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Öğe Convalescent plasma therapy and donor selection for COVID-19 outbreak: A help from survivors to patients(Lahore Medical & Dental Coll, 2020) Sahin, Havva Hande Keser; Eryilmaz, Fahri; Sahin, MustafaThe Coronavirus pandemic, which began in Wuhan-China in December 2019, was evaluated with WHO data. The effectiveness of convalescent plasma therapy in the pandemic was discussed in the present review. The importance of donor selection for this treatment method was emphasized. We offer the world that convalescent plasma therapy should be developed to combat the pandemic. But not all cases have closed, and new cases continue to be diagnosed around the world. The pandemic is very aggressive, and the world is under serious threat. No vaccine or antiviral agent effective on Coronavirus has yet been produced. Each country can combine survivor-induced convalescent plasma treatment into existing treatments until the Coronavirus vaccine and antiviral agent are produced. This method can offer a time-saving treatment option for every country with its advantages such as easy applicability, low cost and limited medical equipment requirements, but vaccine-drug researches should be accelerated internationally. We believe that target donor selection will determine success in convalescent plasma treatment. Multicenter international clinical trials are needed to combat the COVID-19 pandemic and to develop convalescent plasma therapy.Öğe Coronavirus-19 outbreak in children: Different clinical status of disease in children and the effect of isolation on education and social life, globally(Wiley, 2021) Onganlar, Yasar Huseyin; Keser Sahin, Havva Hande; Sahin, Mustafa[Abstract Not Available]Öğe Effects of mesenchymal stem cell and amnion membrane transfer on prevention of pericardial adhesions(Walter De Gruyter Gmbh, 2020) Kabalci, Mehmet; Sahin, Mustafa; Pekcan, Zeynep; Zengin, Mehmet; Dogru, Mehmet Tolga; Kisa, UclerBackground: To investigate and compare the antiadhesive/antifibrotic effects of mesenchymal stem cells (MSC) and amnion membrane transfer (AMT) in a rat model. Material and methods: Three experimental and sham groups were formed using 30 Wistar-Albino rats. AMT and MSC were applied to the related groups. The control group was not treated. After 12 weeks follow-up, intracardiac blood and cardiac-pericardiac tissue samples were taken. The severity of adhesions and fibrosis were scored macroscopically and microscopically with Hematoxylin/ Eosin and Masson's trichrome staining. TNF-alpha, TGF-beta, IL-1, PDGF, FGF, VEGF and Caspase-3 levels were measured with the ELISA method. Results: Severe adhesions were observed in the AMT and control groups, but no adhesion was present in the MSC group. Pericardial thickness, increased vascularity, fibrosis, and collagen accumulation were similar between control and AMT groups, but were less in Sham and MSC groups. Between MSC and AMT groups, only Caspase-3 level was different, which is an apoptosis marker. Conclusion: The positive effects of MSC on adhesion, which we achieved in our study, suggest that it may prevent adhesion. AMT did not provide a positive effect. The correlation of Caspase-3 with postoperative adhesion/fibrosis should be examined in more detail.Öğe The association of angiopoietin-like peptide 4 levels with obesity and hepatosteatosis in adolescents(Academic Press Ltd- Elsevier Science Ltd, 2020) Dikker, Okan; Dag, Nevin Cetin; Sahin, Mustafa; Turkkan, Emine; Dag, HuseyinIntroduction: Angiopoietin-like peptide 4 (ANGPTL-4) is an adipocytokine that regulates plasma lipoprotein levels by inhibiting the lipoprotein lipase enzyme. Changes in lipid profile can be seen in obese adolescents. Nonalcoholic fatty liver disease may also be a complication of obesity. Based on this information, in this study we aimed to evaluate the relationship between serum ANGPTL-4 levels and obesity and hepatosteatosis in adolescents. Materials and methods: A total of 85 volunteer adolescents, 55 of them were obese and 30 of them were normal weight, were included in our study. The adolescents having body mass index (BMI) 95% percentile and over according to age and sex was defined as obese. Thirty patients with grade 2-3 hepatosteatosis in abdominal ultrasound (USG) were included in 'obese adolescents with hepatosteatosis' subgroup and 25 obese cases with no hepatosteatosis in the USG were included in the 'obese adolescents without hepatosteatosis' group. Thirty patients with no hepatosteatosis in the abdominal USG and having BMI in normal percentiles according to their age and sex constituted the 'healthy control adolescents' group. Serum ANGPTL-4 levels were measured by Enzyme Linked Immunosorbent Assay. Laboratory tests, gender, age and BMI levels were compared statistically between groups. Correlations between ANGPTL-4 and other laboratory parameters were examined statistically in obese adolescent group. Results: The BMI, ANGPTL-4, HbAl c, AST, ALT, total cholesterol, triglyceride, LDL-cholesterol, HOMA-IR and insulin levels of the obese adolescent group were found to be significantly higher than the healthy control group (p < 0.05). We found no statistically significant difference in BMI, ANGPTL-4, triglyceride, insulin and HOMA-IR levels among obese adolescents with or without hepatosteatosis (p > 0.05). In all obese adolescent groups and in obese adolescent group with hepatosteatosis; there was no statistically significant relationship between ANGPTL-4 and other variables (p > 0.05). Conclusions: We found that the levels of ANGPTL-4 increases in obesity in adolescents. However, our results make it difficult to establish a relationship between hepatosteatosis and ANGPTL-4. Targeting ANGPTL-4 may be beneficial for the pathogenesis and associated complications of obesity.Öğe The use of antioxidants against high ferritin-induced oxidation in COVID-19 patients: a biochemical approach(Springer-Verlag Italia Srl, 2020) Sahin, Mustafa[Abstract Not Available]
