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  • Küçük Resim
    Öğe
    Çölyak hastalığı tanısı alan çocuklarda kemik mineral yoğunluğu ve kemik metabolizması belirteçlerinin değerlendirilmesi
    (2020) Peltek Kendirci, Havva Nur; Kaba, İlknur; Comba, Atakan; Demir, Emre
    Amaç: Çölyak hastalığında kalsiyum ve D vitamini eksikliğine bağlı metabolik kemik hastalığı en sık ekstraintestinal semptomlardan biridir. Bu çalışmada, çölyak hastalığı olan çocuklarda tanı esnasında kemik mineral yoğunluğunun değerlendirilmesi ve kemik mineral metabolizmasıyla ilişkili faktörlerin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Çalışmaya hastanemiz çocuk gastroenteroloji bölümünde Aralık 2015-Aralık 2019 tarihleri arasında çölyak hastalığı tanısı alan 43 çocuk hasta alındı. Retrospektif olarak hastaların klinik, antropometrik, patolojik ve laboratuar özellikleri [kalsiyum, fosfor, alkalenfosfataz (ALP), parathormon (PTH), 25-OH vitamin D düzeyleri] incelendi. Tanıda Dual Energy X-Ray Absorptiometry (DEXA) yöntemi ile ölçülmüş olan lumbal (L1-L4) kemik mineral yoğunluğu düzeyleri değerlendirilerek kronolojik yaşa ve boy yaşına göre Z-skorları hesaplandı. Bulgular: Ortalama yaşları 9,9±4,8 (2,5-17,7) yıl olan 43 hastanın (34 kız/9 erkek) verileri değerlendirildi. %30,2’si (n=13) 0-6 yaş, %30,2’si (n=13) 7-11 yaş aralığında ve % 39,5’i (n=17) 11 yaş üzerindeydi. Yaşa göre KMY Z-skoru -0,83±1,1 (-3,6- 1,6), boy yaşına göre KMY Z-skoru -0,18±1,1 (-3,6-1,8) saptandı. Hastaların %51,2’sinde (n=22) yaşa göre KMY Z-skoru>-1, %34,9’unda (n=15) -1 ve -2 arasında ve %14’ünde (n=6) <-2 saptandı. Yaşa göre KMY Z-skorunun<-2 olma oranı 11 yaştan büyük çocuklarda anlamı olarak yüksekti (p<0,001). Hastaların KMY Z-skorları ile serum D vitamini, kalsiyum, fosfor, ALP ve PTH düzeyleri arasında ilişki saptanmadı (p>0,050). Sonuç: Çölyak hastalarında tanı yaşının gecikmesi kemik mineral yoğunluğunu olumsuz etkilemektedir. Erken yaşta tanı konulması kemik mineral kaybını engeller ve osteopeni/osteoporoz gelişmiş olan hastalarda tedavi olanağı sağlayarak morbiditeyi azaltır.
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    Öğe
    Evaluation of Bone Mineral Density and Bone Metabolism Markers in Hicldren Diagnosed as Celiac Disease
    (Karger, 2018) Peltek Kendirci, Havva Nur; Comba, Atakan; Demir, Emre
    [Abstract Not Available]
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    Öğe
    Evaluation of Cases with Pubertal Gynecomastia
    (Karger, 2018) Peltek Kendirci, Havva Nur; Demir, Emre
    [Abstract Not Available]
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    Öğe
    Evaluation of Relation Between Diabetic Education Levels of Type 1 DM Child/Adolescent and Parents and Metabolic Control
    (Karger, 2018) Peltek Kendirci, Havva Nur; Karayurt, Ümran; Demir, Emre
    [Abstract Not Available]
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    Öğe
    EVALUATION OF THE LIFE AND SLEEP QUALITY AND THE DETERMINATION OF THE RELATION WITH METABOLIC CONTROL IN CHILDREN AND ADOLESCENTS WITH TYPE-1 DIABETES MELLITUS
    (Karger, 2017) Peltek Kendirci, Havva Nur; Özakar Akça, Selen; Karayurt, Ümran
    [Abstract Not Available]
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    Öğe
    Investigating AXIN1 gene polymorphisms in Turkish children with cryptorchidism: A pilot study
    (ELSEVIER SCI LTD, 2024) Doğan, Gül; Yılmaz, Akın; İpek, Hülya; Metin, Mehmet; Peltek Kendirci, Havva Nur; Afşarlar, Çağatay Evrim
    Introduction Cryptorchidism is one of the most common congenital anomalies in male children, occurring in 2e5% of full-term male infants. Both genetic and environmental factors are observed to play a role in its etiology. A study conducted in Japan identified the AXIN1 gene as being associated with cryptorchidism. Objective We aimed to conduct a pilot study on AXIN1 gene polymorphism in Turkish children with cryptorchidism, and whether AXIN1 gene polymorphism is a risk factor for cryptorchidism. Study design Between January 2023 and December 2023, we have planned a prospective controlled study including 84 boys operated for cryptorchidism as study group, and 96 boys operated for circumcision as control group. The remaining blood samples of preoperative laboratory tests in ethylenediamine tetraacetic acid (EDTA) tubes were kept at 20 Co freezer for genomic studies. Patient demographics, physical examination and operative findings were recorded, study patients were grouped according to testis localization. After collecting all samples, genomic DNA isolation procedure was done, and analysis of the 3 polymorphisms (rs12921862, rs1805105 and rs370681) of AXIN1 gene was performed using conventional Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) method. Genotype