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    Does small prostate predict high grade prostate cancer?
    (College of Physicians and Surgeons Pakistan, 2017) Çalışkan, Selahattin; Kaba, Selçuk; Koca, Orhan; İshak Öztürk, M.
    Objective: The current is study aimed to assess the patients who underwent radical prostatectomy for prostate cancer and investigate the association between prostate size and adverse outcomes at final pathology. Study Design: Comparative, descriptive study. Place and Duration of Study: Haydarpasa Numune Training and Research Hospital, Turkey, from January 2008 to January 2016. Methodology: The patients treated with open radical prostatectomy for prostate cancer were reviewed. Patient characteristics including prostate specific antigen (PSA), free PSA levels, age, biopsy, and radical prostatectomy results were recorded. The patients whose data were complete or prostate weight was equal to or less than 80 gm, were included in the study. Patients with < 40 gm prostate weight was in group 1 and the patients in group 2 had a prostate weight from 40 to 80 gm. High grade prostate cancer was defined to have a Gleason score between 7 or higher at biopsy and final pathology. Pathology and biopsy results were compared within groups. MedCalc Statistical Software demo version was used for statistical analyses. Results: There were 162 patients in this study. Of these, 71 (43.82%) patients were in group 1 and 91 (56.17%) patients were in group 2. The age ranged from 49 to 76 years. Mean value of 62.70 ±6.82 and 65.82 ±5.66 years in group 1 and 2, respectively. Fifty (70.42%) and 68 patients (74.74%) had a Gleason score of 6 in group 1 and 2, respectively. Organconfined disease was reported in 53 patients (74.64%) in group 1 and in 78 patients (85.71%) in group 2. Gleason score concordance between biopsy and prostatectomy was reported in 61 patients (67.03%) and downgrading was detected in 4 patients (4.4%) in group 2. The median tumor volume of the patients was 4.47 cm3 in group 1 and 6 cm3 in group 2 (p=0.502). High grade prostate cancer was reported in 52.11% and 45.05% of the patients in groups 1 and 2, respectively at final pathology (p=0.373). Conclusion: The present study demonstrated that smaller prostates are more likely to compose higher percentage of the high grade prostate cancer, local advanced disease, and the Gleason upgrading. The positive surgical margin rate is higher in patients with small prostates when it is compared with the other patients.
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    The renal neoplastic lesions in non-functioning kidney patients who underwent simple nephrectomy
    (2018) Çalışkan, Selahattin; Sungur, Mustafa; Özsoy, Emrah; Koca, Orhan
    The simple nephrectomy is usually performed in daily urology practice for the non-functioning kidney. The aim of this study is to determine the incidental malignancy rate of the patients who underwent nephrectomy procedure. In total, 258 patients were included in the study. The patients who underwent simple nephrectomy and diagnosed as renal tumor between January 2003 and March 2016 for the non-functioning kidney at our department were recorded. There were 258 patients in this study. Of these patients;123 were male and 134 were female patients. The mean age of the patients’ was 52.33+17.63 years. The presence of stone formation was detected in 92 patients (35.65%). The renal malignancy was reported in 9 patients.Among the patients with malignancy; 2 patients were female and 7 patients were male. The mean age of the patients was 54.77+8.81 years. The pathological examination revealed that 6 patients were transitional cell carcinoma (TCC) of the renal pelvis, 2 patients were renal cell carcinoma, one patient was cystic nephroma. Interestingly, nephrolithiasis was detected only in one patient. The prevalence of all malignancy and the malignant tumor was 3.48% and 3.10% in this study. The final pathology showed that there is a risk of malignancy fort he patients with the non-functioning kidney. The clinicians should be aware that the patient may be diagnosed as renal tumor after pathological examination.