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    Evaluation of YouTube Videos as a Source of Information on Hepatosteatosis
    (CUREUS INC, 2023) Tutan, Duygu; Kaya, Muhammed
    Introduction Individuals frequently turn to YouTube as a source of information about their medical conditions and potential treatment options. Among the common ailments affecting the general population, hepatosteatosis stands out due to its severe consequences in the absence of proper treatment. The primary objective of this study is to evaluate the quality of hepatosteatosis-related videos available on the YouTube platform, and the secondary objective is to determine if there is a difference in video quality between videos uploaded by medical professionals and other sources. Methods The process of selecting videos for this study involved evaluating their relevance after conducting a search using the keywords "hepatosteatosis," "fatty liver," and "hepatic steatosis" on YouTube. This search was conducted on August 18, 2023. From the search results, we identified and selected the top 50 most-watched videos in the English language. These selected videos were then rigorously assessed for their relevance and content by three independent medical professionals. Additionally, various descriptive attributes of each video, such as the upload date, subscriber count, view count, likes, dislikes, and comments, were meticulously recorded in the dataset. To determine the quality of these videos, we utilized three evaluation tools: the DISCERN Score, the Global Quality Score (GQS), and the Journal of the American Medical Association (JAMA) rating scales. We have used the median±interquartile range (IQR), mean±standard deviation (SD), and the range of minimum to maximum values to convey descriptive statistics. The distribution was evaluated with the Shapiro-Wilks test. Spearman correlation analysis was used to identify relationships between variables. The association between quality indicators and data was examined using multiple regression analysis. The Mann-Whitney U test was used to determine significant differences between groups. A statistical significance level of 0.05 was considered significant. Results Our study revealed notable statistical differences in DISCERN scores when comparing videos uploaded by medical doctors to those uploaded by individuals without medical qualifications (p < 0.001). Likewise, in the comparisons between these two groups, videos created by healthcare professionals consistently demonstrated significantly higher quality scores in both the JAMA and GQS evaluations (p < 0.001 for both comparisons). This suggests that videos uploaded by medical professionals tend to provide higher-quality information on the topic of hepatosteatosis compared to those uploaded by non-medical individuals. Video length and comment counts were also found to be significant in the multivariate linear regression analysis and were predictive of the DISCERN score (p = 0.047 and p = 0.037, respectively). Conclusions The quality of information related to hepatosteatosis on YouTube varies significantly. Surprisingly, there is no noticeable difference in terms of views and popularity between helpful and potentially misleading videos. For individuals seeking reliable information, it is advisable to prioritize videos uploaded by medical professionals. Paying attention to the qualifications of the content creator rather than the video's popularity or view count is crucial when seeking accurate and trustworthy information on hepatosteatosis.
  • Küçük Resim
    Öğe
    Predictive Value of Serial Rapid Shallow Breathing Index Measurements for Extubation Success in Intensive Care Unit Patients
    (MDPI, 2024) Turhan, Semin; Tutan, Duygu; Şahiner, Yeliz; Kısa, Alperen; Önen Özdemir, Sibel; Tutan, Mehmet Berksun; Kayır, Selçuk; Doğan, Güvenç
    Abstract: Background and Objectives: Extubation success in ICU patients is crucial for reducing ventilator-associated complications, morbidity, and mortality. The Rapid Shallow Breathing Index (RSBI) is a widely used predictor for weaning from mechanical ventilation. This study aims to determine the predictive value of serial RSBI measurements on extubation success in ICU patients on mechanical ventilation. Materials and Methods: This prospective observational study was conducted on 86 ICU patients at Hitit University between February 2024 and July 2024. Patients were divided into successful and unsuccessful extubation groups. RSBI values were compared between these groups. Results: This study included 86 patients (32 females, 54 males) with a mean age of 54.51 ± 12.1 years. Extubation was successful in 53 patients and unsuccessful in 33. There was no significant difference in age and intubation duration between the groups (p = 0.246, p = 0.210). Significant differences were found in RSBI-1a and RSBI-2 values (p = 0.013, p = 0.011). The median RSBI-2a was 80 in the successful group and 92 in the unsuccessful group (p = 0.001). The ?RSBI was higher in the unsuccessful group (p = 0.022). ROC analysis identified optimal cut-off values: RSBI-2a ? 72 (AUC 0.715) and ?RSBI ? ?3 (AUC 0.648). RSBI-2a ? 72 increased the likelihood of successful extubation by 10.8 times, while ?RSBI ? ?3 increased it by 3.4 times. Using both criteria together increased the likelihood by 28.48 times. Conclusions: Serial RSBI measurement can be an effective tool for predicting extubation success in patients on IMV. These findings suggest that serially measured RSBI may serve as a potential indicator for extubation readiness.
