Moran Bozer, BüşraÖzkahraman, BengiMert Balaban, Hümeyra2024-02-012024-02-012023Bozer, B. M., Özkahraman, B., & Mert, H. (2023). Photocrosslinked methacrylated pectin and methacrylated hyaluronic acıd wound dressing loaded with oleuropein as bioactive agent. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-13.0091-40371563-535Xhttps://doi.org/10.1080/00914037.2023.2235875https://hdl.handle.net/11491/8775Oleuropein-loaded photocrosslinked hydrogels, consisting of methacrylated pectin (PEC-MA) andmethacrylated hyaluronic acid (HA-MA), were developed as a new hydrogel wound dressing.Pectin and hyaluronic acid were methacrylated and the composite hydrogels were developed byphotocrosslinking of the methacrylated polymer precursors. Methacrylation and the photocros-slinking reactions were approved by1H-NMR and FTIR analyses. In addition to thermal and mor-phological characterizations, swelling andin vitrodegradation studies were performed. Moreimportantly, bioactivity studies, such as cytotoxicity, genotoxicity and hemolysis were performedto reveal the potential of the oleuropein-loaded photocrosslinked hybrid hydrogels for wounddressing applications.In vitroscratch assay studies showed that oleuropein-loaded wound dressingeffectively promoted the wound healing compared to the control in 24 hrs. Oleuropein-loadedphotocrosslinked hydrogels had no genotoxic and cytotoxic effects on L929 cells and could havea potential for wound healing applications.eninfo:eu-repo/semantics/closedAccessHydrogelWound DressingHyaluronic AcidPectinOleuropeinArticle10.1080/00914037.2023.2235875Q3WOS:001030186300001Q1