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    A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model
    (Springer Verlag, 2016) Öz, Murat; Çetinkaya, Nilüfer; Baş, Sevda; Korkmaz, Elmas; Özgü, Emre; Terzioğlu, Serdar Gökay; Büyükkağnıcı, Ümran; Akbay, Serap; Çaydere, Muzaffer; Güngör, Tayfun
    Purpose: Platelet-rich plasma (PRP) has been known to possess an efficacy in tissue regeneration. The aim of this study was to determine the role of PRP on post-operative adhesion formation in an experimental rat study. Methods: Thirty Sprague-Dawley rats were randomly divided into control, hyaluronic acid, and PRP treatment groups and operated on for uterine horn adhesion modeling. Blood was collected to produce a PRP with platelet counts of 688 × 10 3 /?L, and 1 ml of either hyaluronic acid gel or PRP was administered over the standard lesions, while the control group received no medication. The evaluation of post-operative adhesions was done on the 30th post-operative day. The location, extent, type, and tenacity of adhesions as well as total adhesion scores, tissue inflammation, fibrosis and transforming growth factor-1beta (TGF-1?) expressions were evaluated. Results: The total adhesion score was significantly lower in the PRP group (3.2 ± 1.5) compared with the hyaluronic acid (5.0 ± 1.3) and control (8.1 ± 1.7) groups. The extent of the adhesions was significantly lower in the PRP group. There was no significant difference in the type and tenacity of adhesions between the hyaluronic acid and the PRP group. The level of inflammation was significantly higher in the control group than the others, while there was no difference between the PRP and hyaluronic acid groups. TGF-1? expression was significantly lesser in the PRP group than the control and hyaluronic acid groups. Conclusions: PRP is more effective than hyaluronic acid treatment in preventing post-operative adhesion formation in an experimental rat uterine horn adhesion model. © 2016, Springer-Verlag Berlin Heidelberg.
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    Awareness and Knowledge Levels of Turkish Collage Students About Human Papilloma Virus Infection and Vaccine Acceptance
    (Lippincott Williams & Wilkins, 2016) Öz, Murat; Çetinkaya, Nilüfer; Apaydın, Ayşen; Korkmaz, Elmas; Baş, Sevda; Özkara, Emre; Güngör, Tayfun
    [Abstract Not Available]
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    Awareness and knowledge levels of Turkish college students about human papilloma virus infection and vaccine acceptance
    (Springer New York LLC, 2018) Öz, Murat; Çetinkaya, Nilüfer; Apaydın, Ayşen; Korkmaz, Elmas; Baş, Sevda; Özgü, Emre; Güngör, Tayfun
    Awareness of HPV by the target population is an important determinant of vaccine acceptance. The aim of this study is to evaluate the awareness of HPV infection and acceptability of the HPV vaccines among Turkish college students. College students aged 18–30 who were attending a large public university in Ankara participated in this study. The participants were asked to complete a questionnaire to elicit demographic characteristics, awareness level of HPV and HPV vaccine, and willingness to be vaccinated. One thousand one hundred sixty students responded to the invitation email and completed the questionnaire. The mean scores of female students about HPV and HPV vaccine were 7.1/15 and 3.6/9, respectively, while these scores were 7.9/15 and 3.4/9 among male students, respectively. While 51 % percent of female and 33.5 % of male students had heard of HPV and 32.8 % and 18 % of them had heard of HPV vaccine, respectively, only 1.5 % of female and 0.4 % of male students had been vaccinated against HPV. A total of 507 students (43.7 %) had previously heard of HPV. Only 309 (26.6 %) of the participants had previously heard of the HPV vaccine, and 45.1 % of the students were willing to receive HPV vaccination. The main predictors for willingness to be vaccinated were the following: sexual experience, sexual behavior, past history of sexually transmitted infection (STI), and knowledge about HPV and HPV vaccine. Higher awareness levels of HPV and HPV vaccine are significantly related to greater willingness to be vaccinated, and the main reasons for rejecting the vaccine were insufficient information about the vaccine and possible unknown side effects. © 2016, American Association for Cancer Education.
  • Küçük Resim
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    Lympho-vascular space invasion indicates advanced disease for uterine papillary serous tumors arising from polyps
    (Asian Pacific Organization for Cancer Prevention, 2015) Selçuk, İlker; Korkmaz, Elmas; Özgü, Emre; Mengü, Türker; Erkaya, Salim; Güngör, Tayfun
    Background: Uterine papillary serous tumors are rarely seen and behave aggressively. Our aim was to evaluate uterine papillary serous tumors arising from polyps. Materials and Methods: Clinicopathological data of patients with uterine serous cancer arising from a polyp at the Gynecological Oncology Department of Zekai Tahir Burak Women's Health Education and Research Hospital were reviewed retrospectively. Results: We analyzed patients according to FIGO 2009 staging system as stage 1A and higher than stage 1A (3 and 6, respectively). All the patients were postmenopausal. Mean CA-125, CA-19.9 and CA15.3 levels were elevated in higher than stage 1A group. However we did not find a statistical difference between age, parity, polyp size, CA-125, CA-15.3, CA-19.9 and CEA levels. Lympho-vascular space invasion (LVSI) showed predictivity for advanced disease (p=0.025). Conclusions: The histopathologic nature of uterine serous carcinoma is a unique entity. LVSI is a prognosticator for defining an advanced stage uterine papillary tumor.
