Arduç, AyşeAyçiçek Doğan, BerçemBilmez, Sevgiİmga Nasıroğlu, NarinTuna, Mazhar MüslümIşık, SerhatBerker, DilekGüler, Serdar2019-05-132019-05-132015Arduç, A., Ayçiçek Doğan, B., Bilmez, S., İmga Nasıroğlu, N., Tuna, M. M., Işık, S., Berker, D., Güler, S. (2015). High prevalence of Hashimoto’s thyroiditis in patients with polycystic ovary syndrome: does the imbalance between estradiol and progesterone play a role?. Endocrine Research, 40(4), 204-210.0743-5800https://doi.org/10.3109/07435800.2015.1015730https://hdl.handle.net/11491/1012Objective: Some similar factors, such as genetic susceptibility and subinflammation/autoimmunity, contribute to development of both polycystic ovary syndrome (PCOS) and Hashimoto’s thyroiditis (HT), suggesting a potential pathogenic link between the two common disorders. In this study, we investigated the relationship between PCOS and HT, considering the possible effect of PCOS-related hormonal and metabolic factors on thyroid autoimmunity. Methods: Eighty-six reproductive-age women diagnosed with PCOS according to Rotterdam criteria and 60 age-BMI matched control women were included in the study. All subjects had thyroid function tests, thyroid peroxidase anti-body (anti-TPO), thyroglobulin anti-body (anti-Tg), LH, FSH, estradiol, progesterone, androgens, fasting glucose, insulin, lipid, homeostasis model assessment insulin resistance (HOMA-IR) levels, thyroid and pelvic ultrasounds. Results: TSH, anti-TPO (p?=?0.017), anti-Tg (p?=?0.014), LH, DHEAS, testosterone, and HOMA-IR levels were significantly higher and progesterone were lower in PCOS women than in controls. Free T4, free T3, FSH, estradiol levels and thyroid volume were similar between the two groups. A higher percentage of PCOS patients had elevated TSH (26.7 and 5%; p?=?0.001), anti-TPO (26.7 and 6.6%; p?=?0.002), and anti-Tg (16.2 and 5%; p?=?0.039). HT was more common in PCOS patients compared to controls (22.1 and 5%; p?=?0.004). Estradiol (p?=?0.003) were higher in anti-TPO positive PCOS women than anti-TPO negative ones. Anti-TPO was correlated positively with estradiol, estradiol/progesterone ratio, and TSH. Conclusions: This study demonstrated a higher prevalence of HT, elevated TSH, anti-TPO, and anti-Tg levels in PCOS patients. Increased estrogen and estrogen/progesterone ratio seem to be directly involved in high anti-TPO levels in PCOS patients.eninfo:eu-repo/semantics/closedAccessEstradiolHashimoto’s ThyroiditisPolycystic Ovary SyndromeProgesteroneThyroid AutoantibodiesArticle40420421010.3109/07435800.2015.1015730N/AQ3