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Do We Know the Long-Term Effects of the Most PopularTraditional Swallow Maneuvers on the Submental Muscles?
(WILEY, 2024) Söyler, Ayşe Kübra; Kıylıoğlu, Nefati; Arslan, Selen Serel; Demir, Numan; Gök, Mustafa; Ertekin, Ersen; Düger, Tülin
Background: Various trainings focus on the submental muscles (SMs) for dysphagia rehabilitation because of their importancefor swallowing safety and efficiency. According to the current literature, swallow-specific tasks may be optimal exercises fordysphagia. The effortful swallow (ES) and the Masako maneuver (MM) are the most commonly used swallow-specific tasks inthe clinical settings for dysphagia for years, but long-term effects for these trainings is insufficient.Objectives: This study aims to investigate and compare the effects of ES and MM on SM activity, strength and thickness.Methods: Thirty-seven healthy adults were randomised to ES, MM and control groups, and ES and MM groups completed6 weeks of swallowing training. Participants in both training groups performed a total of 120 swallows in each session, whilecontrol group did not participate in any swallowing training. Surface electromyography was used to evaluate SM activity, digitaldynamometer for SM strength and ultrasonography for SM thickness.Results: Both trainings did not change SM activity (p > 0.05), but increased SM strength (p < 0.05). MM increased the thicknessof all SM (p < 0.05), and ES increased the thickness of mylohyoid (right, left) and digastric muscle (right) (p < 0.05), and therewas no change in all evaluation parameters in the control group (p > 0.05). Also, trainings were not superior to each other in anyparameter (p > 0.05).Conclusion: The results of this study provided new evidence to the literature to show that ES and MM trainings are effectivefor improving SM strength and thickness. Considering that SM is important in terms of swallowing safety and effectiveness, it isthought that both trainings may be promising by increasing the strength and mass of SM, especially in individuals with reducedSM strength and mass.
Heart Failure Awareness Survey in a Turkish Population: HFAS-TR
(KARE PUBL, 2024) Karabulut, Dilay; Günay, Şeyda; Sert Şekerci, Sena; Bekar, Lütfü
Objective: Heart failure is a leading cause of death and the most common diagnosis leading to hospitalization. Its awareness is lower than that of other cardiovascular diseases, both in the general population and among patients with heart failure (HF). This study aimed to establish the current level of knowledge about HF in patients with HF with reduced ejection fraction (HFrEF) and mildly reduced ejection fraction (HFmrEF) in Türkiye. Methods: This questionnaire-based survey study is multicenter, conducted across 34 centers from December 2021 to July 2022. We performed a survey consisting of two sets of questions focusing on individual characteristics of the patients and HF-related knowledge. Results: The study included a total of 2,307 outpatient HF patients, comprising 70.5% males and 29.5% females with a mean age of 64.58 ± 13 (56-74) years and a mean body mass index value of 32.5 ± 10 kg/m2. HFrEF and HFmrEF were determined in 74.7% and 25.3% of patients, respectively. Thirty percent of the patients were unaware that they had HF. While 28.7% of the patients thought that they had sufficient information about HF, 71.3% believed they lacked adequate knowledge. In the study, 25.2% of the participants identified dyspnea, 22% identified tiredness, and 25.4% identified leg edema as the most common symptoms of HF. Only 27.4% of patients recognized all three typical symptoms of HF. Conclusion: We found that the study population’s knowledge about HF symptoms and the nature of the disease was poor. Educational and awareness activities are necessary to optimize outcomes and benefits.
Service Quality and Related Factors in Primary Health Care Services: A Cross-Sectional Study
(MDPI, 2024) Değer, Mehmet Sait; Issever, Halim
Primary health care services aim to prevent diseases and improve health efficiently and effectively. This study measures perceived service quality in a primary healthcare organization and examines the effect of personality traits on service quality. The cross-sectional study population comprised individuals over the age of 18 who applied to the Bing & ouml;l Central Community Health Centre. A total of 460 participants were included in the study between November 2018 and March 2019. The participants completed a face-to-face questionnaire that included socio-demographic characteristics, the SERVQUAL Scale, and an abbreviated form of the revised Eysenck Personality Questionnaire. This study is based on doctoral research in public health. The study found median values for personality trait sub-dimensions as follows: neuroticism: 2, psychoticism: 2.65, extraversion: 4, and lying: 5. The SERVQUAL Score was -0.02. The study revealed that the quality of primary health care services did not meet the participants' expectations. The study findings also indicated that age, educational attainment, and extraverted and psychotic personality traits were significantly associated with the satisfaction of service quality expectations (p < 0.05). It is recommended to provide primary health care services in facilities with good physical characteristics, with sufficient and competent health personnel, and in a timely and accurate manner to improve service quality.
