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Öğe Çankırı yöresinde deri biyopsilerinin değerlendirilmesi: İki yıllık retrospektif bir değerlendirme(Türk Dermatoloji Derneği, 2014) Şenel, Engin; Yuyucu Karabulut, Yasemin; Karabulut, Hacı Halil; Dölek, Yasemin; Kurşun, NazmiyeAmaç: Epidemiyolojik çalışmalar, sağlık sorunlarının önlenmesi ve çözümlenmesinde önemlidir. Bu çalışmayı, Çankırı yöresindeki deri biyopsilerini değerlendirmek amacıyla gerçekleştirdik. Yöntem: Ocak 2011 ve Ocak 2013 tarihleri arasında Deri ve Zührevi Hastalıkları Polikliniği’ne başvuran 2128 hasta ve 2128 lezyon retrospektif olarak incelendi. Hastaların demografik özellikleri, lezyon lokalizasyonları ve tipleri dermatoloji ve patoloji kayıtlarından istatistik inceleme için alındı. Patoloji preparatları retrospektif olarak tekrar incelendi ve konulan tanılar teyit edildi. Bulgular: En sık görülen tümör tanısı melanositik nevüstü (%27, n=574) ve bu tanıyı kistik tümörler, soft fibrom/akrokordon ve psoriasis izliyordu. Genel olarak en sık tümör lokalizasyonu yanak ve dudak olarak saptandı (%21,7). En genç hasta popülasyonunu molluskum kontagiozumlu hastalar oluştururken (25,00±11,04 yaş), en yaşlı hasta grubunda yassı hücreli karsinom (YHK)’lı hastalar bulunmaktaydı (71,69±12,79 yaş). En sık görülen malign deri tümörü bazal hücreli karsinom (BHK) olarak saptandı (n=92, %74). BHK’ler en sık olarak burun lokalizasyonunda yerleşmişlerdi (%35,9). İkinci en sık malign deri tümörü ise YHK olarak saptandı (n=32, %26). İki malign tümör grubu olan BHK ve YHK grupları arasında yaş açısından istatistiksel olarak farklılık mevcut değildi. Sonuç: Çankırı Yöresinde malign deri tümör oranları literatürle uyumludur. Epidemiyolojik araştırmalardaki artış, diğer çalışmalarla karşılaştırma imkanı sağlayabilir ve sağlık yönetimi planlamalarını kolaylaştırabilir.Öğe Clinical, histopathological, dermatoscopic and digital microscopic features of dermatofibroma: A retrospective analysis of 200 lesions(Blackwell Publishing Ltd, 2015) Şenel, Engin; Yuyucu Karabulut, Yasemin; Doğruer Şenel, SeherBackground Dermatology literature lacks a study investigating both histopathological and dermatoscopic features of dermatofibroma. Objective To analyse histopathological, dermatoscopic and digital microscopic features of dermatofibromas. Methods Two hundred dermatofibromas and 190 patients were included and retrospectively evaluated. Nine histopathological and ten dermatoscopic patterns were used to classify the lesions. We identified four different types of dermatofibroma in digital microscopy. Results The mean age of the patients was 42.18 ± 13.72 years. Dermatofibroma was more common in females (67%) and the male to female ratio was 1: 1.97. The most common location was leg (41%). The most frequent histopathological variant was fibrocollagenous type (49%). Grenz zone was the most common histopathological finding (89%). The most frequent digital microscopic type was type 1 (63%). Conclusions We found that palisading variant displayed only pattern 6 in dermatoscopy and cellular variant showed type 3 significantly in digital microscopy. © 2015 European Academy of Dermatology and Venereology.Öğe Doksisiklin tedavisinin neden olduğu özofajit(Turkish Society of Hematology, 2016) Şenel, Engin; Topal, Firdevs; Mansuroğlu, Cem; Yuyucu Karabulut, YaseminÖzofajit, özofagusun en yaygın hastalığıdır. İlaç kullanımı, kimyasal özofajit nedenlerinden biridir. Burada akne tedavisinde doksisiklin kullanımı nedeniyle özofajit gelişen 17 ve 18 yaşlarında iki erkek hasta sunuyoruz. Her iki olgu da yaklaşık bir haftadır doksisiklin kullanmaktaydı. On yedi yaşındaki olguda özofagus üst ve orta kesimde ülserasyonlar saptandı. On sekiz yaşındaki olguda ise özofagus orta kısımda sirküler ülserasyonlar mevcuttu. Doksisiklinin neden olduğu özofajit, hekimin hastayı ilaç alımı konusunda yeterince bilgilendirmesiyle önlenebilen bir durumdur.