Savcı, ÜnsalŞahin, MustafaŞenel, EnginÖztekin, AynureMuslu, ÜmranSungur, MustafaNeşelioğlu, SalimErel, Özcan2020-01-282020-01-282019Savci U, Sahin M, Senel E, Oztekin A, Muslu U, Sungur M, et al. (2019). Thiol/disulfide homeostasis in patients with telogen effluvium: Is oxidative stress important in the pathogenesis of telogen effluvium? Turk J Dermatol, 13(4) :131-4.1307-76351308-5255http://www.tjdonline.org/temp/TurkJDermatol134131-2529571_070135.pdfhttps://hdl.handle.net/11491/5657Objective: The aim of this study was to assess the correlation between telogen effluvium (TE) with the new oxidative stress (OS) indicator of thiol/disulfide balance and to research the role of OS in the pathogenesis of TE. Methods: Our study included 101 patients with TE diagnosis and 39 healthy individuals. Serum thiol/disulfide was measured with a new automated spectrometric method developed by Erel and Neselioglu, and results were compared statistically. Results: Among the six thiol/disulfide parameters, there were statistically significant differences for native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol studied in the patient and control groups (P = 0.042, 0.044, < 0.001, respectively). Conclusions: Based on the results of this study, it can be said that OS is closely associated with TE pathogenesis. There is a need for new studies that will show the possible effects of OS on TE pathogenesis and research different OS markers in addition to thiol/disulfide parameters.eninfo:eu-repo/semantics/openAccessAlopeciaDiffuse Hair LossDisulfideOxidative StressTelogen EffluviumThiolArticle13413113410.4103/TJD.TJD_26_19N/AQ4