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    Macrophage migration inhibitory factor -173GC variant might increase the risk of behçet's disease
    (S. Karger AG, 2018) Nursal, Ayşe Feyda; Yiğit, Serbülent; Tural, Ercan; Kalkan, Göknur; Tümer, Mehmet Kemal; Tekcan, Akın
    Objective: The aim of the present study was to investigate any possible association between the macrophage migration inhibitory factor (MIF) -173GC variant and Behçet's disease (BD) in a group of Turkish patients. Subjects and Methods: A total of 111 patients with BD and 100 healthy controls were enrolled in this study. Genomic DNA was extracted from peripheral lymphocytes. The MIF -173GC variant was genotyped using polymerase chain reaction restriction fragment length polymorphism. The allele and genotype frequencies of patients and controls were compared using the ?2 test. Results: A statistically significant difference in the distribution of the genotype was observed between BD patients and healthy controls. The homo-genotype CC was more prevalent in the patient group compared to the control group (p = 0.008, OR: 0.24, 95% Cl: 0.05-0.78). A significant association was observed when the patients were compared with the controls according to GG + GC versus CC ge-notypes (p = 0.003, OR: 1.21, 95% CI: 0.06-0.063). Allele frequencies of the MIF -173GC variant did not show any statistically significant difference between patients and controls. Conclusion: In this study, we conclude that the CC ge-notype of the MIF -173GC variant may be a risk factor in the pathogenesis of BD in the Turkish population. However, further studies with larger samples are needed to address the exact role of this variant in BD. © 2018 The Author(s) Published by S. Karger AG, Basel.
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    Physical activity levels of teachers and health professionals in Turkey
    (DRUNPP Sarajevo, 2012) Atan, Tülin; Tural, Ercan; İmamoğlu, Osman; Çiçek, Güner; Tural, Şengül
    Purpose: The purpose of this study was to examine the physical activity level of teachers and health professionals and to investigate whether there were differences in physical activity level between two separate groups. Method: To determine the physical activity levels International Physical Activity Questionnaire (IPAQ) was applied to 200 teachers (age; 36.28±6.58) including 92 male and 108 female working in primary schools and 200 health professionals (age; 33.63±7.55 years) including 62 male and 138 female working in university hospital. The short-form of IPAQ which includes last one week containing the 7 item has been used to determine the physical activity levels. Mann Whitney-U test was used to evaluate the differences between two groups. The relations of parameters, such as profession, age, gender, branch, height, weight, drug alcohol and tobacco use and marital status with Physical Activity level were analyzed by using Chi-Square test. Results: The weekly physical activity score of teachers and health professionals were 1544.58 MET-min/week and 1986.59 MET-min/week respectively and no statistically difference was found (p>0.05). Health professionals' walking activity and time of sitting were found higher than teachers (p<0.05 and p<0,01). Physical activity scores were not found significantly different between male teachers and male health professionals (p>0.05). Total physical activity scores, walking activity scores and sitting times were found significantly higher in female health professionals than female teachers (p<0.05; p<0.01). Conclusion: Total physical activity levels of teachers and health professionals were not different and insufficient. The physical activity level increase in teachers and decrease in health professionals with increasing age and with smoking. Gender difference and marriage affects the physical activity level of teachers but does not affect the health professionals. Physical activity level was not different according to drug, alcohol consumption and BMI in both occupation groups. As raecdti Physical Activity level in terms of some variables differed between two professional Groups.