Yazar "Ozsoy, Filiz" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Estrogen Receptor 1 Gene rs22346939 and rs9340799 Variants are Associated with Major Depressive Disorder and its Clinical Features
    (Bentham Science Publ Ltd, 2021) Ozsoy, Filiz; Nursal, Ayse F.; Karakus, Nevin; Demir, Meral O.; Yigit, Serbulent
    Objective: Major Depressive Disorder (MDD) is a major health problem worldwide. Estrogen interacts with the central nervous system and has been shown to affect anxiety and depressive behavior. Estrogen mediates its effects by connecting its receptors, estrogen receptors 1 and 2. The purpose of this case-control study was to clarify the association between MDD risk and estrogen receptor 1 (ESR1) gene variants. Methods: This study included 245 individuals (125 MDD patients and 120 healthy controls). Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) technics were used for genotypingESR1XbaII (rs9340799) and PvuII (rs22346939) variants. Results: There were statistically significant differences between the groups in terms of genotype frequencies of the ESR1PvuII (-397 T > C) variant (p = 0.049) but not for the XbaII (-351 A > G) variant (p > 0.05). However, a correlation was observed between MDD and ESR1XbaII variant after male participants were excluded (p = 0.028). Also, the high pain score of MDD patients was associated with the ESR1PvuII variant, especially in female patients (p = 0.021). According to the results of combined genotype analysis, AA-TC combined genotype was correlated with a decreased risk in patients with MDD compared to controls (p = 0.016), while the combined genotype of GGCC was associated with increased risk in the patients with MDD compared to controls (p = 0.042). Conclusion: The two ESR1 variants were associated with MDD risk and its features in both individual and combined forms.
  • [ X ]
    Öğe
    The Impact of PER3 VNTR Polymorphism on the Development of Schizophrenia in a Turkish Population
    (Pleiades Publishing Inc, 2021) Ozsoy, Filiz; Yigit, Serbulent; Nursal, Ayse Feyda; Kulu, Muberra; Karakus, Nevin
    Introduction: Up to 80% of patients who suffer from schizophrenia have sleep impairments, which affect physical and mental health, as well as quality of life. Several tandem repeat polymorphisms (VNTRs) in the Period 3 (Per3) gene have been associated with heritable sleep and circadian variables. The purpose of this study is to investigate the relationship between the VNTR variant of the PER3 gene and genetic predisposition of schizophrenia in a Turkish population. Method: Blood samples were taken from 100 patients with schizophrenia, and from 100 normal controls who are age and sex-matched. PER3 genotyping was performed on DNA by polymerase chain reaction (PCR) using specific primers. Results: For the PER3 VNTR polymorphism, we found no significant differences in the genotype distribution and allele frequency, between the schizophrenia and control groups. No association was noted between clinical and demographical characteristics of schizophrenia patients and the PER3 VNTR genotype distribution. Conclusions: This is the first study investigating association of the PER3 VNTR polymorphism with schizophrenia in a Turkish population. In conclusion, the results of this study do not support an association between the PER3 VNTR polymorphism and risk of schizophrenia in a Turkish population.