Tuna, Mazhar MüslümÇalışkan, MustafaÜnal, MustafaDemirci, TanerAyçiçek Doğan, BerçemKüçükler, Ferit KerimÖzbek, Mustafa NuriBerker, DilekDelibaşı, TuncayGüler, Serdar2019-05-132019-05-132016Tuna, M. M., Çalışkan, M., Ünal, M., Demirci, T., Ayçiçek Doğan, B., Küçükler, F. K., Özbek, M. N., Berker, D. [et.al.]. (2016). Normocalcemic hyperparathyroidism is associated with complications similar to those of hypercalcemic hyperparathyroidism. Journal of Bone and Mineral Metabolism, 34(3), 331-335.0914-8779https://doi.org/10.1007/s00774-015-0673-3https://hdl.handle.net/11491/1046Normocalcemic primary hyperparathyroidism (NC-PHPT) is a variant of hyperparathyroidism, characterized by normal serum calcium levels, high parathyroid hormone (PTH) and normal 25-OH vitamin D status. The present study aimed to compare complications related to hyperparathyroidism in patients with NC-PHPT and hypercalcemic PHPT (HC-PHPT). We retrospectively evaluated the records of 307 PHPT patients between January 2010 and March 2013. We excluded patients with impaired renal function and liver failure. All patients underwent a biochemical and hormonal examination including serum glucose, albumin, total calcium, phosphorus, creatinine, lipoproteins, PTH and 25-OH vitamin D. Nephrolithiasis and bone mineral density were documented based on a review of the medical records. The study population consisted of 36 (12 %) males and 271 (88 %) females with a mean age of 53.3 ± 9.5 years (29–70 years). Twenty-three of the patients were diagnosed with NC-PHPT (group 1) and 284 were diagnosed with HC-PHPT (group 2). There were no significant differences in terms of age, gender, prevalence of hypertension, low bone mineral density and kidney stones between the groups. The mean thyroid-stimulating hormone (TSH) and low-density lipoprotein (LDL) levels were significantly higher in group 1 than in group 2. Our study found that patients with NC-PHPT have similar several complications as patients with HC-PHPT. NC-PHPT patients have higher TSH levels despite being within the normal range, and higher LDL-C levels than patients with HC-PHPT. However, this relationship needs to be clarified in future studies with larger cohorts. © 2015, The Japanese Society for Bone and Mineral Research and Springer Japan.eninfo:eu-repo/semantics/closedAccessKidney StonesNormocalcemiaOsteoporosisParathormonePrimary HyperparathyroidismArticle34333133510.1007/s00774-015-0673-3N/AQ1