Yazar "Sezikli, Mesut" seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe An Analysis of the Differences of Gallstone Presence with Respect to the Variations of Biliary Tracts and Gender(2021) Medişoğlu, Mahmut Sabri; Çolak, Tuncay; Yalnız, Ahmet; Çam, İsa; Sezikli, Mesut; Baltrak, Yusuf AtakanObjectives: This study aims to investigate the gender in which gallstone formation is seen more frequently and whether hepatic and extrahepatic biliary tract variations are associated with gallstone formation. Methods: 60 patients who underwent endoscopic intervention and MRCP between 2017-2019 were included in the study. Patients with gastrointestinal complaints such as gallstones, gall bladder inflammation, Ductus choledochus (DCH) stones who have been admitted to the SBU Derince Training and Research Hospital's gastroenterology clinic were included in the study, and patients with secondary diseases such as diabetes, hypercholesterolemia were excluded from the study. In this way, 33 male and 27 female patients were included in the study and MRCP was carried out with all of them. Measurements were performed in all patients participating in the study. Variation types and the presence of gallstones were examined in MRCP images. Results: In 60 cases examined, the presence of gallstones was observed to be statistically significantly higher in women compared to men. There was no statistically significant relationship between biliary tract variations and gallstone formation (p=0.504). Conclusion: Gallbladder formation is found to be more common in women. The presence of biliary tract variations did not affect the development of the gallstone presence. It may be necessary to consider this phenomenon especially before surgical and radiological examinations to determine variational conditions and to conduct studies examining the relationship between this situation and gallstone formation.Öğe Çölyak Hastalarında D Vitamini Eksikliği ve Osteoporoz Sıklığı(2019) Kaya, Muhammed; Şipal, Selen; Polat, Umut; Sezikli, MesutGİRİŞ ve AMAÇ: Çölyak Hastalığı genetiği yatkın bireylerde diyette gluten proteininin alımıyla ortaya çıkan, ince barsaklarda inflamasyonla seyreden otoimmün bir hastalıktır. Vitamin eksiklikleri ve osteoporoz da önemli bulgularındandır. Çalışmamızda takipli çölyak hastalarında vitamin D eksikliği ve osteoporoz sıklığını değerlendirmek amaçlanmıştır. YÖNTEM ve GEREÇLER: Çalışmamıza kliniğimizde çölyak tanısıyla takip edilen 18-65 yaş arası 80 hasta ve kontrol grubu olarak 45 sağlıklı birey dâhil edilmiştir. Her iki grubun demografik özellikleri, antropometrik ölçümleri, hemogram, biyokimya, vitamin B12, folat, ferritin, vitamin D düzeyleri ile hasta gruba ait TTG IgA, TTG IgG ve KMD sonuçları sistemde kayıtlı verilerden elde edilmiştir. Çölyak hastaları TTG antikor pozitifliğine göre glutensiz diyete uyumlu ve uyumsuz olarak iki gruba ayrılmıştır. Diyete uyumlu ve uyumsuz çölyak hastaları ile sağlıklı kontrol grubuna ait veriler karşılaştırılarak SPSS 22 istatistik programı ile analiz edilmiştir. BULGULAR: Diyete uyumlu ve uyumsuz hasta grupları ile kontrol grubu yaş cinsiyet ve sigara kullanımı açısından benzer özelliklerdedir. Diyete uyumsuz çölyak hastalarında vücut ağırlığı, karaciğer fonksiyon testleri, hemogram ve anemi parametrelerinin kötüleştiği, diyete uyum gösteren hastalarda ise sağlıklı popülasyona benzer olduğu görülmektedir. Çalışmamızda çölyaklılarda vitamin D eksikliği yüksek oranda (%73,8) saptanmış, ancak sağlıklı kontrollerden farksız bulunmuştur. Çölyak hastalarının %55,1’inde osteopeni, %17,9’unda osteoporoz saptanmıştır. Glutensiz diyete uyumlu hastalarda %8,9 olan osteoporoz oranı diyete uymayan hastalarda %30,3 olarak saptanmış ve anlamlı ölçüde artış görülmüştür. TARTIŞMA ve SONUÇ: Diyete uyumsuz hastalarda hemogram, biyokimya, folat ve ferritin parametreleri anlamlı ölçüde bozulmaktadır. Vitamin D eksikliği hem çölyaklılarda hem de sağlıklı popülasyonda sık görülmektedir ancak çölyak hastalığı ve diyet uyumu ile ilişkisi saptanamamıştır. Osteoporoz, çölyak hastalarında sık görülmekte olup diyete uyumsuz hastalarda anlamlı ölçüde artmaktadırÖğe Global Publication Trends and Research Hotspots of the Gastric Neuroendocrine Neoplasms: A Bibliometric Analysis of the Current Situation(Pera Yayincilik Hizmetleri, 2024) Köseoğlu, Hüseyin; Kaya, Muhammed; Durak, İbrahim; Düzenli, Tolga; Kaymazlı, Mustafa; Sezikli, MesutObjective: Gastric neuroendocrine neoplasms (gNENs) are uncommon tumors, with growing understandings about the disease. Bibliometric analyzes have the advantage of visually depicting the dynamic evaluation of scientific knowledge of a specific topic. The aim of this study was to perform and report bibliometric analysis of gNENs, which was not formerly studied in the literature. Methods: Articles published between 1980 and 2022 within the database of Web of Science Core Collection were included in this