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    Öğe
    Son dönem böbrek yetmezliği nedeni ile diyaliz tedavisi alan hastalarda selenyum düzeyi ve kognitif fonksiyonlar arasındaki ilişki
    (Hitit Üniversitesi, 2021) Tutan, Duygu; Eser, Barış
    Amaç: Kronik böbrek hastalarının (KBH) %16-38'inde geliştiği bildirilen kognitif fonksiyonlarda bozulmanın morbidite ve mortaliteyi artırıcı bir faktör olduğu bilinmektedir. Selenyumun antioksidan etkiyle serbest radikallerin neden olduğu nöronal hasarı önleyerek kognitif bozulmayı engelleyici etki gösterdiği bilinmektedir. Bu çalışmada KBH olanlarda serum selenyum düzeyinin kognitif fonksiyon bozukluğu ve depresyon ile ilişkisi araştırılmıştır. Gereç ve yöntem: Bu klinik kesitsel çalışmaya 20-65 yaş arasında toplam 100 katılımcı [hemodiyaliz tedavisi uygulanan (HD) (n=25), sürekli periton diyaliz tedavisi uygulanan (PD) (n=25), evre 3-4 KBH (n=25), KBH olmayan kontrol grubu (n=25) katılımcı] dahil edildi. Kognitif fonksiyonları değerlendirmek için Standardize Mini Mental Test (sMMT), depresyon varlığının tespiti için ise Beck Depresyon Ölçeği (BDÖ) uygulandı. Eş zamanlı, serum selenyum düzeyi ölçümleri için kan örnekleri alındı. Bulgular: KBH olan hastaların (n=75) %16'sında, diyaliz tedavisi uygulanan hastaların (n=50) %30'unda ve KBH olmayan kontrol grubunun %4'ünde kognitif fonksiyon bozukluğu tespit edilmiştir. HD hastalarının %44'ünde, PD hastalarının %50'sinde, evre 3-4 KBH hastalarının %40'ında ve kontrol grubunun %16'sında orta veya şiddetli depresyon saptanmıştır. KBH olmayan kontrol grubunda sMMT puanları diğer gruplara göre anlamlı olarak daha yüksek iken (sırasıyla, P<0,001, P<0,001, P<0,001), BDÖ skoru daha düşüktür (P=0,003). Post-hoc test analizlerinde serum selenyum düzeyleri; diyaliz uygulanmayan KBH'lılar ve kontrollerde, HD ve PD gruplarından anlamlı olarak yüksek bulunmuştur (sırasıyla, P=0,001, P<0,001, P<0,001, P<0,001). Serum selenyum düzeyi ile sMMT skorları arasında pozitif yönde istatistiksel olarak anlamlı korelasyon saptanmıştır (r=0,299; P=0,003). Serum selenyum düzeyi ile BDÖ skorları arasında negatif yönde anlamlı ilişki saptanmıştır (r=-0,301; P=0,002). Sonuç: KBH hastalarında özellikle diyaliz hastalarında kognitif bozulma ve depresyon sık görülmektedir. Bulgularımız bu hasta popülasyonunda serum selenyum eksikliğinin hem kognitif bozulma hem de depresyon üzerine katkısı olabileceğini düşündürmektedir. Bununla birlikte, bulgularımız daha kapsamlı araştırmalar ile desteklenmelidir.
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    The relationship between neutrophil lymphocyte ratio, platelet lymphocyte ratio, and depression in dialysis patients
    (LIPPINCOTT WILLIAMS & WILKINS, 2023) Tutan, Duygu; Erdoğan Kaya, Ayşe; Eser, Barış
    Chronic kidney disease is a worldwide public health issue with rising incidence, morbidity/mortality, and cost. Depression and chronic renal disease often coexist, and psychological illnesses are associated with poor results. Early identification of depression reduces morbidity and death. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are reported as practical biomarkers of inflammation and immune system activation. In this study, we aimed to determine the association of NLR and PLR with depression in dialysis patients. This study included 71 adults over 18 without known hematologic or oncologic disease, drug use, or chronic inflammatory diseases. Comorbid chronic diseases, laboratory data, and Beck depression inventory scores were prospectively recorded. A comparison of 2 groups according to the existence of depression was made, and a binomial logistic regression test was used to determine the association between the variables and the presence of depression after adjusting for confounding factors. A receiver operating curve analysis was used to differentiate groups with and without severe depression. Seventy-one patients met the study criteria, with 46 hemodialysis and 25 peritoneal dialysis patients. The majority had hypertension and diabetes mellitus, with 47.89% having minimal-minor depression and 52.11% having moderate-major depression. The 2 groups were similar regarding chronic diseases, with no significant differences in serum creatinine levels, glucose, lipid profiles, or electrolytes. However, when the NLR of the 2 groups was compared, the median was higher in patients with moderate or major depression. Multivariate analysis showed no significant differences between the groups in PLR, triglyceride to glucose ratio, and C-reactive peptide to albumin ratio. The best NLR cutoff value was 3.26, with 48.6% sensitivity, 88.2% specificity, 81.8% positive predictive value, 61.2% negative predictive value, and 67.6% test accuracy. Depression is one of the most common psychiatric conditions in dialysis patients and is linked to increased morbidity, mortality, treatment failure, expense, and hospitalization. NLR helped predict moderate-to-major depression in dialysis patients, even after controlling for confounding factors in multivariate analysis. This study indicated that an NLR successfully identified depressive groups, and patients with an NLR value >3.26 were 6.1 times more likely to have moderate or major depression. Abbreviations: CAR = C-reactive peptide to albumin ratio, CI = confidence interval, CKD = chronic kidney disease, CRP = C-reactive peptide, NLR = neutrophil to lymphocyte ratio, PDW = platelet distribution width, PLR = platelet to lymphocyte ratio, ROC = receiver operating curve, TSH = thyroid stimulant hormone, TyG = triglyceride to glucose ratio, WBC = white blood cell count