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Öğe Bibliometric Analysis of Top 100 Most Cited Articles Related To “Liver Transplantation” in Anesthesia Literature(2020) Kayır, Selçuk; Doğan, Güvenç; Yağan, Özgür; Hancı, VolkanObjective: For treatment of acute liver failure, end-stage liver diseases and liver-sourced malignant tumors, liver transplantation is a treatment method applied as a last resource. In our study, the aim was to assess 100 articles with most citations about liver transplantation in the anesthesia literature. Methods: Our study used the “advanced mode” feature of the “Institute for Scientific Information (ISI) Web of Science (WOS)” search engine. The search was performed on 11.12.2018 and 100 articles with most citations related to liver transplantation were determined. For each article, total citation number, annual citation number, authors, and catalogue information for the study and journal were determined using Web of Science (WOS) and PubMed. Results: The total mean number of citations for 103 studies with most citations was determined as 75.87±68.48. The annual citation numbers for the studies varied from 34.18 to 1.15, with mean of 4.98±4.60. When the areas of focus of the studies are investigated, the first three areas were transfusion practice in 17 articles (16.5%), thromboelastography in14 (13.6%) and hemodynamic monitoring in 10 (9.7%). The mean number of citations of authors from the European continent was significantly higher than authors from other continents (p<0.01). Conclusion: Our study is the first to evaluate and analyze the top 103 articles receiving most citations related to liver transplantation in the anesthesia literature. Bibliographic studies created using scientific search engines are illustrative of the topics of focus for authors and researchers.Öğe Comparison of the effects of continuous versus intermittent enteral feeding on plasma leptin and ghrelin levels in Intensive Care Units(Pontifícia Universidade Católica de Campinas, 2017) Yağan, Özgür; Taş, Nilay; Ayyıldız, Sema Nur; Karakahya, Murat; Noyan, TevfikObjective The aim of this prospective randomized trial is to verify whether there is an association between the methods of administration of enteral nutrition and the leptin and ghrelin hormones, which have a major role in the regulation of energy metabolism. Methods This study enrolled 38 enteral-fed patients aged 18 to 85 in the Intensive Care Unit. The patients were prospectively randomized to receive either continuous infusion (n=19) or intermittent feeding (n=18) of enteral nutrition. In addition to routine biochemical assays, blood samples were taken from the patients for leptin and ghrelin analyses on the 1th, 7th, and 14th days of enteral nutrition. Results There was no statistically significant difference between the groups regarding descriptive statistics and categorical variables such as underlying diseases, complications, steroid use and others (p > 0.05). The decrease in the number of white blood cells and in creatinine and C-reactive protein levels over time were statistically significant (p=0.010, p=0.026, p < 0.001 respectively). There was no statistically significant difference between the groups with respect to leptin and ghrelin levels (p=0.982 and p=0.054). Leptin levels did not change over time; however, the ghrelin levels of both groups were significantly higher on the 7th and 14th days than on the first day of analysis (p=0.003). Conclusion This study revealed that both continuous and intermittent enteral nutrition feeding regimens were well tolerated in Intensive Care Unit patients showing minor complications. The method of administration of enteral nutrition alone did not affect the leptin and ghrelin levels. Randomized controlled large cohort trials are needed to to compare intermittent and continuous enteral nutrition to determine which one is more adaptable to diurnal patterns of secretion metabolic hormones.