  • Küçük Resim
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    Optimal cone size to predict positive surgical margins after cold knife conization (CKC) and the risk factors for residual disease
    (Turkish-German Gynecological Education and Research Foundation, 2016) Öz, Murat; Çetinkaya, Nilüfer; Korkmaz, Elmas; Seçkin, Kerem Doğa; Meydanlı, Mehmet Mutlu; Güngör, Tayfun
    Objective: To determine the optimal cone size to achieve a reliable sensitivity and specificity for clear surgical margins after cold knife conization (CKC). Material and Methods: The medical reports of patients who had high-grade cervical intraepithelial lesions, carcinoma in situ, or stage 1A1 microinvasive carcinoma in their CKC specimens between June 2008 and January 2015 were reviewed retrospectively. Results: In total, 315 women fulfilled the inclusion criteria. The mean age of the patients was 40.7 years. The conization results were microinvasive carcinoma and high-grade squamous lesion (HSIL) for 8 and 307 patients, respectively. Ninety-nine patients had positive surgical margins. Eighty-one patients with positive cone margins underwent the repeat excisional procedure and 35 of them showed residual disease. In the univariate analyses, the patient age, menopausal status, and mean cone height parameters showed statistically significant differences between the patients with positive and negative margins. Also, residual disease was associated with the menopausal status and age of the patients. Conclusion: There is no optimal cone depth that is applicable for all patients. The most important predictors for positive margins are the menopausal status of the patient and that more than two quadrants are involved. However, the menopausal status and age of the patients were still predictors for residual disease. © 2016 by the Turkish-German Gynecological Education and Research Foundation.
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    Recurrent ‘growing teratoma syndrome’ in an adolescent girl with a history of ovarian immature teratoma: A case report*
    (Taylor and Francis Ltd, 2016) Yakut, Halil İbrahim; Korkmaz, Elmas; Çetinkaya, Nilüfer; Başer, Eralp; Irkkan, Çiğdem; Güngör, Tayfun
    The incidence of ovarian tumours in girls has been estimated as 2.6/100,000 cases annually, and malignant ovarian tumours coincide in about 1% of all childhood cancers. (Al Jama et al. 2011).About 70% of ovarian tumours derive from germ cells during adolescence, and approximately, one-third of them have malignant potential (Low et al.2012). The most common type of benign germ cell tumour is mature cystic teratoma, also called dermoid cyst, and the most common type of malignant germ cell tumour is dysgerminoma.
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    Response to the Letter to the Editor—Re: A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model
    (Springer Verlag, 2016) Öz, Murat; Çetinkaya, Nilüfer; Baş, Sevda; Korkmaz, Elmas; Özgü, Emre; Terzioğlu, Serdar Gökay; Büyükkağnıcı, Ümran; Akbay, Serap; Çaydere, Muzaffer; Güngör, Tayfun
    Thank you for your interest in our experimental study entitled “A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model” [1]. We read your comments on the article with great interest.
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    The possibly reversible isotretinoin effect of decreased ovarian reserve in sprague-dawley albinos: part I, biochemical analyses
    (S. Karger AG, 2017) Korkmaz, Elmas; Çetinkaya, Nilüfer; Öz, Murat; Özgü, Emre; Baş, Sevda; Işıkalan, Mehmet; Büyükkağnıcı, Ümran; Çaydere, Muzaffer; Hücümenoğlu, Sema; Güngör, Tayfun
    Background: The study aims to determine the detrimental effects of 7.5 mg/kg/day isotretinoin treatment on the anti-Mullerian hormone (AMH) levels in an experimental study to see whether the effects on ovarian reserve are reversible. Methods: Blood was sampled in 16 Sprague-Dawley albinos before any treatment to see baseline AMH levels. Then, the rats were randomly divided into 2 groups. Control group received only 1.0 ml soybean oil per oral for 30 days, whereas the study group received 7.5 mg/kg/day isotretinoin suspended in soybean oil. AMH levels were measured at the 30th day - immediately after the last medication - and on 60th day - 1 month after the last medication. Results: The mean values of AMH levels were 8.16 ± 1.47, 6.95 ± 1.87, 6.27 ± 0.71 and 8.20 ± 1.48, 6.56 ± 1.45, 7.07 ± 0.96 ng/ml before, immediately after and 1 month after the last medication in the control and isotretinoin treatment group, respectively. The mean AMH levels significantly decreased (p = 0.02) immediately after isotretinoin administration. The mean AMH levels 1 month after the last dose of isotretinoin therapy were higher than the levels immediately after the medication; however, the difference was not statistically significant. Conclusion: This study indicates that exposure to isotretinoin is responsible for decreased AMH levels in experimental rat model and this effect seems to be reversible. © 2016S. Karger AG, Basel. Copyright: All rights reserved.