Assessment of frailty, daily life activities, and nutrition of elderly immigrants: A household based cross-sectional study
(LIPPINCOTT WILLIAMS & WILKINS, 2024) Değer, Mehmet Sait; Sezerol, Mehmet Akif; Atak, Muhammed
With the global migrant population on the rise, it's imperative to focus on the health status of more vulnerable groups within these communities. The elderly immigrants face myriad physical and psychosocial challenges that significantly impact their health and quality of life. This study aims to investigate the nutrition, daily life activities, and clinical frailty status of elderly immigrants residing in T & uuml;rkiye. A cross-sectional design was employed in the Sultanbeyli District, focusing on Syrian immigrants aged 65 and over. Participants were surveyed face-to-face by interpreters proficient in Arabic. The questionnaire comprised sociodemographic details, health status, and scales like Katz Daily Life Activities, Clinical Frailty, and Mini Nutritional Assessment. The data analysis was executed using SPSS 22. Continuous variables were presented as mean +/- standard deviation (SD) and median, while categorical ones were expressed in numbers and percentages (%). A significance level of P < .05 was considered for the analyses. The average age of the participants was determined as 71.64 +/- 6.20 years. In the study group, 49.7% were female, 75.5% were younger than 75 years old, 47.7% had less than primary school education, 56.3% were married, 42.4% had a low income level, and 56.9% lived in the same household with 5 or more people. Among the participants in the study group, 47% had walking and balance problems, 29.1% had a history of falls in the last year, 10.6% were disabled, 69.5% complained of pain, 82.8% had a chronic illness, and 43% had polypharmacy. The median value of the KATZ Daily Living Activities scale was 6, the mean score of the Clinical Frailty Score scale was 3.25 +/- 1.25, and the mean score of the Mini Nutritional Assessment scale was 12.40 +/- 2.15. Among immigrant elderly individuals, 88.1% were able to sustain their lives independently, 13.9% were clinically frail, and 3.3% were at risk of malnutrition. Factors such as age, level of education, socioeconomic status, marital status, number of cohabitants in the household, BMI, neurological problems, walking-balance disorders, disability, and presence of chronic diseases are associated with daily life activities, frailty, and malnutrition status. It is believed that broader field research with greater participation would be beneficial for evaluating the nutritional status of immigrant elderly individuals.
Investigation of the relationship between ACAN geneVNTR polymorphism and Alzheimer’s disease inTurkish population
(TAYLOR & FRANCIS INC, 2024) Keskin, Tuğba; Avşar, Orçun; Eliaçık, Sinan; Uysal Tan, Funda
Alzheimer’s disease is one of the most common causes of dementia and is a neurodegenerative disease that occurs with memory loss, loss of language, thinking and problem-solving skills. In this study, it was aimed to reveal the relationship between Alzheimer’s disease and the variable number tandem repeat (VNTR) polymorphism in the aggrecan (ACAN) gene. Thus, it is thought that it will contribute to enlightenment about disease by contributing to the pathophysiology of Alzheimer’s disease. A total of 203 people, including 102 patients diagnosed with Alzheimer’s and 101 healthy individuals, were included in the study. Deoxyribonucleic acid (DNA) extraction was performed from the blood samples taken. The variable number tandem repeat (VNTR) polymorphism of the ACAN gene was determined using the Polymerase Chain Reaction (PCR) method. In our study, the 30?R, 31?R and 33?R alleles were the most repetitive alleles in patients and controls. 30?R, 31?R and shorter alleles were more common in patients than in the control group and were found to be statistically significant (p?=?0.042). According to our results, 30?R and 31?R alleles of the VNTR polymorphism in the ACAN gene may be associated with Alzheimer’s disease. In addition, having less than 30 repeat alleles increases the risk of the disease by 2,202 times. Our study is the first to investigate the relationship between ACAN gene VNTR polymorphism and Alzheimer’s disease. Further studies are needed to definitively relate it.
