Kavak, E.Algso, M. A. S.Konus, M.Yilmaz, C.Lazoglu, A.Karaagac, S. U.Kivrak, A.2021-11-012021-11-0120211070-42801608-3393https://doi.org/10.1134/S1070428021010139https://hdl.handle.net/11491/74642,3-Dialkynylthiophene derivatives were synthesized by using regio- and stereocontrolled Pd-catalyzed Sonogashira coupling and desilylation reactions. The synthesized compounds were analyzed in silico for their pharmacokinetic parameters, general toxicity, and drug scores. In particular, 3-ethynyl-2-(phenylethynyl)thiophene and 3-ethynyl-2-[(4-methylphenyl)ethynyl]thiophene were found to have relatively high drug scores and low toxicities. The antioxidant activity of the title compounds were evaluated by five different assays. 3-Ethynyl-2-(naphthalen-1-ylethynyl)thiophene displayed significant reducing and free radical scavenging activities.eninfo:eu-repo/semantics/closedAccessthiophenecoupling reactionsheteroaromatic compoundsADMEantioxidantsArticle571919910.1134/S1070428021010139Q4WOS:0006218232000132-s2.0-85101779491Q4