Öğe Comparison of the effects of Neostigmine and Sugammadex on Colonic Anastomotic Strength in Rats(Academic Press Inc., 2020) Doğan, Gül; Doğan, Güvenç; Kayır, Selçuk; Yağan, Özgür; Hancı, VolkanBackground:After colorectal surgery, anastomotic leakage is a major cause of mortality andmorbidity. There are many factors affecting anastomotic leakage. It is known that agentssuch as neostigmine that is used to reverse neuromuscular blockade have certain effectson anastomosis. In our study, in which we planned to test this hypothesis, we aimed tocompare the possible effects of different doses of sugammadex and neostigmine on colonanastomosis strength in a colonic resection anastomosis model in rats.Materials and methods:Forty adult Wistar albino male rats were divided into five groups ascontrol (group C), Sugammadex 16 mg/kg (group SL), sugammadex 96 mg/kg (group SH),neostigmine 0.3mmol/kg (group NL), and neostigmine 1.5mmol/kg (group NH). The trans-verse colons of all rats were resected, and colonic anastomosis was performed. Appropriatedrug doses according to the groups were given on the postoperative seventh day, and tissuehydroxyproline (TH) level and anastomotic bursting pressure were measured.Results:Anastomotic bursting pressure values were statistically significantly different be-tween the groups (P¼0.001). The bursting pressure in group SH was significantly highercompared with group C, group NL, and group NH. The hydroxyproline values were sta-tistically significantly different between the groups (P¼0.015). According to the post hoctest results, the difference was between group SH and group C (P¼0.007). There were nosignificant differences between the other groups (P>0.05). There was no significant dif-ference in terms of intra-abdominal adhesion rates between the groups.Conclusions:In our study, we found that low and high doses of neostigmine had no variableeffect on anastomosis, but high dose of sugammadex (96 mg/kg) had an increasing effecton intestinal anastomosis strengthÖğe Effect of sugammadex on recovery from ketamine anesthesia: An experimental study(2020) Kayır, Selçuk; Doğan, Güvenç; Yağan, Özgür; Hancı, VolkanAim: Previous studies have shown cyclodextrins bind to a variety of medications. The hypothesis in our study is to determine whether or not sugammadex interacts with the lipophilic medication of ketamine to shorten the effect duration and ensure earlier recovery. Material and Methods: The study used 24 adult male Sprague-Dawley rats. Rats were randomly divided into 4 equal groups. Each rat was administered 75 mg/kg ketamine intraperitoneal (ip) bolus and then in the fifth minute rats was administered sugammadex at appropriate doses for their group through the lateral vein in the tail. Group C (control group) were administered 15 mL/kg physiologic serum (PS) (n=6), Group Sgdx 16 were administered 16 mg/kg sugammadex (n=6), Group Sgdx 100 were administered 100 mg/kg sugammadex (n=6) and Group Sgdx 1000 were administered 1000 mg/kg sugammadex (n=6). The heart rate, respiratory rate and recovery durations of the rats were recorded. Results: The recovery duration in the Sgdx 100 group was statistically significantly shorter compared to the control group (p=0.026), while the recovery duration in the Sgdx 1000 group was statistically significantly shorter than the control group (p<0.001) and the Sgdx 16 group (p=0.015). Heart rate was statistically significantly low in the Sgdx 1000 group compared to the control group (p<0.05). Respiratory rates were similar. Conclusion: Our study showed that 100 mg/kg and 1000 mg/kg sugammadex doses significantly shortened recovery. We conclude that there is a need for more research about the interaction between ketamine and sugammadex.Öğe Evaluation of the Effect; of Menstrual Cycle Phaseson Preoperative Anxiety(2020) Kayır, Selçuk; Ekici, Arzu Akdağlı; Doğan, Güvenç; Yağan, Özgür; Kısa, Alperen; Yalvaç, Mehmet; Kayır, TubaAim: The menstrual cycle has two phases, before ovulation (follicularphase) and after ovulation (luetalphase). Inbothphase periods, a physiological fluctuationprocess is observed dueto hormonal changes. Stress and anxietymayoccur in many patients who will undergo surgery. The aim of this study is to evaluate the effects of patients under going surgery on anxiety in different periods of the menstrual cycle. Methods: Eighty patients between the ages of 20-45, who were planned to under goelective surgery, who had a physical status of ASA I-II, regularmenstrualcycle, were not in meno pause, had nopremenstrualtension, and did not use oral contraceptiveagents. Inthestudy, data were collectedusing Spielberg's State-Trait Anxiety Inventory (STAI 1-2) [State Anxiety Inventory (STAI1),Trait Anxiety Inventory (STAI2)] and Visual Analogue Scale (VAS). Results: The meanage of the Follicular Phase group was 31.09 ± 7.77 and the meanage of the Luteal Phasegroupwas 32.26 ± 7.41. Meanages were similar between the groups(p=0.493).STAI1and Anxiety scores were statistically significantly higher in the lutealphase group(p=0.034, p=0.028,respectively). STAI2scoreswere not statistically different between the groups (p=0.180).