Association between Alzheimer’s disease, MAPT genemutation and some biochemical biomarkers
(TAYLOR & FRANCIS INC, 2024) Şen, Ayşenur; Avşar, Orçun; Eliaçık, Sinan; Uysal Tan, Funda
Alzheimer’s Disease (AD) is a multifactorial neurodegenerativedisease and there is still no definitive treatment today. Earlydiagnosis of the disease is important, but there are almost nobiomarkers that can be used in early diagnosis. The cerebro-spinal fluid used in the diagnosis of the disease is not suffi-cient and is very difficult to obtain. Therefore, blood biomarkersthat are less costly, less invasive, easily accessible, and can beused in long-term studies would be a better alternative. Theaim of this study is to determine the relationship betweenAlzheimer’s Disease and P301L MAPT gene mutation, homo-cysteine, folate and uric acid. 101 Alzheimer’s patients and101 healthy individuals were included in this study. Mutationanalysis was performed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) methodwith blood samples taken from the subjects. There was nosignificant difference between the patient and control groupsin terms of homocysteine (p = 0.771), folate (p = 0.366) and uricacid (p = 0.860). When the genotypes were compared betweenthe patient and control groups in terms of MAPT gene muta-tion (P301L), no statistically significant difference was detected(p = 0.081). There are very few studies in the literature investi-gating the relationship between Alzheimer’s disease and P301LMAPT gene mutation. Additionally, there is no study investigat-ing the relationship between Alzheimer’s disease and homocys-teine, folate, uric acid and P301L MAPT mutation in the Turkishpopulation. We believe that this study has shed light on futurestudies.
Vortioxetine treatment for neuropathic pain in major depressive disorder: a three-month prospective study
(FRONTIERS MEDIA SA, 2024) Eliaçık, Sinan; Erdoğan Kaya, Ayşe
Introduction and objective: Several studies revealed the therapeutic potential of vortioxetine (Vo) for pain. In this context, we aimed to evaluate the efficacy of Vo as a safe and tolerable novel pharmacologic agent in treating neuropathic pain (NP) in patients with major depressive disorder (MDD). Materials and methods: The population of this cross-sectional prospective study consisted of all consecutive patients who were newly diagnosed with MDD by a neurology doctor at a psychiatric clinic and had NP for at least 6? months. All patients included in the sample were started on Vo treatment at 10? mg/ day. They were assessed with Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Self-Reported Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS), Douleur Neuropathique 4 Questions (DN4), Montreal Cognitive Assessment (MoCA), and Neuropathic Pain Impact on Quality of Life (NePIQoL) at the beginning of treatment and during the follow visits conducted at the end of the first, second and third months of the treatment. During these follow-up visits, patients were also queried about any side effects of Vo. Results: The mean age of 50 patients included in the sample, 76% of whom were female, was 45.8? ±? 11.2? years. There was a significant reduction in patients’ NP complaints based on DN4 and S-LANNS, the subscales of NePIQoL, and significant improvement in MoCA. There was a significant reduction in patients’ NP complaints based on DN4 and S-LANNS scores and a significant improvement in scores of the subscales of NePIQoL and MoCA. Conclusion: The study’s findings indicate that Vo, with its multiple mechanisms of action, can effectively treat NP independently of its mood-stabilizing effect. Future indication studies for Vo are needed to establish Vo’s efficacy in treating NP.
Global Publication Trends and Research Hotspots of the Gastric Neuroendocrine Neoplasms: A Bibliometric Analysis of the Current Situation
(Pera Yayincilik Hizmetleri, 2024) Köseoğlu, Hüseyin; Kaya, Muhammed; Durak, İbrahim; Düzenli, Tolga; Kaymazlı, Mustafa; Sezikli, Mesut
Objective: Gastric neuroendocrine neoplasms (gNENs) are uncommon tumors, with growing understandings about the disease. Bibliometric analyzes have the advantage of visually depicting the dynamic evaluation of scientific knowledge of a specific topic. The aim of this study was to perform and report bibliometric analysis of gNENs, which was not formerly studied in the literature. Methods: Articles published between 1980 and 2022 within the database of Web of Science Core Collection were included in this bibliometric analysis. Vosviewer package program and Datawrapper were used for bibliometric data interpretation. Results: A total of 2270 articles about gNENs was detected with 63240 citations and an H index of 103. A remarkable increase was detected among the articles for years. Research have focused on gastroenterology and hepatology, endocrinology and metabolism, oncology, general medicine, pathology and surgery areas. Norwegian University of Science Technology was the leading institution about gNENs literature. Modlin IM, had the highest number of articles and citations among the authors. United States, Japan and Italy were the top three countries with the most published articles. Conclusion: This bibliometric study provides an engrossing, insightful conclusion to the research and development trajectory in gNENs with a future perspective.
