Ekinci, Adnan2019-05-102019-05-102018Ekinci, A. (2018). The effects of systemic steroid therapy on macrophage migration inhibitory factor concentrations in patients with nasal polyps. The Journal of Laryngology & Otology, 132(10), 891-895.0022-2151https://doi.org/10.1017/S0022215118001652https://hdl.handle.net/11491/563Objectives This study aimed to compare serum macrophage migration inhibitory factor concentrations before and after oral steroid therapy in nasal polyps patients, and determine whether there is a difference between pre-treatment macrophage migration inhibitory factor concentrations and healthy individuals.Methods The study included 24 patients with nasal polyps and 25 healthy individuals. The patient group received 1 mg/kg oral steroid.Results The mean macrophage migration inhibitory factor concentration before oral steroid therapy was 3889.79 pg/ml in the patient group and 2334.52 pg/ml in the control group. Macrophage migration inhibitory factor concentrations were statistically significantly higher in the pre-oral steroid therapy patient group than in the control group (p = 0.017). The mean pre- and post-oral steroid therapy serum macrophage migration inhibitory factor concentrations were 3889.79 pg/ml and 2451.25 pg/ml, respectively. The reduction in macrophage migration inhibitory factor concentrations was statistically significant (p = 0.010).Conclusion These findings suggest that concentrations of macrophage migration inhibitory factor may play a role in the pathogenesis of nasal polyps. Copyright © JLO (1984) Limited, 2018.eninfo:eu-repo/semantics/closedAccessMacrophage Migration-Inhibitory FactorsNasal PolypsSteroidsArticle1321089189510.1017/S0022215118001652N/AQ2