Öğe Preoperative Vitamin D levels and respiratory complications of general anesthesia(Wolters Kluwer Medknow Publications, 2018) Taş, Nilay; Noyan, Tevfik; Yağan, Özgür; Hancı, Volkan; Çanakçı, EbruAims: This research aims to investigate whether there is a correlation between the respiratory complications occurring in patients under general anesthesia and preoperative Vitamin D levels. Settings and Design: The study was a prospective observational study. Materials and Methods: This study included 95 adult cases. The cases had total 25-hydroxyvitamin D (25OHD) levels identified in blood samples before the operation. Patients given routine general anesthesia and were assessed in terms of respiratory complications during anesthesia induction, extubation, anesthesia recovery, and the first 24-h postoperative. Statistical Analysis Used: The Shapiro-Wilk test, Student's-t-test, one-way ANOVA test, Pearson correlation coefficient, and Chi-square tests were used. Results: The mean 25OHD vitamin level identified in the preoperative period was 13.00 ± 6.57 ng/mL, with 25OHD vitamin levels found to be significantly low in female cases compared to male cases (P < 0.05). There was a statistically significant negative relationship between age and 25OHD vitamin levels identified (P = 0.045). When assessed in terms of surgery types, there was no significant difference found in Vitamin D levels in terms of surgery type. When examined for complications in the induction, extubation period, and postoperative recovery period, there was a significant difference identified between 25OHD vitamin levels and these complications (P < 0.01). Conclusions: This research observed that patients with low preoperative 25OHD vitamin levels encountered respiratory complications related to general anesthesia more often. Especially, in the early postoperative period, there is a very significant difference between complications and low 25OHD vitamin levels. © 2018 Nigerian Journal of Clinical Practice | Published by Wolters Kluwer - Medknow.Öğe RE: The effect of atropine in preventing catheter-related pain and discomfort in patients undergoing transurethral resection due to bladder tumor: a prospective, randomized, controlled study reply(Korean Pain Soc, 2020) Şahiner, Yeliz; Yağan, Özgür; Akdağlı Ekici, Arzu; Ekici, Musa; Demir, EmreWe would like to contribute to the recent critique responding to our article titled “The effect of atropine in preventing catheter-related pain and discomfort in patients undergoing transurethral resection due to bladder tumor: a prospective, randomized, controlled study” [1]. First, we also would like to thank our colleagues for their valuable contributions.Öğe The effect of atropine in preventing catheter-related pain and discomfort in patients undergoing transurethral resection due to bladder tumor; prospective randomized, controlled study(Korean Pain Soc, 2020) Şahiner, Yeliz; Yağan, Özgür; Akdağlı Ekici, Arzu; Ekici, Musa; Demir, EmreBackground: Catheter-related bladder discomfort (CRBD) has been observed in many patients undergoing a urethral catheterization. CRBD may be so severe that the patients require additional analgesics. Muscarinic receptors are involved in the mechanism of CRBD. The aim of this study is to determine the effects of the antimuscarinic properties of atropine, which is frequently used in current practice on CRBD, by comparing it with sugammadex which has no antimuscarinic effects. Methods: Sixty patients selected for transurethral resection due to bladder tumors were randomized into 2 groups: an atropine group and a sugammadex group, with no antimuscarinic effect. The patients were given rocuronium (0.6 mg/kg) as a neuromuscular-blocker. In addition to the frequency and severity of CRBD postoperatively at 0, 1, 6, 12, and 24 hours, postoperative numeric rating scale (NRS) scores, and postoperative nausea and vomiting were examined. Results: The incidence of CRBD was significantly lower in the atropine group in all postoperative measurements. The score was found to be significantly lower in the atropine group when NRS measurements were performed at all time periods (P < 0.01). There was no difference between the groups in terms of nausea and vomiting (P > 0.05). Conclusions: Atropine is a cheap, easy-to-access, safe-to-use drug for reducing CRBD symptoms, without any observed adverse effects. Since it not only reduces CRBD symptoms but also has a positive effect on postoperative pain, it can be used safely to increase patient comfort in patients receiving general anesthesia and a urinary catheter.