Başçeken, SinanBalcı, Mehmet2019-05-102019-05-102015Basceken, S., & Balci, M. (2015). Design of pyrazolo-pyrrolo-pyrazines and pyrazolo-pyrrolo-diazepines via AuCl3-catalyzed and NaH-supported cyclization of N-propargyl pyrazoles. The Journal of organic chemistry, 80(8), 3806-3814.0022-3263https://doi.org/10.1021/acs.joc.5b00034https://hdl.handle.net/11491/588A concise synthetic methodology for new heterocyclic scaffolds, such as pyrazolo-pyrrolo-pyrazine and pyrazolo-pyrrolo-diazepine skeletons, was developed. The key features of this method include (i) synthesis of pyrrole-derived ?,?-alkynyl ketones, (ii) introduction of various substituents into the alkyne functionality by Sonogashira cross-coupling, (iii) synthesis of pyrazole units by the reaction of ?,?-alkynyl compounds with hydrazine monohydrate, (iv) gold-catalyzed cyclization of pyrazoles with alkyne units, and (v) cyclization with NaH. Furthermore, this methodology allows various substituents to be introduced into all positions of the target compounds. © 2015 American Chemical Society.eninfo:eu-repo/semantics/closedAccess[Belirlenecek]Article8083806381410.1021/acs.joc.5b00034N/AQ2