Güner, AhmetKalçık, MacitGündüz, SabahattinÖzkan, Mehmet2019-05-132019-05-132019Güner, A., Kalçık, M., Gündüz, S., Özkan, M. (2019). Recently introduced thrombolytic therapy regimens have been sufficiently effective and safer in patients with prosthetic valve thrombosis. Journal of Cardiology Cases, 19(2), 74.1878-5409https://doi.org/10.1016/j.jccase.2018.11.002https://hdl.handle.net/11491/1768To the Editor, We have read with great interest the article by Araiza-Garaygordobil et al. entitled “Thrombolytic treatment for acute prosthetic valve thrombosis: Is it better than surgery?” [1]. The authors reported a case of mitral prosthetic valve thrombosis (PVT), which was successfully treated with an intravenous bolus of 15 mg tissue type plasminogen activator (t-PA) and continuous infusion of 85 mg t-PA for 90 min. We congratulate the authors for achieving a successful outcome in such a high-risk patient. However, we would like to contribute to the case report discussing the new low-dose slow-infusion thrombolytic therapy (TT) regimens which have been associated with lower complication rates.eninfo:eu-repo/semantics/openAccessOther1927410.1016/j.jccase.2018.11.0022-s2.0-85059830356Q4