Öğe Tracheotomy Among Patients In Geriatric Age Group Treated In Intensive Care Units(2019) Doğu, Cihangir; Kayır, Selçuk; Doğan, Güvenç; Akdağlı Ekici, Arzu; Özçiftçi, Serhat; Yağan, ÖzgürIntroduction: In intensive care units, numerous geriatric patients are mechanically ventilated, and those with prolonged mechanical ventilation show high mortality. Such geriatric patients may greatly benefit from tracheotomy because it facilitates pulmonary care, increases patient comfort and helps wean them off mechanical ventilation. Materials and Method: A total of 70 mechanically ventilated geriatric patients were includ-ed. Patients’ electronic data, file records, age, sex, mechanical ventilation requirement, Acute Physiology and Chronic Health Evaluation II score, intubation and intensive care unit stay durations, discharge status and complications were examined. Results: The mean patient age was 78.6±7.4 years, and the mean Acute Physiology and Chronic Health Evaluation II score was 27.0±5.9. Tracheotomy was performed after a mean duration of 34.8±17 days, and the mean intensive care unit stay duration was 94±54 days. Major and minor haemorrhage were observed in 1 (1.4%) and 3 (4.2%) patients, respectively. Total 53 (76%) patients died, 8 (11%) patients were discharged and 9 (13%) patients are still hospitalized. Conclusion: The reluctance of geriatric patients’ relatives to perform tracheotomy affects the time of procedure and duration of intensive care unit stay.Öğe Yoğun Bakım Hastalarında Beslenme İntoleransına Etki Eden Faktörler Ve Mortalite İle İlişkisi: Prospektif Gözlemsel Klinik Araştırma(2020) Şahiner, Yeliz; Doğu, Cihangir; Özçiftci, Serhat; Doğan, Güvenç; Yağan, Özgür; Demir, EmreAmaç: Yoğun bakım hastalarında beslenme büyük bir öneme sahiptir. Hastaların yeterli beslenme desteği alması iyileşme oranlarını artırdığı gibi mortalite ve morbiditeyi de düşürmektedir. Bu çalışmanın amacı hastaların yoğun bakımda beslenme desteği aldığında, hedeflenen kaloriye ulaşmasına engel olan faktörlerini ortaya koymak, varsa beslenme intoleransı ve yetersizliğinin mortalite ve morbitide üzerine etkilerini belirlemektir. Gereç ve Yöntemler: Eylül 2017- Eylül 2018 tarihleri arasında yoğun bakım ünitesine kabul edilen 18 yaş üstü 80 hastanın dâhil edildiği prospektif gözlemsel bir araştırmadır. Seksen hastanın 13’üne sadece parenteral destek verildiğinden çalışma dışı bırakıldı. Hastalar enteral yolla ilk 4 gün hedeflenen kalorinin %50 ve fazlasını alamayan (Grup 1) ve alan (Grup 2) olarak ikiye ayrıldı. Hastaların yaş cinsiyet, boy, kilo, APACHE II, SOFA, Glaskow skorları, yatış nedeni, vazopressör desteği, beslenme desteği, bulantı-kusma, reflü, diyare varlığı, dört günlük kalori ihtiyacına erişimi, solunum desteği, bası yarası, diyaliz gereksinimi, dört günlük kaloriye erişim yolu, ülser proflaksisi, yatış süresi ve mortalite kayıt altına alındı. Bulgular: Grup 1 (n=30) hastada, hedef kaloriye enteral yol ile ulaşılamazken Grup 2 (n=37) hastada enteral beslenmenin yeterli olduğu görüldü. Gruplar arasında yaş, cinsiyet, boy, kilo, VKİ, APACHE II, SOFA ve Glaskow skorları arasında fark olmadığı tespit edildi. Hastaların %80.5 (n=54) mekanik ventilatör desteği, %12.9 (n=7) trakeostomi ile destek aldığı görüldü. Mekanik ventilatör desteği almayan hastalarda %19.5 (n=13) hastanın noninvaziv ventilatasyon desteği aldığı görüldü. Solunum desteği açısından gruplar arasında anlamlı fark saptanmadı. Hastaların kültürde üreme, vazopressör desteği, mortalite ve yatış süresi açısından anlamlı fark saptanmadı. Sonuç: Hastaların iyileşme sürecine katkıda bulunmak için beslenme büyük önem arz eder. Bu çalışmada da enteral beslenmenin, beslenme intoleransı ve yetersizliğine yol açmayacak şekilde hastanın gereksinimi olan enerji ihtiyacına ek morbidite eklemeden ulaşmasına yardımcı olduğu görülmüştür. Beslenme intoleransı hakkında yapılan çalışmalarda mortalite ile ilişkilendirilse de çalışmanın sonuçlarında mortalite ve yoğun bakım yatış süreleri ile beslenme intoleransı arasında ilişki bulunmamıştır.
