Pehlivan, SacideUysal, Metin AtillaAydın, NazanNursal, Ayşe FeydaPehlivan, MustafaYavuzlar, HazalSever, ÜlgenKurnaz, SelinYavuz, Fatih KasımUysal, SunaÇetinay Aydın, Pınar2019-05-102019-05-102018Pehlivan, S., Uysal, M. A., Aydın, N., Nursal, A. F., Pehlivan, M., Yavuzlar, H., Sever, Ü., Yavuz, F. K., Uysal, S., Çetinay Aydın, P. (2018). XRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia. Archives of Clinical Psychiatry, 45(3), 53-56.0101-60831806-938Xhttps://doi.org/10.1590/0101-60830000000157https://hdl.handle.net/11491/690Background: Oxidative stress induced DNA damage has been assumed to contribute to the etiopathogenesis of schizophrenia (Sch). Smoking prevalence was more common in patients with Sch. The X-ray repair cross-complementation group 4 (XRCC4) gene plays an important role in the repair of DNA double-strand breaks. Objective: The purpose of this study was to investigate whether XRCC4 rs6869366 polymorphism has a relationship both in nicotine dependence (ND) and Sch+ND risk. Methods: One hundred and four patients with Sch+ND, 133 subjects with ND only and 70 healthy controls were enrolled in the study. XRCC4 rs6869366 polymorphism was analyzed using PCR-RFLP assay. Results: The frequency of XRCC4 rs6869366 GG genotype was more common in the ND and Sch+ND group than controls (p = 0.001 and p = 0.001, respectively). XRCC4 rs6869366 TT genotype was lower in both ND and Sch+ND group compared to controls (p = 0.001 and p = 0.001, respectively). Also, XRCC4 rs6869366 G allele was higher in Sch+ND group than controls (p = 0.001) while XRCC4 rs6869366 T allele was lower in ND group than healthy controls (p=0.001). XRCC4 rs6869366 GT genotype was lower in ND group than control group (p = 0.003). Discussion: These results suggested that the XRCC4 rs6869366 polymorphism G related genotype/allele was associated with susceptibility to both ND and Sch+ND in a Turkish population. © 2018, Universidade de Sao Paulo. All rights reserved.eninfo:eu-repo/semantics/openAccessDNA RepairNicotine DependenceSchizophreniaXRCC4Article453535610.1590/0101-60830000000157N/AQ4