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Öğe Association between Alzheimer’s disease, MAPT genemutation and some biochemical biomarkers(TAYLOR & FRANCIS INC, 2024) Şen, Ayşenur; Avşar, Orçun; Eliaçık, Sinan; Uysal Tan, FundaAlzheimer’s Disease (AD) is a multifactorial neurodegenerativedisease and there is still no definitive treatment today. Earlydiagnosis of the disease is important, but there are almost nobiomarkers that can be used in early diagnosis. The cerebro-spinal fluid used in the diagnosis of the disease is not suffi-cient and is very difficult to obtain. Therefore, blood biomarkersthat are less costly, less invasive, easily accessible, and can beused in long-term studies would be a better alternative. Theaim of this study is to determine the relationship betweenAlzheimer’s Disease and P301L MAPT gene mutation, homo-cysteine, folate and uric acid. 101 Alzheimer’s patients and101 healthy individuals were included in this study. Mutationanalysis was performed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) methodwith blood samples taken from the subjects. There was nosignificant difference between the patient and control groupsin terms of homocysteine (p = 0.771), folate (p = 0.366) and uricacid (p = 0.860). When the genotypes were compared betweenthe patient and control groups in terms of MAPT gene muta-tion (P301L), no statistically significant difference was detected(p = 0.081). There are very few studies in the literature investi-gating the relationship between Alzheimer’s disease and P301LMAPT gene mutation. Additionally, there is no study investigat-ing the relationship between Alzheimer’s disease and homocys-teine, folate, uric acid and P301L MAPT mutation in the Turkishpopulation. We believe that this study has shed light on futurestudies.Öğe Clinical Manifestations of Overactive Bladder With Migraine as a Comorbidity: A Prospective Cross-Sectional Study(Korean Continence Soc, 2020) Başer, Aykut; Eliaçık, Sinan; Baykam, Mehmet Murat; Uysal Tan, FundaPurpose: The aim of this study was to investigate the clinical manifestations of overactive bladder (OAB) with migraine as a comorbidity and to shed light on possible new treatment. strategies. Methods: This study included patients aged 18 years and older who were admitted to urology and neurology outpatient clinics between March 1, 2019 and March 1, 2020 for OAB and migraine. The study questionnaire contained 3 sections: (1) questions on demographic characteristics, (2) a migraine II) test, and (3) the Overactive Bladder Inquiry Form - V8 (OAB-V8) form. Results: A total of 265 patients participated in the study. The average age of the participants was 39.75 +/- 11.93 years. The patients were divided into 3 groups according to the coexistence of OAB with migraine: group 1, OAB(+)/migraine(+); group 2, OAB(+)/migraine(-); and group 3, OAB(-)/migraine(+). The mean OAB-V8 score was 22.82 +/- 8.15 in group 1 and 25.64 +/- 7.49 in group 2. The mean OAB-V8 score of OAB patients with migraine as a comorbidity was statistically significantly lower than that of OAB patients without migraine (P = 0.015). The median visual analogue scale (VAS) score was 7.11 (range, 2-10) in group 1 and 5.95 (range, 2-10) in group 3. This finding indicates that in patients with migraine, having OAB was associated with significantly higher VAS scores (P <0.001). Conclusions: OAB and migraine may be comorbid conditions coexisting in a single patient. This comorbidity may lead to a lower perception of OAB symptoms in OAB patients or, conversely, to a higher perception of migraine pain. Further studies are needed to elucidate how treatments for each of these diseases can affect the other disease.Öğe Effects of Chronic Migraine on Male Sexual Health(COLL PHYSICIANS & SURGEONS PAKISTAN, 2022) Baykam, Mehmet Murat; Başer, Aykut; Yılmaz Başer, Hülya; Eliaçık, Sinan; Uysal Tan, FundaObjective: To investigate the clinical implication of the sexual functions of male patients diagnosed with chronic migraine (CM) compared with the healthy population. Study Design: Observational study. Place and Duration of Study: Departments of Urology and Neurology, Hitit University Hospital, Turkey, from August 2019 to August 2020. Methodology: A total of 179 patients (92 subjects diagnosed with CM and 87 control healthy volunteers) were included in this study. Demographic descriptive data including age, height, weight, and body mass index (BMI) of all patients were recorded. A 5-question version of the international index of erectile function questionnaire (IIEF-5) was applied to evaluate their sexual functions. Furthermore, a migraine identification test was performed for CM patients for the diagnosis of migraine in accordance with the International Headache Society's (IHS) definition of chronic migraine. Visual analog scale (VAS) scores between 0-10 points were recorded for the qualitative assessment of migraine pain. Results: The IIEF-5 scores of CM patients [16 (11 – 21)] were lower compared to the control patients [21 (19 – 23), pÖğe Investigation of the relationship between ACAN geneVNTR polymorphism and Alzheimer’s disease inTurkish population(TAYLOR & FRANCIS INC, 2024) Keskin, Tuğba; Avşar, Orçun; Eliaçık, Sinan; Uysal Tan, FundaAlzheimer’s disease is one of the most common causes of dementia and is a neurodegenerative disease that occurs with memory loss, loss of language, thinking and problem-solving skills. In this study, it was aimed to reveal the relationship between Alzheimer’s disease and the variable number tandem repeat (VNTR) polymorphism in the aggrecan (ACAN) gene. Thus, it is thought that it will contribute to enlightenment about disease by contributing to the pathophysiology of Alzheimer’s disease. A total of 203 people, including 102 patients diagnosed with Alzheimer’s and 101 healthy individuals, were included in the study. Deoxyribonucleic acid (DNA) extraction was performed from the blood samples taken. The variable number tandem repeat (VNTR) polymorphism of the ACAN gene was determined using the Polymerase Chain Reaction (PCR) method. In our study, the 30?R, 31?R and 33?R alleles were the most repetitive alleles in patients and controls. 30?R, 31?R and shorter alleles were more common in patients than in the control group and were found to be statistically significant (p?=?0.042). According to our results, 30?R and 31?R alleles of the VNTR polymorphism in the ACAN gene may be associated with Alzheimer’s disease. In addition, having less than 30 repeat alleles increases the risk of the disease by 2,202 times. Our study is the first to investigate the relationship between ACAN gene VNTR polymorphism and Alzheimer’s disease. Further studies are needed to definitively relate it.Öğe Partial status epilepticus in cerebral venous sinus thrombosis, initial manifestation of polycythemia vera(Wolters Kluwer Medknow Publications, 2019) Eliaçık, Sinan; Savaş, Ömer Önder; Komut, Erdal; Uysal Tan, FundaCVT Cerebral venous sinus thrombosis (CVT) is a heterogeneous disorder, with a wide spectrum of clinical presentation and marked risk factors mainly genetic or acquired prothrombotic disorders.[1] We present a case of polycythemia vera (PV) initially presenting with cerebral venous sinus thrombosis (CVT).Öğe Posterior reversible encephalopathy syndrome associated with Neisseria elongata meningitis(Czech Medical Soc, 2020) Eliaçık, Sinan; Akdoğan, Özlem; Uysal Tan, Funda[Abstract Not Available]
