Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin

Özkahraman, BengiEmeriewen, KrisztinaSaleh, George MichaelThanh, Nguy?n Thi Kim2020-02-132020-02-132020Ozkahraman, B., Emeriewen, K., Saleh, G. M., Thanh, N. T. K. (2020). Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin. RSC Advances, 10(7), 3926-3930.2046-2069https://doi.org/10.1039/c9ra06712dhttps://hdl.handle.net/11491/5735Herein, we focused on developing the feasibility of nano-enabled local anaesthetic (LA) delivery to anaesthetise the full thickness of eyelid skin. For this purpose a temperature-responsive hydrogel poly(Nvinylcaprolactam-co-hyaluronic acid) (p(VCL-co-HA)) was prepared through aqueous emulsion polymerization with a Food and Drug Administration (FDA) approved p(VCL) and hyaluronic acid (HA) showing remarkably high LA drug loading capacity.eninfo:eu-repo/semantics/openAccessEngineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skinArticle1073926393010.1039/c9ra06712dQ2WOS:0005099008000352-s2.0-85078705486Q1