Öğe Frequency and etiology of chondrodermatitis nodularis chronica helicis(2013) Yuyucu Karabulut, Yasemin; Şenel, Engin; Dölek, YaseminObjectives: Chondrodermatitis nodularis chronica helicis (CNH) is a painful nodule affecting the pinna. The etiology of the disease is unknown. We devised to show a correlation between CNH and systemic health problems of the patients. Materials and Methods: This study included 17 patients with CNH and the other lesions of the ear that incoming differential diagnoses of CNH, including basal cell carcinoma, squamous cell carcinoma, verruca vulgaris, neurofibroma, fibroepithelial polyp, seborrheic ceratose, and cystic lesions, a total of 131 patients that were diagnosed between 2011 and 2012 in the Clinics of Dermatology and Pathology of Çankr State Hospital. Cardiovascular problems of the patients were queried meticulously and recorded. Results: With 17 patients 12.97% of the 131 patients were CNH. The mean age of the patients was 47.41 and the age range of the CNH patients was 32-79 years, with a mean age of 54.9 years (SD ± 13.23 years). The mean diameter of the lesions was 4.57 mm for CNH patients. The lesions were located at the right air mostly (85.71%) and all of them were located at the helix of ear. The laboratory results of the CNH patients showed that most of them (88.2%, 15 patients) have high cholesterol and lipid levels. By the way six of them (35.2%) also had cardiac problems. Conclusion: Our results showed that the main problem is the defect of arterial blood supply of the pinna. Also we detected that12.97% of the lesions were CNH, while cystic lesions take the first place among all other ear lesions.Öğe Gingival pyogenic granuloma developing during isotretinoin treatment(Deri Zuhrevi Hastaliklar Dernegi, 2014) Şenel, Engin; Kargın Kaytez, Selda; Yuyucu Karabulut, YaseminPyogenic granuloma (PG) is a rare side effect of isotretinoin therapy. Oral pyogenic granuloma developing during isotretinoin treatment has not been reported so far. A 22-old-male patient, who had been given oral isotretinoin treatment for severe nodular acne, was admitted with the complaint of a painless and red nodule in his lower gum at the end of the second month of the treatment. The patient did not report any history of trauma or dental treatment. Dermatologic examination revealed a hemorrhagic nodule measuring 1.5x1 cm in size in the lower gums of the cutting and canine teeth. The lesion was excised completely. Histopathological examination disclosed acanthosis and hyperkeratosis in epidermis, subepidermal vascular proliferation, edema, and sparsely scattered inflammatory cell groups. The mechanism by which isotretinoin causes pyogenic granulomas is not exactly known. It should be considered that this rare side effect can be gingival in patients taking isotretinoin and the regular oral examination should not be neglected.Öğe Göz kapağı tümörlerinin histopatolojik ve demografk özellikleri(Türk Dermatoloji Derneği, 2014) Karabulut, Hacı Halil; Yuyucu Karabulut, Yasemin; Şenel, Engin; Dölek, Yasemin; Uslu, Asım; Kurşun, NazmiyeAmaç: Göz kapağının benign ve malign lezyonlarının klinik, histopatolojik ve demografik özelliklerini değerlendirmek. Yöntemler: Çalışmamızda 2011-2013 tarihleri arasında hastanemiz Deri ve Zührevi Hastalıklar, Göz Hastalıkları ve Plastik Cerrahi Klinikleri’nde, göz kapağında kitle nedeni ile opere edilen hastaların kayıtları geriye dönük olarak değerlendirildi. Bulgular: Çalışmaya yaş ortalamaları 45 yıl olan (4-85 yıl), 54 (%40,9) erkek, 78 (%59,1) kadın toplam 132 hasta dahil edildi. Tümör lokalizasyonu 74 (%56,1) hastada üst kapak, 58 (%43,9) hastada alt kapak idi. Malign kapak tümörleri, yaş ortalamaları 68,12 yıl olan 8 (%6,1) olguda izlenirken, 3 olguda skuamöz hücreli karsinom, 5 olguda bazal hücreli karsinom tespit edildi. Benign tümörler yaş ortalamaları 43,18 yıl olan 24 olguda izlendi. En sık görülen kapak tümörü 39 (%29,5) olguyla melanositik dermal nevüs idi. Fibroepitelyal polip 36 (%27,3) olguda, ksantelezma 23 (%17,4) olguda, epidermal inklüzyon kisti 14 (%10,6) olguda ve seboreik keratoz 12 (%9) olguda izlendi. Kadınlarda en sık gözlenen tümör melanositik dermal nevüs iken (%34,61), erkeklerde en sık fibroepitelyal polip (%35,18) izlendi. Sonuç: Çalışmamızda kapaklarda en sık gözlenen benign tümör melanositik nevüs iken, en sık malign tümör bazal hücreli karsinom olarak saptandı. Kapak tümörleri büyük oranda benign lezyonlar olarak tespit edildi. Benign tümörler 40-50 yaş grubunda sık gözlenirken, malign tümörler 60-70 yaş arasında daha sık gözlendi.