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Öğe A Case of Childhood Type 1 Diabetes Mellitus Who Developed Granuloma Annulare(Karger, 2018) Oztekin, Aynure; Kendirci, Havva Nur Peltek; Guney, Guven[Abstract Not Available]Öğe Disturbed sleep quality and increased depression scores in alopecia areata patients(2020) Oztekin, Aynure; Oztekin, CoskunAlopecia areata (AA) is a chronic inflammatory disease that affects the hair follicle and sometimes the nails. Comorbidity between alopecia areata and psychiatric disorders is well known. The aim of this study is to evaluate the relationship between the clinical characteristics of AA and sleep quality and depression. This study included 52 patients above 18 years of age who admitted to the dermatology clinic and diagnosed as alopecia areata, and 51 healthy volunteers. Sociodemographic data form, Beck Depression Inventory (BDI), and the Pittsburgh Sleep Quality Index (PSQI) were filled by the patients. Information about the severity of AA, the duration of the disease, the treatments they received, and comorbid illnesses were also recorded. The median BDI total score of the AA patients was higher than that of the control group. In AA patients, PSQI total score and most of the subscale scores were significantly higher than those of the control group. No difference could be found in BDI or PSQI scores according to the presence or absence of poor prognostic criteria. The results of our study support the long-standing relationship between AA and psychiatric disorders and indicate that sleep quality is impaired in addition to the increase in depression level. In particular, a more careful assessment of female AA patients and patients with comorbid atopic dermatitis is important in order not to miss comorbid psychiatric problems.Öğe Does Rosacea, a localized skin disease, affect the choroidal thickness?(Wiley, 2021) Sahin, Tayfun; Oztekin, Aynure; Cevher, SelimIntroduction This study aims to compare the choroidal thickness (CT) of patients with rosacea with healthy individuals. Methods This study was conducted with 42 patients with Papulopustular Rosacea (PPR), 38 patients with Erythematotelangiectatic Rosacea (ETR), and gender and age-matched 37 healthy individuals in the control group. CT measurements were done using the spectral-domain optical coherence tomography. Results Choroidal thickness means were measured as 352 +/- 78 mu m, 331 +/- 67 mu m, and 346 +/- 83 mu m at the subfoveal region; 323 +/- 72.3 mu m, 303.5 +/- 68.4 mu m, and 314 +/- 80.3 mu m at 1000 mu m nasal; and 325.2 +/- 71 mu m, 304.4 +/- 52.2 mu m, and 309 +/- 67 mu m at 1000 mu m temporal in the PPR, ETR, and control groups, respectively (p > 0.05). Conclusion Although rosacea is a common chronic skin disease that could have systemic findings, CT is not affected by this disease.Öğe Dynamic thiol/disulfide homeostasis in serum of patients with generalized vitiligo(Inst Bioloska Istrazivanja Sinisa Stankovic, 2019) Pektas, Gokhan; Pektas, Suzan Demir; Oztekin, Aynure; Oztekin, Coskun; Neselioglu, Salim; Erel, Ozcan; Sadi, GokhanVitiligo is a multifactorial disorder commonly associated with hypo-/depigmentation in the skin and may influence both children and adults psychologically because of the notable leopard-skin-like appearance. This study was designed to investigate the thiol/disulfide homeostasis in patients with generalized vitiligo and to determine its relationship with some of the demographical characteristics. Seventy-six generalized vitiligo patients and 67 healthy individuals were included in the study. Blood serum native thiol, disulfide and total thiol concentrations, together with some hematological parameters, were determined. Results demonstrated that native and total thiol contents, and their ratios, were significantly lower in vitiligo patients. Disulfide/native thiol and disulfide/total thiol ratios were significantly higher in the patient group. Progressivity of the disease strongly regulated the thiol/disulfide homeostasis in such a way that active vitiligo patients had reduced native and total thiol levels but increased disulfide/native thiol and disulfide/total thiol ratios. Moreover, there was a statistically significant negative correlation between both duration of the vitiligo and native and total thiol contents. As these results clearly demonstrated that thiol/disulfide homeostasis was shifted toward disulfide formation in patients with generalized vitiligo, determining the dynamic nature of thiol/disulfide homeostasis can be used to monitor disease progression.Öğe The association of depression, loneliness and internet addiction levels in patients with acne vulgaris(Bmc, 2020) Oztekin, Coskun; Oztekin, AynureBackground Acne vulgaris is a very common skin disorder that has negative effects on the mood, self image and social relations of the patients. We want to evaluate the effects of acne vulgaris and its severity on depression, loneliness, internet addiction levels, and the quality of life of young adult females. Methods Two hundred three female acne vulgaris patients and 202 healthy controls who admitted to the dermatology clinic of a university hospital formed the study sample. Global Acne Grading System (GAGS) was used to assess the severity of acne. The Young Internet Addiction Scale-Short Form (YIAS-SF), The Acne Quality of Life Scale (AQLS), The University of California Los Angeles-Loneliness Scale (UCLA-LS), and The Beck Depression Inventory (BDI) were used to collect information about the patients. Results The median BDI and the mean UCLA-LS and YIAS-SF scores were higher in the Acne group than those in the control group. The correlations between acne severity and the 3 scales were not significant but the correlations between AQLS and BDI, UCLA-LS, and YIAS-SF were highly significant. In multiple regression analysis, age and the BDI score predicted the YIAS-SF score significantly. Conclusions Our findings support the previous findings that acne vulgaris patients are prone to depression and loneliness, and expand these findings to the vulnerability against internet addiction. Loneliness and depression should be assessed and, if found, targeted by psychological means to prevent internet addiction in acne vulgaris patients.Öğe Vitamin D Levels in Patients with Recurrent Herpes Labialis(Mary Ann Liebert, Inc, 2019) Oztekin, Aynure; Oztekin, CoskunRecurrent infections of herpes simplex virus in the orolabial area are known as recurrent herpes labialis (RHL). Vitamin D has been shown to have an important immunomodulatory role and to be associated with several infectious diseases. This hospital-based case-control study aimed at investigating the association between vitamin D and RHL by comparing vitamin D levels in individuals with and without RHL. Individuals who presented to the dermatology clinic at a state hospital due to RHL (n = 50) and matching control group of healthy volunteers (n = 51) were studied. Their vitamin D levels were measured, stratified based on clinical guidelines, and compared. The average serum vitamin D (25-hydroxyvitamin D) levels were 23.8 +/- 15.5 and 42.0 +/- 26.3 nM in the patient and control groups, with significant differences between their average serum vitamin D levels and vitamin D status. The studied population had serious vitamin D deficiency regardless of having RHL, with vitamin D levels below the adequate limits in more than 96% of the population. Most importantly, the study established a significant association between low serum vitamin D levels and the presence of RHL. Further interventional and pathophysiological studies should clarify the nature and mechanism of the relationship.
