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    Öğe
    Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population
    (2020) Pehlivan, Sacide; Çetinay, Pınar; Uysal, M. Atilla; Nursal, Ayşe Feyda; Kurnaz, Selin; Sever, Ulgen; Pehlivan, Mustafa
    Objective: Etiopathogenesis of schizophrenia (SCZ) involves several risk genes that induce inflammation, environmental stress factors and changes in the innate immune system. Patients with SCZ have the highest rate of cigarette smoking and severe nicotine dependence. Myeloperoxidase (MPO), a member of subfamily of peroxidases, is most abundantly expressed in immune cells. The aim of this study was to investigate the relationship between the MPO rs2333227 variant and SCZ/smoking etiopathogenesis. Method: The study included 54 patients with SCZ, 94 smokers and 92 healthy controls. MPO rs2333227 variant was genotyped by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method. Odds ratio (OR) and 95% confidence interval (95%CI) were calculated using the ?2 test. Results: G/G and G/A genotypes of MPO rs2333227 were detected in our study samples. The frequencies of the G/G and G/A genotypes were 53.7%, 46.3%; 56.3%; 43.7%; 68.9%, 31.1% in SCZ patients, smokers, and the control group, respectively. The allele frequencies were G: 76.9% (SCZ patients), 77.4% (smokers) 83.7% (controls); A: 23.1% (SCZ patients), 22.6% (smokers), and 16.3% (controls). There was no significant difference between the SCZ patients, smokers and controls regarding MPO rs2333227 variant either in terms of allele frequency or genotype frequency. Then we genotyped the groups as women and men. MPO rs2333227 variant genotype distribution did not differ between men and women (p>0.05). Conclusion: This study does not support the role of MPO rs2333227 variant in increasing genetic risk for SCZ/smoking in Turkish population.
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    Öğe
    Do UCP2, IL-17, mi196a2, and NR3C1 gene variants contribute to the risk of microtia? A preliminary study in Turkish population
    (Elsevier Science Bv, 2018) Ozdilli, Kursat; Bekerecioglu, Mehmet; Nursal, Ayse Feyda; Pehlivan, Mustafa; Sever, Ulgen; Buyukgural, Berker; Pehlivan, Sacide
    [Abstract Not Available]
  • [ X ]
    Öğe
    Impact of UCP2 -866G/A Variant on Smoking Risk
    (2021) Nursal, Ayşe Feyda; Uysal, M. Atilla; Pehlivan, Mustafa; Sever, Ulgen; Pehlivan, Sacide
    Objective: Mitochondria are multifunctional and dynamic organelles found in cells. Nicotine is a natural alkaloid found in the tobacco plant and has been well studied as a component of cigarette smoke. It has also been reported to affect mitochondrial function both in vitro and in vivo. Uncoupling protein 2 (UCP2) reduces generation of ROS by mitochondria. Our purpose in this study was to investigate whether the -866G/A variant of the UCP2 gene is associated with smoking status. Methods: A total of 238 individuals consisting of 138 smokers and 100 healthy controls were examined. The UCP2-866G/A variant was genotyped by polymerase chain reaction-restriction fragment length polymorphism method. Results: The proportion of individuals carrying the three possible genotype was significantly different between the smoker and healthy control groups. The UCP2-866G/A variant GG genotype was associated significantly with an increased risk of smoking (p=0.001) while AA genotype was associated significantly with a decreased risk of smoking (p=0.001). The UCP2-866G/A variant G allele was found to be increased in the smoker group compared to the healthy controls (p=0.001). Conclusion: Our data suggest that the UCP2-866 G/A variant GG genotype and G allele might reflect the risk of smoking status in a Turkish population