Images Download Cite Share Favorites Permissions Research Article: Observational Study The evolution of Pemphigus publications: A bibliometric analysis with research trends and global productivity
(LIPPINCOTT WILLIAMS & WILKINS, 2024) Öztekin, Aynure; Öztekin, Coşkun
Despite an increase in global research on the subject of Pemphigus, which seriously affects patient health and quality of life, there is no bibliometric research on this subject in literature to date. The aim of this study was to conduct a holistic analysis of scientific articles published on Pemphigus, using bibliometric methods. Articles published on the subject of Pemphigus between 1980 and 2021 were downloaded from the web of science (WoS) database and analyzed using various statistical methods. To determine trend subjects, collaboration between countries, and the most effective studies with citation analyses, visual network maps were obtained with bibliometric analyses. A total of 3034 articles were analyzed. The 3 countries making the greatest contribution to literature were the USA (n:831, 27.3%), Japan (n:402, 13.2%), and Germany (n:221, 7.2%). The 3 most active institutions were Keio University (n:163, 5.3%), Kurume University (n:130, 4.2%) and Tel Aviv University (n:107, 3.5%). The 3 journals publishing the most articles were the British Journal of Dermatology (n: 88), Journal of the American Academy of Dermatology (n:171) and the Journal of Investigative Dermatology (n:143). The 3 leading journals according to the mean number of citations (NC) per article (citation count: CC) were the New England Journal of Medicine (CC:246), the Lancet (CC:143) and the Journal of Cell Biology (CC:133). The author with the most articles published was Hashimoto Takashi (n.168, 5.5%). As a result of cluster analysis, it was seen that 9 different main clusters had been studied on Pemphigus subjects to date (1: desmoglein, 2: paraneoplastic Pemphigus (PNP) – Pemphigus types-desmosome, 3: desmoglein 1 ve 3-autoimmunity, 4: treatment-rituximab, 5: acantholysis-apoptosis, 6: quality of life-remission-relapse, 7: autoantibodies, 8: epidemiology-mortality, 9: corticosteroids). The most commonly studied subjects were determined to be pemphigus vulgaris (PV), pemphigus foliaceus (PF), autoimmunity, rituximab, PNP, desmoglein (desmoglein3-desmoglein1), autoantibodies, acantholysis, autoantibody, treatment, autoimmune disease, desmosome, ELISA, and immunofluorescence. The primary trending topic was rituximab drug, which is used in the treatment of Pemphigus. The other most studied trend topics were azathioprine drug used in treatment, intravenous immunoglobulin treatment, quality of life, mortality rates, Pemphigus herpetiformis, and wound healing. Abbreviations: AC = average citation per article, CC = citation count, CI = confidence interval, GDP = gross domestic product, HDI = human development index, NC = number of citations, PF = pemphigus foliaceus, PNP = paraneoplastic Pemphigus, PV = pemphigus vulgaris, UK = United Kingdom, USA = United States of America, WoS = web of science.
Smokers Versus Non-Smokers: Comparing Cognitive Flexibility and Dyspnea Symptoms in Medical Students
(Pera Yayincilik Hizmetleri, 2024) Erdoğan Kaya, Ayşe; Durak, Büşra
Objective: Smoking is an escalating public health concern globally, notably for its frequency among young individuals and the medical conditions it induces. This research aims to explore the association between smoking and the symptoms of dyspnea as well as cognitive flexibility levels in medical students. Methods: This cross-sectional study included 188 volunteer medical school students. Participants were administered a sociodemographic data form, the Dyspnea-12 Scale, and the Cognitive Flexibility Scale. The participants were divided into two groups as smokers and non-smokers and compared in terms of the applied scale scores. The data were analyzed using the appropriate statistical methods with IBM SPSS v.22 software. Results: Of the 188 participants, 56.9% (n:107) were female, while 43.1% (n: 81) were male. The prevalence of smoking among participants was 26.1% (n: 49), with rates at 38.3% (n:31) for males and 16.8% (n: 18) for females. The smoking rate was significantly higher in males (p<0.001). No significant difference was detected between smokers and non-smokers regarding the Dyspnea-12 score. However, the Cognitive Flexibility Scale scores were significantly lower in the smoker group (p:0.018). Conclusion: In our study, we found that the smoking rate among medical students was quite high and that smoking negatively affected cognitive flexibility. It may be beneficial to consider this when evaluating cognitive functions in educated individuals who smoke.
