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Öğe Karagül ve Norduz koyunlarında bazı hematolojik ve biyokimyasal parametreler(Van Yüzüncü Yıl Üniversitesi Veteriner Fakültesi, 2017-10-24) Comba, Bahat; Mert, Handan; Comba, Arzu; Mis, Leyla; Mert, NihatBu çalışma da aynı yaş, bakım ve besleme şartlarında sağlıklı Karagül ve Norduz koyun ırklarının bazı hematolojik ve biyokimyasal parametrelerinin karşılaştırılması amaçlandı. Her bir koyun ırkından 15 adet olmak üzere toplam 30 hayvan çalışmaya dahil edildi. Tam kan alyuvar sayısı (RBC), hemoglobin (HGB), hematokrit (HCT), ortalama alyuvar hacmi (MCV), ortalama alyuvar hemoglobini (MCH), ortalama alyuvar hemoglobin konsantrasyonu (MCHC), alyuvarların dağılım sıklığı (RDWC), akyuvar (WBC), lenfosit (LYM), monosit (MON), granülosit (GRN) sayıları, lenfosit (LY), monosit (MO), granülosit (GR) yüzdeleri, trombosit sayısı (PLT), trombosit yüzdesi (PCT), ortalama trombosit hacmi (MPV), trombosit dağılım sıklığı (PDWC) gibi hematolojik parametreleri kan sayım cihazında; serum alkalen fosfataz (ALP), aspartat aminotransferaz (AST), alkali fosfataz (ALP), gamma-glutamil transpeptidaz (GGT), total protein (TP) albümin (A), globulin (G) total bilirubin (TB) indirekt bilirubin (İB), kreatin, kreatin kinaz (CK), kreatin kinaz MB (CK-MB), üre, ürik asit (UA), kan üre azotu (BUN) ve amilaz biyokimyasal parametreleri oto analizörde belirlendi. HCT (p<0.001), MCV (p<0.001) ve MCH (p<0.001), CK (p<0.05) ve amilaz (p<0.001) Karagül koyun ırkında; LYM (p<0.05), RDWC (p<0.001), PLT (p<0.001), PCT (p<0.001), TP (p<0.05) ve IB (p<0.001) ise Norduz koyun ırkında daha yüksekti. Diğer parametrelerdeki değişimler önemsizdi. Sonuç olarak, Karagül ve Norduz koyun ırklarına ait bazı hematolojik ve biyokimyasal parametrelerdeki farklılıklar ırklara ait bir özellik olabilir. Elde edilen verilerin özellikle Veteriner Hekimlere, bu koyun ırklarına ait hastalıkların erken tanısında ve tedavisinde, prognozunda ve de bu ırklar ile ilgili yapılacak araştırmalarda referans olabileceği kanısındayız.Öğe Retinol, ?-tocopherol and vitamin D3 in White Muscle disease(Medycyna Weterynaryjna, 2018-01-26) Mert, Handan; Yıldırım, Serkan; Yörük, İbrahim Hakkı; Irak, Kıvanç; Comba, Bahat; Mert, Nihat; Aysin, Nesrullah; Comba, ArzuVitamins are essential for the health of all living organisms. Vitamins E, A, D and K are known as fat-soluble vitamins, and deprivation of vitamin E causes various disorders, especially in the reproduction and cardiovascular systems and in muscle functions. Vitamin A, on the other hand, has roles in various biological functions – like eyesight – and the growth, reproduction and differentiation of epithelial cells. Vitamin A deficiency leads to the keratinization of the epithelium, and disorders related to the metaplasies of the genital and genitourinary systems. Conversely, vitamin D is defined as a pro-hormone and is responsible for Cahomeostasis, and thus indirectly affects the bone metabolism, bone structure, and cellular and neural functions of Ca. White muscle disease (WMD) can occur in newborn lambs, but is more commonly seen in lambs of up to 3 months of age. In this study, 30 lambs of 3 to 50-days-old from different flocks diagnosed with White Muscle Disease (WMD) were selected as research material, while the control group consisted of 8 healthy lambs. With the aim of clarifying the cause of WMD, serum fat-soluble vitamins, retinol, ?-tocopherol and vitamin D3 levels were determined in 16 lambs. Gluteal and heart musclet issue samples also were taken from 30 lambs with WMD. The vitamin levels of the samples were analysed by HPLC. The levels of serum ?-tocopherol, retinols, and vitamin D3 were foundto be low in the diseased animals, but only retinol (p<0.001) and ?-tocopherol (p<0.0011) level differences were statistically relevant. Macroscopically, Zenker’s necrosis was determined in the heart muscles of 17 lambs, and in the gluteal and chest muscles of 6 lambs. 