Zaabal, MoufidaDoulache, MerzakKaradaş Bakırhan, NurgülKaddour, SamiaSaidat, BoubakeurÖzkan, Sibel Ayşıl2019-05-132019-05-132019Zaabal, M., Doulache, M., Bakirhan, N. K., Kaddour, S., Saidat, B., & Ozkan, S. A. (2019). A Facile Strategy for Construction of Sensor for Detection of Ondansetron and Investigation of its Redox Behavior and Thermodynamic Parameters. Electroanalysis, 31(7), 1279-1290.1040-0397https://doi.org/10.1002/elan.201800658https://hdl.handle.net/11491/1207A sodium dodecylsulfate-doped polypyrrole (SDS-PPy) film was elaborated on glassy carbon electrode (GCE) by an electrodeposition method in phosphate buffer solution (pH 2.0) containing pyrrole (Py) and sodium dodecyl sulfate (SDS). SDS-PPy/GCE was used for the construction of sensor, which showed excellent electrochemical response for the detection of ondansetron (OND) compared to conventional PPy. The application of the square wave (SW), with the adsorptive accumulation, indicates a maximum response at 1.33 V in H2SO4 (0.5 M). The influence of experimental parameters on determination of OND is discussed. The adsorptive stripping technique showed to be more sensitive, giving responses twice as big as those of non-accumulated OND. The substantial improvement of response permits the development of an electroanalytical technique with a linear concentration in the range (1.0–80 ?M), low detection (0.09 ?M), and quantification limits (0.3 ?M), and acceptable relative standard deviations of repeatability (0.59 %), and reproducibility (1.51 %). Consequently, this electrode is promising candidate for an accurate electroanalytical determination of OND in pharmaceutical samples with high sensitivity and selectivity, good accuracy and precision. The electrooxidation of OND at SDS-PPy/GCE at various temperatures were studied by cyclic voltammetry to evaluate both the kinetic (ks and Ea) and thermodynamic (?G*, ?H* and ?S*) parameters. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheimeninfo:eu-repo/semantics/closedAccessOndansetronPharmaceutical FormulationsSDS-PPy Film Modified ElectrodeSquare Wave Adsorptive Stripping VoltammetryThermodynamic StudyArticle10.1002/elan.201800658N/AQ2