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    Immune mechanisms in human and canine demodicosis: A review
    (Wiley, 2019) Gazi, Umut; Taylan-Ozkan, Aysegul; Mumcuoglu, Kosta Y.
    Demodex mites are saprophytic parasites of the mammalian skin, mostly found in or near pilosebaceous units of hairy regions. While they can be found in healthy humans and animals without causing any clinical manifestations, they were suggested to create pathogenic symptoms when they appear in high densities under favourable conditions (ie, demodicosis). Nevertheless, their role as the primary causative agent of the pathogenic conditions in humans is debated today. Canine demodicosis, which is highly prevalent in certain dog breeds, provides a valuable tool for studying the pathogenesis of human demodicosis. Canine and human demodicosis are caused by different Demodex species, and the clinical manifestations in former could be life-threatening. Nevertheless, current literature suggests similar immune responses and immune evasion mechanisms in human and canine demodicosis; cellular immunity appeared to have a central role in protection against demodicosis, and Demodex mites were shown to influence both innate and adaptive immune response to escape immune attack. The aim of this review is to summarize the relevant literature on demodicosis obtained from studies conducted on both organisms, and draw the attention to the effect of mite-associated factors (eg, microbiota) on the different clinical manifestations displayed during human and canine demodicosis.
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    Sources and seroprevalence of toxocariasis in Turkey
    (Academic Press Ltd-Elsevier Science Ltd, 2020) Taylan-Ozkan, Aysegul
    Toxocariasis in humans is considered a rare disease in Turkey, and the absence of specific symptoms of this disease is probably the main reason for clinicians to underestimate and underdiagnose the disease. Although there are several seroepidemiological studies on visceral larva migrans in the country, a comparison between them is difficult as the serological tests are not standardised. After the introduction of the easily accessible ELISA kit in the market, the number of seroepidemiological studies has increased in which the reported rates ranged between 1% and 56%. Similar to other countries, Toxocara seropositivity in Turkey is more common in men, childhood, in those living in rural area, having a low income level, owning dogs, and biting their nails or practicing geophagia. In addition, toxocariasis is a risk factor for veterinarians, farmers, and pet-shop workers. Toxocara seroprevalence is significantly higher in respiratory, neuropsychiatric, musculoskeletal, skin and abdominal disorders. There are also many studies showing the importance of eosinophilia in toxocariasis. In conclusion, although there are many studies on toxocariasis in Turkey, it is still not well understood to what extent the infection is responsible for a plethora ascribed symptoms. Standardisation of the diagnostic methods and the use of molecular techniques could further throw light in the real epidemiology and the role played by the infection to induce signs and symptoms.