The Charlson Comorbidity Index Predicts Poor Prognosis in Elderly AML Patients
(AKAD DOKTORLAR YAYINEVI, 2023) Tığlıoğlu, Mesut; Albayrak, Murat; Tığlıoğlu, Pınar; Yıldız, Abdulkerim; Doğan, Servihan; Afacan Öztürk, Hacer Berna; Maral, Senem; Sağlam, Buğra; Aras, Merih Reis; Dilek, İmdat
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults and patients older than 65 years have a poor prognosis. Patient-related factors, such as comorbid conditions that affect performance status, and insufficient organ functions, explain why elderly patients have a worse prognosis. The Charlson Comorbidity Index (CCI), is used to predict prognosis according to comorbidities. This retrospective study was conducted on patients diagnosed with AML between 2010 and 2019. Patients >60 years were included. Demographic information, comorbidities, CCI, ECOG ( Eastern Cooperative Oncology Group) score, cytogenetic characteristics, treatment regimens, treatment response, follow-up periods were recorded for all patients. Evaluation was made of a total of 82 patients with a mean age of 71.18 ± 7.67. The median follow-up was 6.7 months. The median number of comorbidities was 1 [0.0-4.0] with the median CCI score of 3 [2.0-6.0]. Median overall survival (OS) was 7.0 months [3.1-10.8] and PFS was 6.8 months [3.6-10.0]. As the median CCI score was 3, patients were divided into two groups as CCI > 3 and CCI ? 3. Age, gender, ECOG, cytogenetic risk profile, first-line treatment and CR1 achievement status were all similar in both groups (p > 0.05). Patients with CCI > 3 had significantly shorter OS than patients with CCI ? 3 (3.6 months [0.3-29.3] vs 8.6 months [0.2-60.2], p= 0.049). The results of the current study demonstrated that CCI, can be used as a prognostic index in elderly patients with AML independently of other patient and disease-related characteristics.
Platelet inventory and using out-of-group platelet suspension: A cost-effective strategy for a blood transfusion service
(King Faisal Specialist Hospital and Research Centre, 2023) Yıldız, Abdulkerim; Doğan, Murat; Yalvaç, Mehmet; Zihar, Bilge
Background: Platelet (PLT) transfusions are essential for advanced hospitals, especially those with onco-hematology departments. However, platelet concentrates (PCs) have supply limitations and a shorter shelf life, which create difficulties for blood transfusion services (TSs). Materials and methods: This retrospective study was conducted over a 4-year period between January 2017 and January 2021 in a tertiary referral hospital. From the beginning of 2020, as a new strategy of our TS, a PLT inventory was produced and ABO-identical transfusions were prioritized when the inventory allowed; when this was not possible, ABO and Rh incompatible transfusion was employed. The numbers of transfused and discarded PCs were compared for each year. Results: In 2017, a total of 799 PPCs were used and 70 PPCs were discarded with the expiration ratio (ER) of 8.0%. In 2018, 1124 PPCs were used and 99 PPCs were discarded with the ER of 7.4%. In 2019, 726 PPCs were used and 91 PPCs were discarded with the ER of 11.1%. In 2020, 1100 PPCs were used for 569 patients, of which 251 PPCs were ABO and Rh incompatible without any severe transfusion reaction. A total of 56 PPCs were discarded with the ER of 4.8%. Conclusion: The results of the current study suggested that with the determination of the platelet stock level and the use of out-of-group PCs, the rate of discarded PLT could be reduced. Nevertheless, based on current literature and experience, each TSs should make their own strategies and policies to provide an adequate supply of PCs.