and allele frequencies of each group was analyzed and compared. Results The most common location of cryptorchid testis was proximal inguinal (53%), followed by distal inguinal (25.3%), bilateral (13.3%), and intra-abdominal (8.4%). Regarding the 3 polymorphisms of AXIN1 gene, there was no significant difference between study and control groups, in terms of genotype and allele frequencies (P > 0.05). Eight haplotype blocks were estimated for 3 polymorphisms of AXIN1. However, no significant difference was observed between study and control groups regarding haplotype distributions (P > 0.05). In addition, the comparison of the localization of testis with AXIN1 gene polymorphism did not show any significant difference among cryptorchid testis groups (P > 0.05). Discussion The AXIN1 gene is located on chromosome 16p and its polymorphisms have been associated with various diseases. In a Chinese study, the rs370681 polymorphism was found to be associated with cryptorchidism. However, our results showed no association between the AXIN1 gene haplotypes for the studied polymorphisms and cryptorchidism. Conclusion In this study we have investigated the AXIN1 gene polymorphism in Turkish children with cryptorchidism as a pilot study. Although we could not identify any difference as compared to control group, further research is necessary to uncover the underlying molecular mechanisms contributing to the development of cryptorchidism.
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    Öğe
    Precocious Puberty and Role of Pediatric Nurse
    (2020) Özakar Akça, Selen; Turan, Ahu Pınar; Peltek Kendirci, Havva Nur
    Precocious puberty (PP) is the physical and hormonal manifestations of early pubertal development occurring at an earlier age than the normally accepted limit. With this pre?sent article it is aimed to increase the awareness of pediatric nurses about PP. In this literatüre review, the definition of PP pathophysiology, etiology, epidemiology, clinic, diagnosis, tre?atment, nursing initiatives and definitive diagnosis. The early onset of puberty can lead to early growth of the mammals, pre?mature menstruation, growth in the penis and testes in boys, early onset of sperm production and increased libido, due to early closure of the epiphyses in children and short stature in the adult years. Emotional stress or behavioral problems cause psychosocial problems due to incompatibility of physical, hor?monal and psychological development. Pediatric nurses have important responsibilities in the early diagnosis of PP children, in the orientation to appropriate centers, in the implementation of school-family cooperation as well as of the application of nursing approaches to the necessary precautions.
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    Öğe
    The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy
    (NLM (Medline), 2020) Muratoğlu Şahin, Nursel; Peltek Kendirci, Havva Nur; Çetinkaya, Semra; Savaş Erdeve, Şenay; Aycan, Zehra
    Background: Some studies have examined the effect of gonadal suppression on insulin-like growth factor-1 (IGF-1) levels and the growth velocity (GV) with conflicting results.Methods: Forty-four girls treated with gonadotropin-releasing hormone analogue (GnRHa) for central precocious puberty (CPP) were included in the study. IGF-1 levels were examined at the beginning and after 12 months of treatment.Results: IGF-1 and IGF-1 standard deviation score (SUS) according to chronological age (CA-IGF-1 SUS) at diagnosis were positively correlated with chronological age (CA), anthropometric measurements, stage of puberty, bone age (BA), BA-CA, follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol, uterus length, endometrium thickness and ovarian volume (OV) at diagnosis (p <0.05). There was no significant difference in IGF-1 levels after treatment. However, there was a negative correlation between Delta IGF-1 SDS and IGF-1 level, CA-IGF-1 SDS and BA-IGF-1 SDS at diagnosis (p <0.05). There was no correlation between GV and IGF-1, Delta IGF-1. GV was negatively correlated with basal LH level at diagnosis (p = 0.008, r=-0.397). Peak LH levels of the patients who had GV-SDS <0 were more suppressive than those of the patients who had GV-SDS> 0 after 12 months of treatment. Conclusions: It was determined that the IGF-1 level and CA-IGF-1 SDS at baseline were correlated with more advanced pubertal stage prior to treatment. Initiation of treatment with a relatively high level of IGF-1 increased the risk of a decrease in the IGF-1 level. Likewise, the initiation of treatment with a relatively high LH level may increase the risk of low GV, but low GV was not related to the IGF-1 level. Increased sex steroid suppression may increase the risk of low GV.