7 lambs displayed necrosis in both their heart and in gluteal muscles. The samples were analyzed microscopically to reach similar findings: swollen homogeneous pink muscles, pycnotic nuclei, and hyperaemic and haemorrhagic blood vessels in gluteal, chest and heart muscles. Hyaline degeneration and Zenker's necrosis, dystrophic regions in necrotic areas, cc was detected as a severe disease in lambs at an early stage of life with advanced degeneration in different muscle tissues. Deficiency of fat-soluble vitamins was also detected in the sick animals. Control group lambs had higher levels of ? tocopherol and retinol (p<0.001) compared to the sick lambsÖğe Retinol, alpha-tocopherol and vitamin D-3 in White Muscle Disease(Polish Soc Veterinary Sciences Editorial Office, 2018) Mert, Handan; Yildirim, Serkan; Yoruk, İbrahim Hakkı; Irak, Kıvanç; Comba, Bahat; Mert, Nihat; Comba, ArzuVitamins are essential for the health of all living organisms. Vitamins E, A, D and K are known as fatsoluble vitamins, and deprivation of vitamin E causes various disorders, especially in the reproduction and cardiovascular systems and in muscle functions. Vitamin A, on the other hand, has roles in various biological functions - like eyesight - and the growth, reproduction and differentiation of epithelial cells. Vitamin A deficiency leads to the keratinization of the epithelium, and disorders related to the metaplasies of the genital and genitourinary systems. Conversely, vitamin D is defined as a pro-hormone and is responsible for Cahomeostasis, and thus indirectly affects the bone metabolism, bone structure, and cellular and neural functions of Ca. White Muscle Disease (WMD) can occur in newborn lambs, but is more commonly seen in lambs of up to 3 months of age. In this study, 30 lambs of 3 to 50-days-old from different flocks diagnosed with White Muscle Disease (WMD) were selected as research material, while the control group consisted of 8 healthy lambs. With the aim of clarifying the cause of WMD, serum fat-soluble vitamins, retinol, alpha-tocopherol and vitamin D3 levels were determined in 16 lambs. Gluteal and heart musclet issue samples also were taken from 30 lambs with WMD. The vitamin levels of the samples were analysed by HPLC. The levels of serum alpha-tocopherol, retinols, and vitamin D3 were foundto be low in the diseased animals, but only retinol (p < 0.001) and alpha-tocopherol (p < 0.001) level differences were statistically relevant. Macroscopically, Zenker's necrosis was determined in the heart muscles of 17 lambs, and in the gluteal and chest muscles of 6 lambs. 7 lambs displayed necrosis in both their heart and in gluteal muscles. The samples were analyzed microscopically to reach similar findings: swollen homogeneous pink muscles, pycnotic nuclei, and hyperaemic and haemorrhagic blood vessels in gluteal, chest and heart muscles. Hyaline degeneration and Zenker's necrosis, dystrophic regions in necrotic areas, cc was detected as a severe disease in lambs at an early stage of life with advanced degeneration in different muscle tissues. Deficiency of fat-soluble vitamins was also detected in the sick animals. Control group lambs had higher levels of alpha-tocopherol and retinol (p < 0.001) compared to the sick lambs.Öğe Some mineral substance, oxidative stress and total antioxidant levels in Norduz and Morkaraman sheep(Van Yüzüncü Yıl Üniversitesi Veteriner Fakültesi, 2018-10-09) Mis, Leyla; Mert, Handan; Comba, Arzu; Comba, Bahat; Doğan Söğütlü, İnci; Irak, Kıvanç; Mert, NihatThe aim of the study was to compare some mineral substances and total antioxidant and totaloxidan levels of healthy Morkaraman and Norduz sheep breeds in the same age and care conditions. A total of 20 animals, 10 from each sheep breed, were included in the study. Serum total oxidant status (TOS) and total antioxidant status (TAS) were determined by a colorimetric method. OSI value was determined by calculating the TASTOS ratio. When the two sheep were compared, there was a difference between TAS, Mg, P levels. Antioxidant levels of Norduz sheep were higher than morkaraman sheep. The given data may be the reference value for studies of these sheep breedsÖğe The Effect of Cinnamaldehyde on The Activity of Glucose-6-Phosphate Dehydrogenase, Some Biochemical And Hematological Parameters in Diabetic Rats(Wiley, 2017) Celik, Remzi; Mert, Handan; Comba, Bahat; Mert, Nihat[Abstract Not Available]
