Arslan, Habibe S.Nursal, Ayse F.Inanir, AhmetKarakus, NevinYigit, Serbulent2021-11-012021-11-0120211871-53032212-3873https://doi.org/10.2174/1871530320666200910110915https://hdl.handle.net/11491/7488Background: Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain. It is more common in women than in men, and sex hormones may play a role in this predominance. Therefore, this research investigated the clinical findings among Turkish females and whether Estrogen-alpha (ESR1) gene variants are associated with FMS. Methods: A total of 219 individuals were enrolled in this study. ESR1 variants (Pvull/XbaI) were genotyped using PCR-RFLP methods. The results of the analyses were evaluated for statistical significance. Results: There was a significant association between the ESR1 PvuII and FMS risk among Turkish women. The ESR1 PvuII CC genotype and C allele were higher in the patients than those in the controls (p=0.021, p=0.007, respectively). A more statistically significant association was observed between the patients and the controls in terms of TT genotype vs. TC+CC genotypes (p=0.022). Also, there was a statistically significant association between the patients and the controls in terms of TT+TC genotype vs. CC genotypes (p =0.028). There was no significant association between patients and the control group concerning the genotype distribution and allele frequencies of ESR1 XbaI (p>0.05). Headache was seen more frequently in the XbaI GA genotype (p =0.025), while XbaI AA genotype was associated with dysmenorrhea in patients with FMS (p=0.041). Conclusion: Our results indicate that ESR1 PvuII/XbaI variants are possibly effective in the development of FMS and some clinical features.eninfo:eu-repo/semantics/closedAccessFibromiyalgia syndromeestrogen receptor-alphaPvullXbaIvariantwomenArticle2171326133210.2174/1871530320666200910110915Q4WOS:0006879724000032-s2.0-8511346497632914729Q2