Şanlı, SenemŞanlı, NurullahAlsancak, Güleren2019-05-132019-05-132010Şanlı, S., Şanlı, N., Alsancak, G. (2010). Spectrophotometric determination of acidity constants of some macrolides in acetonitrile-water binary mixtures. Acta Chimica Slovenica, 57(4), 980-987.1318-0207https://hdl.handle.net/11491/1489The acidity constants of eight macrolides (erythromycin, roxithromycin, oleandomycin, azithromycin, josamycin, tylosin tartrate, tilmicosin and spiramycin) have been determined in acetonitrile-water binary mixtures (30%, 40% and 50% (v/v)) by spectrophotometric method. The pKa's available in literature determined by various methods are compiled in comparison with the value of this work. These results are expected to essentially facilitate the research on occurrence, fate and effects, analysis method development, and control of antibiotics in various treatment occurrences.eninfo:eu-repo/semantics/closedAccessAcetonitrile-Water MixturesAcidity ConstantsMacrolidesSpectroscopic MethodArticle574980987N/AQ3