Öğe Idiopathic scrotal calcinosis: The incorrect terminology of scrotal calcinosis(Edizioni Minerva Medica, 2015) Yuyucu Karabulut, Yasemin; Kankaya, Duygu; Şenel, Engin; Dölek, Yasemin; Uslu, Asım; Sertçelik, AyşeAim. Scrotal calcinosis is a rare and benign condition characterized by multiple calcific deposits occurring in scrotum and formed as nodules and lumps within scrotal skin with any systemic metabolic disorder. The so-called idiopathic scrotal calcinosis does not appear to be idiopathic, but rather a process of dystrophic calcification of epidermal cysts. Histological examination shows calcium deposites with in the dermis that may be surrounded with histiocytes and an inflammatory giant cell reaction. The aim of this paper was to detect dystrophic calcification of epidermal cysts and to take attention to the incorrect terminology of "idiopathic calsification". Methods. This is a two-centered study of scrotal calcinosis with 17 cases, on which clinical and histopathological examinations were conducted. Results. The patients we examined all had scrotal epidermoid cysts in varying stages of inflammation coexisted with scrotal calcinosis. Some cyts (52.9%) had intact epithelial walls, others (35.2%) showed rupture of their epithelial walls associated with the presence of keratin fibers and calcium granules in the surrounding dermis and all had naked calcium deposits lying in the dermis. Conclusion. The spectrum of the changes that we experienced in the histology, coupled with the normal values in the biochemical profile, shore up the theory of dystrophic calcification of epithelial cysts. During the time first these cysts become inflamed than rupture in the and calcium depocytes replase with the cysts.Öğe Three different clinical faces of the same histopathological entity: Hair follicle nevus, trichofolliculoma and accessory tragus(Sociedade Brasileira de Dermatologia, 2015) Yuyucu Karabulut, Yasemin; Şenel, Engin; Karabulut, Hacı Halil; Dölek, YaseminBACKGROUND: Hair follicle nevus is a rare, congenital hamartoma with follicular differentiation characterized histologically by numerous, tiny, mature hair follicles. Trichofolliculoma, the histopathological features of which are quite similar to those of hair follicle nevus, is also a hamartoma that differs from hair follicle. Accessory tragus is a relatively common, benign congenital abnormality of the external ear with an incidence rate of 1 to 10 per 1,000 live births. OBJECTIVE: This study seeks to assess the discriminatory value of currently available, histological criteria in the differential diagnosis of hair follicle nevus, accessory tragi and trichofolliculoma. METHODS: Twenty-one patients comprising 9 cases of hair follicle nevus, 8 accessory tragi patients and 4 trichofolliculoma cases, were recruited to perform the study. RESULTS: There were 10 males and 11 females in the study group. No significant difference was observed between the three study groups in terms of age, gender or histopathological parameters such as density of hair follicles, subcutaneous fat score and presence of connective tissue framework. Cartilaginous component was seen in 8 cases that were diagnosed as accessory tragi, while central cyst and radiating hair follicles were seen in 4 cases which were diagnosed as trichofolliculoma. CONCLUSION: The results of our study showed that diagnostic discrimination of these diseases could be made only with the clinicopathologic correlation because of their clinical and histopathological similarities. © 2015 by Anais Brasileiros de Dermatologia.Öğe Two large nodules on the scalp of a 60-year-old woman(Blackwell Publishing Ltd, 2015) Yuyucu Karabulut, Yasemin; Şenel, EnginA 60?year?old woman presented with a 2?year history of two large nodules on her head. She also reported a 1?year history of intermittent mild headache. On physical examination, two nodules were seen, located on the occipital region of the patient's head.Öğe Yirmi yaşında erkek hastada çok sayıda asemptomatik skrotal nodüller(Marmara University, 2015) Yuyucu Karabulut, Yasemin; Şenel, Engin; Uslu, AsımYirmi yaşındaki erkek hasta yaklaşık on yıldır skrotumunda mevcut olan ağrısız şişlikler nedeniyle Deri ve Zührevi Hastalıklar polikliniğine başvurdu. Dermatolojik incelemede skrotumda çok sayıda, iyi sınırlı, hassas olmayan, sert subkutan nodüller gözlendi.
