Geyik, GülcanIşıklan, Nuran2021-11-012021-11-012021Geyik, G., & Işıklan, N. (2021). Design and fabrication of hybrid triple-responsive ?-carrageenan-based nanospheres for controlled drug delivery. International Journal of Biological Macromolecules, 192, 701-715.0141-8130https://doi.org/10.1016/j.ijbiomac.2021.10.007https://hdl.handle.net/11491/6170In the last two decades, the utilization of magnetic nanospheres in intelligent polymeric structures have received increased attention of researchers in numerous biomedical applications. Here, hybrid nanostructured triple-responsive magnetic nanospheres (?-Car-g-P(AA/DMA)@Fe3O4) containing inorganic iron oxide core (Fe3O4) and organic graft copolymeric shell based on ?-carrageenan (?-Car) and poly(acrylic acid/dimethylaminoethyl methacrylate) (P(AA/DMA)) were synthesized by microwave induced co-precipitation technique. The structure, size, surface morphology, magnetic property and stability of synthesized ?-Car-g-P(AA/DMA)@Fe3O4 magnetic nanospheres were characterized using FTIR, UV, XRD, TEM, Zeta-sizer, and VSM. ?-Car-g-P(AA/DMA)@Fe3O4 nanospheres were loaded with 5-Fluorouracil (5-FU) as an antineoplastic drug, and their 5-FU release behavior was explored in diverse graft yields, pH values, temperatures and in the existence of an alternating magnetic field. The ?-Car-g-P(AA/DMA)@Fe3O4 nanospheres demonstrated pH-, thermo-, and magnetic field-responsive 5-FU release with good biocompatibility and excellent anticancer activity. In addition, 5-FU release under 50 mT magnetic field reached to 100% within 4 h. This work exhibits that hybrid nanospheres have a triple stimuli-responsive influence, which is of principal importance for the future design and application of multi-functional responsive platforms to develop externally stimulated release of active agents and their healthcare capability.eninfo:eu-repo/semantics/closedAccessMagnetic Iron OxidePoly(acrylic acid)Poly(dimethylaminoethyl methacrylate)Stimuli-responsive Nanosystemκ-carrageenanArticle19270171510.1016/j.ijbiomac.2021.10.007Q1WOS:0007101846000102-s2.0-85117113370Q1