The Utility of CONUT Score in Indolent Lymphoma Patients
(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2023) Tığlıoğlu, Mesut; Afacan Öztürk, Hacer Berna; Yıldız, Abdulkerim; Tığlıoğlu, Pınar; Yılmaz, Fatma; Aras, Merih Reis; Albayrak, Meryem
Background and Aim: Similar to the uncertainties in the treatment criteria for indolent non-Hodgkin lymphoma (iNHL), the prognostic criteria have not been fully clarified. The Controlled Nutritional Status (CONUT) score is not only used as a predictor of malnutrition but also indicates prognosis in many chronic or malignant diseases. The aim of this study is to investigate the predictive and prognostic significance of the CONUT score in patients with iNHL. Patients and Methods: A retrospective evaluation was made of 109 patients with iNHL. The CONUT scores of the patients were compared between those with an indication for treatment and those followed without treatment. The same analysis was performed between patients who developed relapse after treatment. Survival analysis was performed on all patients, and associations between survival and the CONUT score were examined. Results: The median CONUT score was found to be higher in those who had treatment indications compared to those who did not (2 vs 1; P = 0.014). In the regression model, a CONUT absolute value above 5 was found as an independent risk factor predicting relapse. In the whole study population, a CONUT absolute value >2 predicted the risk of mortality with 53.9% sensitivity and 68.7% specificity (AUC ± SE = 0.639 ± 0.07; +PV = 35%; -PV = 82.6%; P = 0.034). Conclusion: CONUT score is a predictive and prognostic factor for patients with iNHL. The development of simple, low-budget prognostic and predictive biomarkers is critical not only for determining the course of the disease but also for follow-up and treatment management.
Current practice of emergency radiology in Turkey and future expectations: a survey study
(GALENOS PUBL HOUSE, 2023) Tunçyürek, Özüm; Onur, Mehmet Nuri; Ertekin, Ersen; Çallı, Cem
PURPOSE The development of emergency radiology (ER) in Turkey has accelerated with the increase in the number of patients admitted to emergency departments. We aimed to present and discuss the responses to a survey distributed to radiologists in Turkey, which included questions about the current practice of ER and future expectations. METHODS A survey with 29 questions enquiring about the infrastructure of respondents’ hospitals and radiology units, information about emergency services and ER (including patient volume), the number of staff and equipment, the ER working plan and reporting method, and training in the field of ER were distributed to members of the Turkish Radiological Society by email. RESULTS The response rate was 21.97% (328/1.493). The presence of distinct ER units in radiology departments was confirmed by 40.55% of respondents, while for 34.25%, ER was located inside the emergency room. Of the respondents, 26.96% stated they believed that emergency cases should be reported by emergency radiologists, and the necessity for an ER subunit in the emergency room was agreed upon by 58.64% of contributors. The majority of respondents (69.54%) agreed with the opinion that residents should receive their ER training in an ER unit. CONCLUSION Keeping abreast of current ER practices and radiologists’ expectations may be helpful for improving national ER practices and academic studies.
The effect of perceived parental attitude score on symptoms of bipolar disorder and schizophrenia
(Prusa Medical Publishing, 2023) Yazla Asaf, Ece; Aydınoğlu, Ünsal; Özalp, Elvan
Objectives: We aimed to investigate the effect of perceived parental attitudes on the symptoms of these diseases in patients with schizophrenia and bipolar disorder (BD) and to compare the perceived parental attitudes between these two disorders. Methods: This cross-sectional study was conducted between August 2020 and August 2021 at a university hospital in Turkey. Fifty-two patients with BD and 50 patients with schizophrenia in remission, aged 16-50 years, who met the respective diagnostic criteria defined by the Diagnostic and Statistical Manual of Mental Disorder-5 were included in the study. Results: The mean age of patients with BD was 38.90±10.95 years, while it was 39.08 ± 11.51 years for those with schizophrenia. Females comprised 65.38% (n = 34) of the BD group and 78.00% (n = 39) of the schizophrenia group. Our results showed