Pehlivan, SacideUysal, Mehmet AliAydın, Pelin C.Pehlivan, MustafaNursal, Ayşe FeydaYavuzlar, HazalKurnaz, SerdarSever, ÜlgenYavuz, Ferhat K.Uysal, SezerAydın, Nazan2019-05-102019-05-102017Pehlivan, S., Uysal, M.A., Aydin, P., Pehlivan, M., Nursal, A.F., Yavuzlar, H., Kurnaz, S., Sever, U., Yavuz, F., Uysal, S., & Aydin, N. (2017). eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia. Bratislavske lekarske listy, 118 (8), 467-471 .0006-9248https://doi.org/10.4149/BLL_2017_090https://hdl.handle.net/11491/486BACKGROUND: This study aimed to evaluate whether VNTR variants in the Endothelial Nitric Oxide Synthase (eNOS) and the XRCC4 gene play any role in nicotine dependence (ND) and/or Schizophrenia+ND (Sch+ND) ethiopathogenesis. METHODS: Present study included 100 individuals with ND, 60 patients with Sch+ND, and 70 healthy controls. These variants were analyzed using PCR. RESULTS: The cases with ND had higher eNOS VNTR-BB genotype than the healthy control subjects (p = 0.001). eNOS-AA genotype was lower in cases with Sch+ND and ND groups compared to the controls (p = 0.001, p = 0.001, respectively). eNOS-B allele was found significantly more frequently in Sch+ND group compared to the controls (p = 0.001). eNOS-A allele was significantly lower in ND group than the controls (p = 0.001). XRCC4-ID genotype was more common in the ND group than the control group (p = 0.001) as heterozygosity disadvantage. XRCC4-DD genotype was more common in the Sch+ND group compared to the controls (p = 0.035). The frequency of XRCC4-I allele was lower in the Sch+ND group compared to the controls (p = 0.012). CONCLUSIONS: Our results showed that eNOS and XRCC4 VNTR variants might play a potential role in Sch+ND and/or ND pathophysiology.eninfo:eu-repo/semantics/openAccessEndothelial Nitric Oxide SynthaseNicotine DependenceSchizophreniaXRCC4Article118846747110.4149/BLL_2017_090N/AQ2