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    Convalescent plasma therapy and donor selection for COVID-19 outbreak: A help from survivors to patients
    (Lahore Medical & Dental Coll, 2020) Sahin, Havva Hande Keser; Eryilmaz, Fahri; Sahin, Mustafa
    The Coronavirus pandemic, which began in Wuhan-China in December 2019, was evaluated with WHO data. The effectiveness of convalescent plasma therapy in the pandemic was discussed in the present review. The importance of donor selection for this treatment method was emphasized. We offer the world that convalescent plasma therapy should be developed to combat the pandemic. But not all cases have closed, and new cases continue to be diagnosed around the world. The pandemic is very aggressive, and the world is under serious threat. No vaccine or antiviral agent effective on Coronavirus has yet been produced. Each country can combine survivor-induced convalescent plasma treatment into existing treatments until the Coronavirus vaccine and antiviral agent are produced. This method can offer a time-saving treatment option for every country with its advantages such as easy applicability, low cost and limited medical equipment requirements, but vaccine-drug researches should be accelerated internationally. We believe that target donor selection will determine success in convalescent plasma treatment. Multicenter international clinical trials are needed to combat the COVID-19 pandemic and to develop convalescent plasma therapy.
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    Preoperative evaluation of EDTA-dependent pseudothrombocytopenia before lumbar disc herniation surgery: A case report
    (2018) Şahin, Mustafa; Savcı, Ünsal; Sahin, Havva Hande Keser
    Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia (EDTA-PTCP) is an in vitro phenomenon characterized the clustering of platelets following the use of EDTA as an anticoagulant, leading to a decreased analyzer platelet count in a complete blood count (CBC). This report is a description of the case of a 47-year-old male patient admitted to a neurosurgery clinic with the complaints of back and leg pain. A neurological examination and lumbar magnetic resonance imaging revealing extruded disc herniations led to a decision to perform surgery. Thrombocytopenia was detected in the preoperative testing of the patient. The CBC was reanalyzed using citrate. Peripheral blood smears of the patient collected using citrate and EDTA were compared. Thrombocytopenia was not detected in a CBC of the citrated sample and the peripheral smear did not reveal platelet clusters. Pseudothrombocytopenia was considered, as the anamnesis, physical examination findings, and coagulation tests of the patient were not consistent with thrombocytopenia. In conclusion, EDTA-PTCP was diagnosed during the preoperative evaluation of the patient.