that the severity of various negative schizophrenia symptoms increased with higher levels of perceived parental libertarian attitude. In addition, the severity of delusion, which is one of the positive symptoms of schizophrenia, was found to increase with lower perceived parental interest. We did not find a significant relationship between the severity of mania and depression symptoms and perceived parental attitudes. Conclusions: In addition to supporting previously reported relationships of various factors and schizophrenia and BD, our results suggest that the increase in the level of liberality of parents has a negative impact on the negative symptoms of schizophrenia. In addition, the decrease in the level of interest of parents towards their children exacerbates delusion symptoms
Investigation of the Relationship of Serotonin, Dopamine and Their Metabolites with ? – Synuclein in Obsessive Compulsive Disorder
(YERKURE TANITIM & YAYINCILIK HIZMETLERI, 2023) Çetin, İhsan; Kayadibi, Hüseyin; Yazla Asaf, Ece; Aydınoğlu, Ünsal
Objective: Obsessive compulsive disorder (OCD) is a mental disorder characterized by obsessions and/or compulsions. Impulsive features play a role in the etiology, symptomatology and clinical presentation of OCD. ?-synuclein which plays a role in dopaminergic and serotonergic neurotransmission has been shown to be effective in impulse control. The aim of this study was to examine the levels of ?-synuclein, serotonin (5-hydroxytryptamine; 5-HT), dopamine, dopamine ?-hydroxylase (DBH), 5-hydroxyindolacetic acid (5-HIAA), homovanillic acid (HVA) and heat shock protein 70 (HSP70) in OCD. Methods: Twenty-six OCD patients and age-gender matched 23 healthy volunteers were included in this study. Biochemical parameters were analyzed by enzyme-linked immunosorbent assay method. Patients were evaluated with Barratt Impulsivity Scale (BIS) and Dimensional Obsession Compulsion Scale (DOCS). Results: Compared with the controls, significant reduction of 5-HT, dopamine and DBH levels while significant increase of ?-synuclein, HVA and HSP70 levels was found in patients with OCD. Moreover, ?-synuclein levels were significantly negatively correlated with 5-HT, dopamine and DBH, while significantly positively correlated with HVA, 5-HIAA and HSP70. HTR and dopamine levels were found to be associated with the subscale of BIS. Dopamine and DBH levels were found to be associated with the subscale of DOCS. Conclusion: It may be suggested that ?-synuclein is associated with dopaminergic and serotinergic pathways, and may provide important contributions for elucidating the etiology of OCD. It can be suggested that the effect of dopamine is more than 5-HT, based on the fact that not only dopamine but also DBH is correlated with OCD symptoms
Assessing the relationship between antipsychotic drug use and prolidase enzyme activity and oxidative stress in schizophrenia patients: a case-control study
(LIPPINCOTT WILLIAMS & WILKINS, 2023) Yazla Asaf, Ece; Çetin, İhsan; Kayadibi, Hüseyin
Background The relationship between proline, its association with oxidative stress, and its connection to schizophrenia is a subject that has not been sufficiently investigated. Objective The aim of this study is to evaluate the possible effects of atypical and combined (typical and atypical) antipsychotic use on serum prolidase enzyme activity (SPEA) and serum oxidative stress parameters, and to assess the relationship between SPEA and oxidative stress in patients with schizophrenia. Methods A total of 57 patients with schizophrenia, of which 34 were using atypical (AAPG) and 23 were using combined (typical and atypical) (CAPG) antipsychotic therapy, and 28 healthy volunteers (control group) were included in this case-control study. Results SPEA levels of AAPG and CAPG were significantly lower than that of control group (P = 0.003). The oxidative stress index (OSI) value of AAPG was significantly higher than the other two groups (P = 0.001). SPEA (<1860 U/l) and OSI (?0.54) could discriminate schizophrenia patients with antipsychotic therapy from control groups (P = 0.001 and P = 0.007, respectively). Lower SPEA levels were associated with antipsychotic use (P = 0.007). Conclusion The SPEA values of patients with schizophrenia on antipsychotics were significantly lower compared to controls. OSI values were significantly higher in atypical antipsychotic recipients compared to those on combined antipsychotics and healthy controls.