bibliometric analysis. Vosviewer package program and Datawrapper were used for bibliometric data interpretation. Results: A total of 2270 articles about gNENs was detected with 63240 citations and an H index of 103. A remarkable increase was detected among the articles for years. Research have focused on gastroenterology and hepatology, endocrinology and metabolism, oncology, general medicine, pathology and surgery areas. Norwegian University of Science Technology was the leading institution about gNENs literature. Modlin IM, had the highest number of articles and citations among the authors. United States, Japan and Italy were the top three countries with the most published articles. Conclusion: This bibliometric study provides an engrossing, insightful conclusion to the research and development trajectory in gNENs with a future perspective.Öğe HBV flare associated with immunosuppressive treatments: it is still dangerous in the third-generation antivirals era(Int Medical Press Ltd, 2020) Toka, Bilal; Koksal, Aydın Şeref; Iskender, Gülşen; Çakmak, Erol; Üsküdar, Oğuz; Sezikli, Mesut; Hülagü, SadettinBackground: There are limited data about the mortality and morbidity of patients with HBV flare related to immunosuppressive treatments (IST) in the third-generation antivirals era. Herein, we performed a multi-centric study in patients treated with entecavir (ETV) or tenofovir disoproxil fumarate (TDF) and evaluated their clinical course. Methods: The study group included patients who were referred to gastroenterology or infectious disease specialists at eight different hospitals in Turkey. HBV flare was defined as at least a threefold elevation in alanine aminotransferase (ALT) levels above the upper limit of normal range. The demographic data, IST protocol, virological markers, liver tests, international normalized ratio (INR), HBV DNA, reactivation risk profile according to AGA guideline, MELD and MELD-Na scores were retrospectively evaluated. The primary aim of the study was to determine the liver-related mortality, including transplantation, at 12 weeks and factors predicting it. Secondary aims were to compare ETV and TDF with respect to mortality and time to ALT, bilirubin normalization and HBV DNA undetectability. Results: The study group included 40 patients (29 males, mean age: 57 +/- 12 years). Twenty-five patients (62.5%) had a high risk of reactivation. Twenty-six patients received TDF and 14 patients received ETV treatment. Eight (20%) patients developed acute liver failure and one patient (2.5%) underwent living donor liver transplantation. Seven patients died due to liver-related complications, revealing a mortality rate of 17.5%. In multivariate analysis, total bilirubin levels at the onset, ALT levels and delta-MELD score at the first week were the independent risk factors for liver related mortality (HR: 1.222, 1.003, 1.253 and 95% CI: 1.096, 1.362; 1.001, 1.004 and 1.065, 1.470, respectively). There was no significant difference between the TDF and ETV groups with respect to time to normalize ALT and bilirubin levels, HBV DNA undetectability and mortality rates (16% and 21.4%, respectively). Conclusions: HBV flare associated with 1ST has a high mortality in the third-generation antivirals era. High total bilirubin at the onset and high ALT and delta-MELD score at the first week predict poor prognosis.Öğe The Effect of Switch Treatment on Liver Fibrosis and qHBsAg Levels in Patients with Chronic Hepatitis B(2020) Yeşilyurt, Esra; Kaya, Muhammed; Dindar, Gökhan; Açıkgöz, Seyyid Bilal; Güzelbulut, Fatih; Sezikli, Hayrunnisa; Sezikli, MesutObjectives: The aim of this study was to evaluate the relationship between clinical, biochemical, serological parameters, fibroscan imaging in terms of fibrosis and quantitative hepatitis B surface antigen (qHBsAg) levels in patients with chronic hepatitis B (CHB) infection whose treatment has been switched from LAM to TDF. Materials and Methods: The study included 19 patients with CHB and under the LAM treatment. The gender, age, comorbidity, medications, routine laboratuary, creatinine clearance, bone mineral density, transient elastography for stage of liver fibrosis and qHBsAg level were examined. Results: Ten of 19 patients were female and 9 were male. When the qHBsAg titers of the patients at $6^th$ and $12^th$ months were compared, there was a statistically significant decrease in qHBsAg titers of the patients after the $12^th$ month. There was a significant decrease in liver fibrosis measurements at the $12^th$ month of treatment change. There was a statistically significant positive correlation between qHBsAg titers and fibroscan values at baseline and $12^th$ month Conclusion: In this study, the replacement of LAM with TDF may prevent the resistance problem, and also the decrease in fibrosis values and/or qHBsAg levels may contribute to the prevention of HCC and cirrhosis have been showed
