Akmeşe, Bediha2021-11-012021-11-0120202149-21232148-4171https://doi.org10.17350/HJSE19030000172https://app.trdizin.gov.tr/makale/TXpZMU9UUXlNZz09https://hdl.handle.net/11491/8176Stress degradation studies control the behavior and impurities of drugs under various stress conditions. The present research is related to all degradation studies including acidic, alkaline, thermal and photo stability on the drug substance according to International Conference on Harmonization (ICH) guidelines. In this study, the degradation profiles of macrolide antibiotics “roxithromycin (ROX), tilmicosin (TIL) and tylosin (TYL)” under varied stress conditions were investigated. The behavior of these drugs under hydrolytic, oxidative, thermal and photolytic conditions were determined by high performance liquid chromatography (HPLC).eninfo:eu-repo/semantics/openAccess[No Keywords]Article71515410.17350/HJSE19030000172