Evaluating a-synuclein, dopamine and serotonin concentrations in the blood of patients with heroin use disorder: Baseline and post-treatment comparisons
(PACINI EDITORE, 2023) Yazla Asaf, Ece; Çetin, İhsan; Kayadibi, Hüseyin
Background. Oligomerization of a-synuclein is induced by serotonin aldehyde, and impulsive behaviour and substance use disorders may be associated with a-synuclein, dopamine and serotonin. Aim: We aimed to compare blood levels of a-synuclein, dopamine and serotonin in patients with heroin use disorder (HUD) and healthy individuals and to assess the possible effects of HUD treatment on the blood levels of these impulsivity-associated markers. Methods: 17 patients with HUD and 23 healthy volunteers were included in this study. All participants' baseline a-synuclein, 5-hydroxytryptamine (5-HT), dopamine, dopamine beta-hydroxylase (D.H), 5-hydroxy indole acetic acid (5-HIAA), homovanillic acid (HVA), and heat shock protein-70 (HSP-70) blood levels were measured. In patients with HUD, levels of these markers were measured after three weeks of buprenorphine treatment. Results: While the pre-and post-treatment HVA levels of the patient group were significantly higher (p=0.036), the pre-and post-treatment D.H (p<0.001), 5-HT (p<0.001) and dopamine (p<0.001) levels were significantly lower compared to controls. The patient group's post-treatment a-synuclein (p=0.044) levels were significantly higher than controls. With a cut-off value of <2000 ng/mL, DBH levels had a sensitivity of 94.1% and a specificity of 100.0% to detect patients with HUD. With a <251 pg/mL cut-off value, dopamine had 94.1% sensitivity and 82.6% specificity in distinguishing patients with HUD from controls. Conclusions: Dopamine and D.H may be helpful markers in diagnosing HUD. Understanding the influence of heroin use on these markers and pathways may enable their utilisation in assessing impulsive behaviour towards heroin.
Factors Associated with the Prevalence of Postpartum Anxiety Disorder and Depression in Syrian Migrant Women Living in Turkey: A Cross-Sectional Study
(MDPI, 2023) Atak, Muhammet; Sezerol, Mehmet Akif; Değer, Mehmet Sait; Kurubal, Hamza
Abstract: The global migration trend has brought attention to the mental health of immigrant populations, especially postpartum women. The prevalence of postpartum anxiety and depression among these populations remains a growing concern. This study aimed to explore the factors associated with postpartum anxiety and depression among immigrant women, with a special emphasis on Syrian migrants in Turkey. A cross-sectional design was employed, enrolling postpartum women who visited the Strengthened Migrant Health Center in Istanbul between July and December 2022. Data were collected using a three-part questionnaire comprising sociodemographic details and scores from the Edinburgh Postpartum Depression Scale (EPDS) and Beck Anxiety Scale (BAI). The average age of participants was 25.73 years. The mean EPDS and BAI scores were low at 1.27 and 3.85, respectively. Notably, 97.1% of women scored below the EPDS cut-off point of 13. EPDS scores showed a significant relationship between income levels and COVID-19 vaccination status, while BAI scores were significantly associated with educational levels. There was an inverse correlation between EPDS scores and the number of cohabitants in a household. The observed low rates of postpartum depression and anxiety could be attributed to the accessible health services and psychosocial support for immigrants in Turkey. It would be useful to conduct multicenter and comprehensive epidemiological studies on migrant puerperas
Cardiovascular evaluation of pregnant women with hypertrophic cardiomyopathy
(URBAN & VOGEL, 2023) Güner, Ahmet; Candan, Özkan; Kahraman, Serkan; Gültekin Güner, Ezgi; Kalçık, Macit
Background: The effect of physiological circulatory changes during pregnancy on hypertrophic cardiomyopathy (HCM) has been reported with limited data. This study aimed to provide information regarding outcomes of pregnant women with HCM and to identify predictors of major adverse cardiac event (MACE). Methods: A total of 45 pregnancies with HCM were retrospectively reviewed. The primary endpoint was a MACE that occurred within an 8-week period after delivery, including maternal death, heart failure (HF), syncope, and malignant ventricular arrhythmias (VAs). Baseline and outcome data were analyzed for all patients. Patients with and without MACE were compared, and patients with obstructive HCM were compared with those who had non-obstructive HCM. The study population was divided into two subgroups of patients having or not having an implantable cardioverter defibrillator implantation (ICD). Results: At least one MACE occurred in 11 patients (24.4%); six patients developed HF (13.3%), six had a ventricular tachyarrhythmia (13.3%), and two had syncope (4.4%). New York Heart Association functional class of ? II, presence of HF signs before pregnancy, increased left ventricular outflow tract (LVOT) gradient were significantly associated with MACE. Fatal VAs were seen during pregnancy in one of five HCM patients with ICD. In the ROC curve analysis, an LVOT gradient higher than 53.5 mm Hg predicted the presence of MACE with a sensitivity of 90.9% and a specificity of 73.5%. This study is the largest series in the literature representing pregnant women who had HCM and ICD. Conclusion: The current data suggest that HF and high LVOT gradients are important risk factors for the development of cardiac complications.

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