, dehiscence, and incisional hernia development, were monitored at 1 month and 1 year.ResultsThe results revealed a significant reduction in superficial SSIs in the NPWT group (6.4% vs. 18.1%, p = 0.04), along with shorter hospital stays (8.9 vs. 11.2 days, p = 0.01). Incisional hernia rates were also significantly lower in the NPWT group at both 1 month (6.4% vs. 12.8%, p = 0.05) and 1 year (6.4% vs. 16.0%, p = 0.03). While the reduction in deep SSIs did not reach statistical significance (2.1% vs. 9.6%, p = 0.08), the observed trend suggests further investigation.ConclusionThis study demonstrated that NPWT not only reduces the incidence of SSIs and hospital stays but also decreases the long-term incidence of incisional hernias. These findings suggest that NPWT should be considered a standard approach for managing high-risk surgical wounds, especially in gastrointestinal procedures, where infection risks are inherently greater.
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    The Impact of Aortic Calcification on Surgical Outcomes in Colorectal Cancer Patients: A Retrospective Analysis Focused on Anastomotic Leakage
    (MDPI, 2025) Turhan, VB; Karacif, O; Tutan, MB; Kartal, B; Şahin, F; Kendirci, M; Alkurt, EG
    Background and Objectives: Anastomotic leakage (AL) is a major complication of colorectal surgery (CRS), increasing morbidity, mortality, and healthcare costs. While several AL risk factors have been identified, the role of aortic calcification (AC) remains unclear. As a marker of systemic atherosclerosis, AC may impair tissue perfusion and anastomotic healing. Additionally, tumor factors (TNM stage, histology, and localization) and patient comorbidities (hypertension, cardiovascular disease, and neoadjuvant therapy) may contribute to AL risk. This study evaluates the association between preoperative AC and AL incidence while considering additional risk factors. Materials and Methods: This retrospective cohort study included 151 patients undergoing CRS from January 2020 to October 2023. Preoperative CT scans classified AC into Stage 0 (none), Stage 1 (<50%), and Stage 2 (>50%) of the aortic circumference. Data on demographics, tumor characteristics, neoadjuvant therapy, and comorbidities were collected. AL risk factors were analyzed using univariate and multivariate logistic regression. Results: AL occurred in 5.96% (9/151) of patients. AL incidence was significantly higher in patients with >50% AC (44.47% vs. 11.27%, p = 0.012). Multivariate analysis confirmed AC as an independent AL predictor (OR = 10.38, 95% CI: 1.243-92.118, p = 0.032). Rectal tumor localization (p = 0.038), hypertension (p = 0.027), cardiovascular disease (p = 0.014), and neoadjuvant therapy (p = 0.045) were also associated with increased AL risk. Conclusions: Severe AC is an independent predictor of AL in CRS. Additionally, rectal tumors, hypertension, cardiovascular disease, and neoadjuvant therapy contribute to AL risk. Preoperative vascular assessments and comprehensive risk stratification models may help identify high-risk patients and guide perioperative management strategies to reduce AL incidence.