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Öğe Behçet disease with vascular involvement: Effects of different therapeutic regimens on the incidence of new relapses(Lippincott Williams and Wilkins, 2015) Alibaz Öner, Fatma; Karadeniz, Aslı; Yılmaz, Sema; Balkarlı, Ayşe; Kimyon, Gezmiş; Yazıcı, Ayten; Çınar, Muhammet; Yılmaz, Sedat; Yıldız, Fatih; Bilge, Şule; Bilgin, Emre; Coşkun, Belkıs; Omma, Ahmet; Çetin, Gözde; Çağatay, Yonca; Karaaslan, Yaşar; Sayarlıoğlu, Mehmet; Pehlivan, Yavuz; Kalyoncu, Umut; Karadağ, Ömer; Kaşifoğlu, Timuçin; Erken, Eren; Pay, Salih; Çefle, Ayşe; Kısacık, Bünyamin; Onat, Ahmet; Çobankara, Veli; Direşkeneli, HanerVascular involvement is one of the major causes of mortality and morbidity in Behcet disease (BD). There are no controlled studies for the management of vascular BD (VBD), and according to the EULAR recommendations, only immunosuppressive (IS) agents are recommended. In this study, we aimed to investigate the therapeutic approaches chosen by Turkish physicians during the initial event and relapses of VBD and the association of different treatment options with the relapses retrospectively. Patients with BD (n-936, female/male: 347/589, mean age: 37.6 ± 10.8) classified according to ISG criteria from 15 rheumatology centers in Turkey were included. The demographic data, clinical characteristics of the first vascular event and relapses, treatment protocols, and data about complications were acquired. VBD was observed in 27.7% (n - 260) of the patients during followup. In 57.3% of the VBD patients, vascular involvement was the presenting sign of the disease. After the first vascular event, ISs were given to 88.8% and AC treatment to 59.8% of the patients. Median duration of AC treatment was 13 months (1-204) and ISs, 22 months (1-204). Minor hemorrhage related to AC treatment was observed in 7 (4.7%) patients. Asecond vascular event developed in 32.9% (n=86) of the patients. The vascular relapse rate was similar between patients taking only ISs and AC plus IS treatments after the first vascular event (29.1% vs 22.4%, P=0.28) and was significantly higher in group taking only ACs than taking only ISs (91.6% vs 29.1%, P<0.001). During follow-up, a third vascular event developed in 17 (n = 6.5%) patients. The relapse rate was also similar between the patients taking only ISs and AC plus IS treatments after second vascular event (25.3% vs 20.8%, P=0.93). When multivariate analysis was performed, development of vascular relapse negatively correlated with only IS treatments. We did not find any additional positive effect of AC treatment used in combination with ISs in the course of vascular involvement in patients with BD. Severe complications related to AC treatment were also not detected. Our results suggest that short duration of IS treatments and compliance issues of treatment are the major problems in VBD associated with vascular relapses during follow-up. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.Öğe Correlation of RAPID3 (Routine Assessment of Patients Index Data 3), DAS28 (Disease Activity Score 28) and CDAI (Clinical Disease Activity Index) in Disease Activity and Effects of Education Level and Co-Morbid Diseases on this Assessment in RA(Clinical & Exper Rheumatology, 2014) Sahin, Kubilay; Karaaslan, Yasar; Ozbalkan, Zeynep; Omma, Ahmet; Yesil, Nesibe[Abstract Not Available]Öğe Correlation of RAPID3, DAS28 and CDAI in Disease Activity and Effects of Education Level and Co-Morbid Diseases on This Assesment in RA.(Wiley-Blackwell, 2014) Sahin, Kubilay; Karaaslan, Yasar; Ozbalkan, Zeynep; Omma, Ahmet; Yesil, Nesibe[Abstract Not Available]Öğe The prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with thyroid autoimmunity(MEDİTAGEM Ltd. Şti., 2016) Omma, Ahmet; Can Sandıkçı, Sevinç; Omma, Tülay; Karaaslan, YaşarAmaç: Anti-CCP antikorları romatoid artritin (RA) tanı koydurucu belirteçlerinden bir tanesi olmakla birlikte sistemik lupus eritematozus (SLE), primer Sjögren sendromu (pSS) gibi diğer hastalıklarda da saptanabilmektedir. Yetişkinlerde tiroid otoimmünitesi (TO) ve anti-CCP pozitifliğiyle ilgili günümüze kadar herhangi bir veri yayınlanmamıştır. Biz bu çalışmada yetişkin TO olan hastalarda anti-CCP pozitifliği yaygınlığını saptamayı amaçladık. Yöntem ve Gereçler: Ocak 2010-Ekim 2014 tarihleri arasında anti-CCP, RF ve anti-tiroid peroksidoz (anti-TPO) ve/veya TSH reseptör antikoru (TRAb) istenen 1282 hastanın kayıtları tıbbi kayıt sisteminden retrospektif olarak incelendi. TO, tanısı tiroid otoantikorlarının normal değerlerinin üst sınırının üzerinde saptanması ile kondu. RF ve anti-CCP pozitifliği değerler normal aralığın üzerinde olduğu zaman düşünüldü. Bulgular: TO olan grupta,TPO-Ab, TRAb, CCP ve RF pozitifliği sırasıyla 332 (%99), 7 (%2), 44 (%13), ve 78 (%23) olarak saptandı. TO olmayan grupta 70 kişide Anti-CCP pozitifliği (%7.4) ve 378 kişide RF pozitifliği (%20) saptandı. Anti-CCP pozitiflik oranı TO olan grupta TO olmayan gruba göre anlamlı olarak daha yüksek saptandı (%13 vs.%7.4, p<0.001). Ancak RF pozitifliği yönünden gruplar arasında anlamlı olarak fark yoktu. Sonuç: Bizim çalışmamız TO olan hastalarda anti-CCP prevalansının arttığını göstermiştir. Bu da bize Anti-CCP antikorlarının RA'ya ek olarak TO olanlarda da görülebileceğini düşündürür.Öğe The Prevalence of Geriatric Syndromes in Patients with Rheumatoid Arthritis and Relationship between Disease Activity(Clinical & Exper Rheumatology, 2014) Yesil, Nesibe Karahan; Ates, Askin; Sahin, Kubilay; Omma, Ahmet; Yesil, Yusuf; Aslar, Zeynep Ozbalkan; Karaaslan, Yasar[Abstract Not Available]
