Nursal, Ayşe FeydaTürkmen, ErcanUzun Kaya, SüheylaTekcan, AkınSezer, ÖzlemÇelik, Sümeyya DenizYiğit, Serbülent2019-05-132019-05-132018Nursal, A. F., Turkmen, E., Kaya, S. U., Tekcan, A., Sezer, Ö., Çelik, S. D., Yiğit, S. (2018). Angiotensin converting enzyme gene insertion/deletion variant and familial Mediterranean fever-related amyloidosis. Iranian Journal of Kidney Diseases, 12(3), 150.1735-8582https://hdl.handle.net/11491/1711Introduction. The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis, which can lead to kidney failure. Genetic variability in the genes of various components of the renin-angiotensin system may play a role in the pathogenesis of the kidney disorders. The aim of the present study was to investigate the association between angiotensin converting enzyme (ACE) gene I/D variant and risk of developing FMF-related amyloidosis in Turkish patients. Materials and Methods. A total of 240 individuals consisting of 40 patients with FMF-related amyloidosis, 100 FMF patients without amyloidosis, and 100 healthy controls were recruited. For all of the participants, ACE I/D variant was detected by the polymerase chain reaction using specific primers. Results. A significant difference was found between the patients with FMF-related amyloidosis and the control group as for genotype distribution of ACE I/D variant (P < .05). The ACE D/D and I/D genotypes were more frequent in the patients with FMF-related amyloidosis while the I/I genotype was less frequent in the same patients. The FMF patients (with and without amyloidosis) had significantly higher percentages of the D/D and I/D genotypes than the healthy controls (P < .05). Comparison between the subgroups of FMF patients, divided into those with and without amyloidosis, yielded a significant correlation according to ID+II versus DD genotypes (P < .03, odds ratio, 3.24; 95% confidence interval, 1.05 to 12.01). Conclusions. Based on these observations, the ACE I/D variant D/D genotypes implicate a possible risk in the FMF-related amyloidosis among Turkish population. © 2018, Iranian Society of Nephrology. All rights reserved.eninfo:eu-repo/semantics/closedAccessAngiotensin-Converting EnzymeFamilial Mediterranean FeverSecondary AmyloidosisArticle123150155N/AQ3